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Database: UniProt
Entry: Q00393
LinkDB: Q00393
Original site: Q00393 
ID   FRHG_METVO              Reviewed;         243 AA.
AC   Q00393;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   05-DEC-2018, entry version 85.
DE   RecName: Full=Coenzyme F420 hydrogenase subunit gamma;
DE            EC=1.12.98.1;
DE   AltName: Full=8-hydroxy-5-deazaflavin-reducing hydrogenase subunit gamma;
DE            Short=FRH;
GN   Name=frhG; Synonyms=frcG;
OS   Methanococcus voltae.
OC   Archaea; Euryarchaeota; Methanomada group; Methanococci;
OC   Methanococcales; Methanococcaceae; Methanococcus.
OX   NCBI_TaxID=2188;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 33273 / DSM 1537 / NBRC 100457 / OCM 70 / PS;
RX   PubMed=1603063; DOI=10.1007/BF00587582;
RA   Halboth S., Klein A.;
RT   "Methanococcus voltae harbors four gene clusters potentially encoding
RT   two [NiFe] and two [NiFeSe] hydrogenases, each of the cofactor F420-
RT   reducing or F420-non-reducing types.";
RL   Mol. Gen. Genet. 233:217-224(1992).
CC   -!- FUNCTION: Reduces the physiological low-potential two-electron
CC       acceptor coenzyme F420, and the artificial one-electron acceptor
CC       methylviologen.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + H2 + oxidized coenzyme F420-(gamma-Glu)(n) =
CC         reduced coenzyme F420-(gamma-Glu)(n); Xref=Rhea:RHEA:23760,
CC         Rhea:RHEA-COMP:12939, Rhea:RHEA-COMP:14378, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:18276, ChEBI:CHEBI:133980, ChEBI:CHEBI:139511;
CC         EC=1.12.98.1;
CC   -!- COFACTOR:
CC       Name=Ni(2+); Xref=ChEBI:CHEBI:49786;
CC   -!- COFACTOR:
CC       Name=iron-sulfur cluster; Xref=ChEBI:CHEBI:30408;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC   -!- SUBUNIT: Complex of alpha, beta and gamma subunits.
CC   -!- SIMILARITY: Belongs to the FrhG family. {ECO:0000305}.
DR   EMBL; X61201; CAA43498.1; -; Genomic_DNA.
DR   PIR; S16723; S16723.
DR   ProteinModelPortal; Q00393; -.
DR   SMR; Q00393; -.
DR   PRIDE; Q00393; -.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0050454; F:coenzyme F420 hydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0016151; F:nickel cation binding; IEA:InterPro.
DR   Gene3D; 3.40.50.700; -; 1.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR017681; Coenz_F420_hydrogenase_gsu.
DR   InterPro; IPR006137; NADH_UbQ_OxRdtase-like_20kDa.
DR   InterPro; IPR037024; NiFe_Hase_small_N_sf.
DR   Pfam; PF00037; Fer4; 1.
DR   Pfam; PF01058; Oxidored_q6; 1.
DR   TIGRFAMs; TIGR03294; FrhG; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 1.
DR   PROSITE; PS51379; 4FE4S_FER_2; 2.
PE   3: Inferred from homology;
KW   4Fe-4S; Electron transport; Iron; Iron-sulfur; Metal-binding;
KW   Oxidoreductase; Repeat; Transport.
FT   CHAIN         1    243       Coenzyme F420 hydrogenase subunit gamma.
FT                                /FTId=PRO_0000159234.
FT   DOMAIN      182    210       4Fe-4S ferredoxin-type 1.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   DOMAIN      211    241       4Fe-4S ferredoxin-type 2.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00711}.
FT   METAL       191    191       Iron-sulfur 1 (4Fe-4S). {ECO:0000250}.
FT   METAL       194    194       Iron-sulfur 1 (4Fe-4S). {ECO:0000250}.
FT   METAL       197    197       Iron-sulfur 1 (4Fe-4S). {ECO:0000250}.
FT   METAL       201    201       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   METAL       220    220       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   METAL       223    223       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   METAL       226    226       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   METAL       230    230       Iron-sulfur 1 (4Fe-4S). {ECO:0000250}.
SQ   SEQUENCE   243 AA;  26040 MW;  8929559D9A0129AD CRC64;
     MVKIAHIHMS GCTGCLISLT DTYEKLLDIL GSVELVYALT LTGEKTEITE TDDKILIERD
     IPGGIDIALV EGSVCLDDHH SMDDILTTRK NSKKSLVALG ACAASGGVTR FRRVGQMSQP
     SHASFVPIGD VIKVDLALPG CPPSTESIVK LLTAALEGDM EYLEPFAEIA KYGKDACGCD
     VIKEVINKSL CMGCGTCAAA CQVNAIDMVE AKPNINSEFC IKCGICSAQC PRVRFPEIIR
     KLE
//
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