ID Q00WF6_OSTTA Unreviewed; 318 AA.
AC Q00WF6; A0A1Y5IC75; A0A454XL24;
DT 14-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 14-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 64.
DE RecName: Full=Probable magnesium transporter {ECO:0000256|RuleBase:RU363078};
GN ORFNames=BE221DRAFT_75977 {ECO:0000313|EMBL:OUS45824.1},
GN OT_ostta14g00470 {ECO:0000313|EMBL:CAL56802.1};
OS Ostreococcus tauri.
OC Eukaryota; Viridiplantae; Chlorophyta; Mamiellophyceae; Mamiellales;
OC Bathycoccaceae; Ostreococcus.
OX NCBI_TaxID=70448 {ECO:0000313|EMBL:CAL56802.1, ECO:0000313|Proteomes:UP000009170};
RN [1] {ECO:0000313|Proteomes:UP000009170}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=OTTH0595 {ECO:0000313|Proteomes:UP000009170};
RX PubMed=16868079; DOI=10.1073/pnas.0604795103;
RA Derelle E., Ferraz C., Rombauts S., Rouze P., Worden A.Z., Robbens S.,
RA Partensky F., Degroeve S., Echeynie S., Cooke R., Saeys Y., Wuyts J.,
RA Jabbari K., Bowler C., Panaud O., Piegu B., Ball S.G., Ral J.-P.,
RA Bouget F.-Y., Piganeau G., De Baets B., Picard A., Delseny M., Demaille J.,
RA Van de Peer Y., Moreau H.;
RT "Genome analysis of the smallest free-living eukaryote Ostreococcus tauri
RT unveils many unique features.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11647-11652(2006).
RN [2] {ECO:0000313|EMBL:CAL56802.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=RCC4221 {ECO:0000313|EMBL:CAL56802.1};
RA Derelle E., Ferraz C., Rombauts S., Rouze P., Worden A.Z., Robbens S.,
RA Partensky F., Degroeve S., Echeynie S., Cooke R., Saeys Y., Wuyts J.,
RA Jabbari K., Bowler C., Panaud O., Piegu B., Ball S., Ral J.P., Bouget F.Y.,
RA Piganeau G., De Baets B., Picard A., Delseny M., Demaille J.,
RA Van de Peer Y., Moreau H.;
RT "Genome analysis of the smallest free-living eukaryote Ostreococcus tauri
RT unveils many unique features.";
RL Proc. Natl. Acad. Sci. U.S.A. 131:11647-11652(2006).
RN [3] {ECO:0000313|EMBL:CAL56802.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=RCC4221 {ECO:0000313|EMBL:CAL56802.1};
RX PubMed=25494611; DOI=10.1186/1471-2164-15-1103;
RA Blanc-Mathieu R., Verhelst B., Derelle E., Rombauts S., Bouget F.Y.,
RA Carre I., Chateau A., Eyre-Walker A., Grimsley N., Moreau H., Piegu B.,
RA Rivals E., Schackwitz W., Van de Peer Y., Piganeau G.;
RT "An improved genome of the model marine alga Ostreococcus tauri unfolds by
RT assessing Illumina de novo assemblies.";
RL BMC Genomics 15:1103-1103(2014).
RN [4] {ECO:0000313|EMBL:OUS45824.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RCC 1115 {ECO:0000313|EMBL:OUS45824.1};
RG DOE Joint Genome Institute;
RA Blanc-Mathieu R., Krasovec M., Hebrard M., Yau S., Desgranges E.,
RA Martin J., Schackwitz W., Kuo A., Salin G., Donnadieu C., Desdevises Y.,
RA Sanchez-Ferandin S., Moreau H., Rivals E., Grigoriev I.V., Grimsley N.,
RA Eyre-Walker A., Piganeau G.;
RT "Population genomics of picophytoplankton unveils novel chromosome
RT hypervariability.";
RL Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as a Mg(2+) transporter. Can also transport other
CC divalent cations such as Fe(2+), Sr(2+), Ba(2+), Mn(2+) and Co(2+) but
CC to a much less extent than Mg(2+). {ECO:0000256|ARBA:ARBA00025284,
CC ECO:0000256|RuleBase:RU363078}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|RuleBase:RU363078}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU363078};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU363078}. Early
CC endosome {ECO:0000256|RuleBase:RU363078}. Endosome
CC {ECO:0000256|ARBA:ARBA00004177}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NIPA (TC 2.A.7) family.
CC {ECO:0000256|ARBA:ARBA00007001, ECO:0000256|RuleBase:RU363078}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU363078}.
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DR EMBL; CAID01000014; CAL56802.1; -; Genomic_DNA.
DR EMBL; KZ155785; OUS45824.1; -; Genomic_DNA.
DR RefSeq; XP_003082847.1; XM_003082799.1.
DR AlphaFoldDB; Q00WF6; -.
DR GeneID; 9837571; -.
DR KEGG; ota:OT_ostta14g00470; -.
DR InParanoid; Q00WF6; -.
DR OMA; WVRICKS; -.
DR OrthoDB; 926117at2759; -.
DR Proteomes; UP000009170; Chromosome 14.
DR Proteomes; UP000195557; Unassembled WGS sequence.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015095; F:magnesium ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.3730.20; -; 1.
DR InterPro; IPR008521; Mg_trans_NIPA.
DR PANTHER; PTHR12570:SF65; MAGNESIUM TRANSPORTER NIPA9-RELATED; 1.
DR PANTHER; PTHR12570; UNCHARACTERIZED; 1.
DR Pfam; PF05653; Mg_trans_NIPA; 1.
DR SUPFAM; SSF103481; Multidrug resistance efflux transporter EmrE; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|RuleBase:RU363078};
KW Endosome {ECO:0000256|RuleBase:RU363078};
KW Ion transport {ECO:0000256|RuleBase:RU363078};
KW Magnesium {ECO:0000256|RuleBase:RU363078};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363078};
KW Reference proteome {ECO:0000313|Proteomes:UP000009170};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363078};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363078}; Transport {ECO:0000256|RuleBase:RU363078}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..318
FT /note="Probable magnesium transporter"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5030174942"
FT TRANSMEM 72..92
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363078"
FT TRANSMEM 101..118
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363078"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363078"
FT TRANSMEM 195..216
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363078"
FT TRANSMEM 228..252
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363078"
FT TRANSMEM 258..279
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363078"
SQ SEQUENCE 318 AA; 33053 MW; C185B0E5470C2C7F CRC64;
MVLFAVALTV TSACAINVGK GMQKKAAKTL PRFGLTSVRT YVSDRAWRRG LELDILGGAG
MLLALSIAPM SVVQPASASG VAILAVVSHV YLGESLSMRE WRGVASCALG IVVLSRFAEG
GGDTAPLGGG RLFFAVILGI VFFLTPSVVL RRYSAGITAT DAKRYELIKV GAQCGMSFAL
SAACVKIGMR YLHNWLLLRA PVAFSVGAAL TALGLYFQTK GLRDGSSIVV VCVAGNVAQM
CVAAVYGLMI LGEPVPHTVF SLLGWITSWA FIMYGVIALG GSDSGAALAA ARDVRGQAVL
PVTAIGPGAH PRAKLNVH
//
