ID TOM70_CAEEL Reviewed; 569 AA.
AC Q02335;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 3.
DT 27-MAR-2024, entry version 152.
DE RecName: Full=Mitochondrial import receptor subunit tomm-70 {ECO:0000305};
DE AltName: Full=Translocase of outer mitochondrial membrane 70 {ECO:0000312|WormBase:ZK370.8};
GN Name=tomm-70 {ECO:0000312|WormBase:ZK370.8};
GN ORFNames=ZK370.8 {ECO:0000312|WormBase:ZK370.8};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=23727266; DOI=10.1016/j.jmb.2013.05.019;
RA Haslbeck V., Eckl J.M., Kaiser C.J., Papsdorf K., Hessling M., Richter K.;
RT "Chaperone-interacting TPR proteins in Caenorhabditis elegans.";
RL J. Mol. Biol. 425:2922-2939(2013).
CC -!- FUNCTION: Receptor that accelerates the import of all mitochondrial
CC precursor proteins. {ECO:0000250|UniProtKB:Q75Q39}.
CC -!- SUBUNIT: Forms part of the preprotein translocase complex of the outer
CC mitochondrial membrane (TOM complex). {ECO:0000250|UniProtKB:P07213}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC {ECO:0000269|PubMed:23727266}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:Q75Q39}.
CC -!- TISSUE SPECIFICITY: Expressed in body wall muscle cells, the pharynx
CC and structures in the tail. {ECO:0000269|PubMed:23727266}.
CC -!- SIMILARITY: Belongs to the Tom70 family. {ECO:0000305}.
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DR EMBL; BX284603; CCD61727.1; -; Genomic_DNA.
DR PIR; S44669; S44669.
DR RefSeq; NP_498932.3; NM_066531.4.
DR AlphaFoldDB; Q02335; -.
DR SMR; Q02335; -.
DR BioGRID; 41431; 8.
DR IntAct; Q02335; 1.
DR STRING; 6239.ZK370.8.1; -.
DR EPD; Q02335; -.
DR PaxDb; 6239-ZK370-8; -.
DR PeptideAtlas; Q02335; -.
DR EnsemblMetazoa; ZK370.8.1; ZK370.8.1; WBGene00022722.
DR GeneID; 176228; -.
DR KEGG; cel:CELE_ZK370.8; -.
DR UCSC; ZK370.8; c. elegans.
DR AGR; WB:WBGene00022722; -.
DR WormBase; ZK370.8; CE45970; WBGene00022722; tomm-70.
DR eggNOG; ENOG502SA77; Eukaryota.
DR HOGENOM; CLU_491954_0_0_1; -.
DR InParanoid; Q02335; -.
DR OrthoDB; 1083789at2759; -.
DR PhylomeDB; Q02335; -.
DR Reactome; R-CEL-5689880; Ub-specific processing proteases.
DR PRO; PR:Q02335; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00022722; Expressed in larva and 4 other cell types or tissues.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IDA:WormBase.
DR GO; GO:0030943; F:mitochondrion targeting sequence binding; IBA:GO_Central.
DR GO; GO:0002218; P:activation of innate immune response; ISS:UniProtKB.
DR GO; GO:0098586; P:cellular response to virus; ISS:UniProtKB.
DR GO; GO:0002230; P:positive regulation of defense response to virus by host; ISS:UniProtKB.
DR GO; GO:0032728; P:positive regulation of interferon-beta production; ISS:UniProtKB.
DR GO; GO:0030150; P:protein import into mitochondrial matrix; IBA:GO_Central.
DR GO; GO:0045039; P:protein insertion into mitochondrial inner membrane; IBA:GO_Central.
DR GO; GO:0042981; P:regulation of apoptotic process; ISS:UniProtKB.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR46208; MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70; 1.
DR PANTHER; PTHR46208:SF1; MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70; 1.
DR SMART; SM00028; TPR; 2.
DR SUPFAM; SSF48452; TPR-like; 1.
PE 2: Evidence at transcript level;
KW Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW Repeat; TPR repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..569
FT /note="Mitochondrial import receptor subunit tomm-70"
FT /id="PRO_0000106424"
FT TOPO_DOM 1..12
FT /note="Mitochondrial intermembrane"
FT /evidence="ECO:0000305"
FT TRANSMEM 13..32
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 33..569
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT REPEAT 44..77
FT /note="TPR 1"
FT /evidence="ECO:0000255"
FT REPEAT 119..152
FT /note="TPR 2"
FT /evidence="ECO:0000255"
FT REPEAT 221..254
FT /note="TPR 3"
FT /evidence="ECO:0000255"
FT REPEAT 510..544
FT /note="TPR 4"
FT /evidence="ECO:0000255"
SQ SEQUENCE 569 AA; 64867 MW; E077B97655DEE902 CRC64;
MVETTGISDQ TKKVLIGVAA AATVAGVGYL VYKSFGGSDL ERDLEEIKAL GNLKFKEKQY
DSALEAFTKG VEKAGPNSSD QIVAMLYQNR AACREKVGHS PFDILNDCMA ALKVDKKYTK
AYLRAAKALN DVGKKQDALA YLLAAFTLDS SLNKTNFEFF GKLLAIEPMS DCHIGKPLKI
EDVKPQPVAL FRIQQWCDTW DILDLFKTDL TRFEPEVLSE DQKQYQLALE KFKKGKYEEL
IDLLTEENSY PPAMILRGKM LSYSTDPNEA TRYIDKVGAK INELIGSEED EERKKLMRDA
FDILKIELMY TMADLDKFLE SVPKDDKERL FKLYSFASIF VVIRLNHFYS LKIWFQYNGC
VLDTAVTNHE QQMMADTNNA NRLLTEAEKN GTLTPHLSMI VTFLKLCTSE DYADVHRRIR
EMEELAESRS THFNLVLMSK VYMMTNNEES SKKLLEEAAR ITTRYLVPSR HLQTADLHVH
KPEAERLRLT TESANAAIAV DPFNFSAHVL HLLGTNGPEP MIKKENYERA MESIRNAALF
APPRELLMLK RMIPLMNAKK RAAEMLDMY
//
