ID   MUTL_PSEAB              Reviewed;         633 AA.
AC   Q02F72;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   14-NOV-2006, sequence version 1.
DT   27-MAR-2024, entry version 96.
DE   RecName: Full=DNA mismatch repair protein MutL {ECO:0000255|HAMAP-Rule:MF_00149};
GN   Name=mutL {ECO:0000255|HAMAP-Rule:MF_00149}; OrderedLocusNames=PA14_65350;
OS   Pseudomonas aeruginosa (strain UCBPP-PA14).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208963;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UCBPP-PA14;
RX   PubMed=17038190; DOI=10.1186/gb-2006-7-10-r90;
RA   Lee D.G., Urbach J.M., Wu G., Liberati N.T., Feinbaum R.L., Miyata S.,
RA   Diggins L.T., He J., Saucier M., Deziel E., Friedman L., Li L., Grills G.,
RA   Montgomery K., Kucherlapati R., Rahme L.G., Ausubel F.M.;
RT   "Genomic analysis reveals that Pseudomonas aeruginosa virulence is
RT   combinatorial.";
RL   Genome Biol. 7:R90.1-R90.14(2006).
CC   -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC       It is required for dam-dependent methyl-directed DNA mismatch repair.
CC       May act as a 'molecular matchmaker', a protein that promotes the
CC       formation of a stable complex between two or more DNA-binding proteins
CC       in an ATP-dependent manner without itself being part of a final
CC       effector complex. {ECO:0000255|HAMAP-Rule:MF_00149}.
CC   -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC       {ECO:0000255|HAMAP-Rule:MF_00149}.
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DR   EMBL; CP000438; ABJ14331.1; -; Genomic_DNA.
DR   RefSeq; WP_003095660.1; NZ_CP034244.1.
DR   AlphaFoldDB; Q02F72; -.
DR   SMR; Q02F72; -.
DR   KEGG; pau:PA14_65350; -.
DR   PseudoCAP; PA14_65350; -.
DR   HOGENOM; CLU_004131_4_2_6; -.
DR   BioCyc; PAER208963:G1G74-5521-MONOMER; -.
DR   Proteomes; UP000000653; Chromosome.
DR   GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR   GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR   GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR   CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR   CDD; cd03482; MutL_Trans_MutL; 1.
DR   Gene3D; 3.30.230.10; -; 1.
DR   Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR   Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR   Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR   HAMAP; MF_00149; DNA_mis_repair; 1.
DR   InterPro; IPR014762; DNA_mismatch_repair_CS.
DR   InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR   InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR   InterPro; IPR036890; HATPase_C_sf.
DR   InterPro; IPR002099; MutL/Mlh/PMS.
DR   InterPro; IPR038973; MutL/Mlh/Pms-like.
DR   InterPro; IPR014790; MutL_C.
DR   InterPro; IPR042120; MutL_C_dimsub.
DR   InterPro; IPR042121; MutL_C_regsub.
DR   InterPro; IPR037198; MutL_C_sf.
DR   InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR   InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR   NCBIfam; TIGR00585; mutl; 1.
DR   PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR   PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR   Pfam; PF01119; DNA_mis_repair; 1.
DR   Pfam; PF13589; HATPase_c_3; 1.
DR   Pfam; PF08676; MutL_C; 1.
DR   SMART; SM01340; DNA_mis_repair; 1.
DR   SMART; SM00853; MutL_C; 1.
DR   SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR   SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR   SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR   PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair.
FT   CHAIN           1..633
FT                   /note="DNA mismatch repair protein MutL"
FT                   /id="PRO_1000010058"
FT   REGION          337..364
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          383..405
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   633 AA;  69778 MW;  3F208AF687D674C6 CRC64;
     MSETPRIQLL SPRLANQIAA GEVVERPASV AKELLENSLD AGSRRIDVEV EQGGIKLLRV
     RDDGRGIPAD DLPLALARHA TSKIRELEDL ERVMSLGFRG EALASISSVA RLTMTSRTAD
     AGEAWQVETE GRDMQPRVQP AAHPVGTSVE VRDLFFNTPA RRKFLRAEKT EFDHLQEVIK
     RLALARFDVA FHLRHNGKTI FALHEARDEL ARARRVGAVC GQAFLEQALP IEVERNGLHL
     WGWVGLPTFS RSQPDLQYFY VNGRMVRDKL VAHAVRQAYR DVLYNGRHPT FVLFFEVDPA
     VVDVNVHPTK HEVRFRDSRM VHDFLYGTLH RALGEVRPDD QLAPPGATSL TEPRPTGAAA
     GEFGPQGEMR LAESVLESPA ARVGWSGGSS ASGGSSGYSA YTRPEAPPSL AEAGGAYKAY
     FAPLPAGEAP AALPESAQDI PPLGYALAQL KGIYILAENA HGLVLVDMHA AHERITYERL
     KVAMASEGLR GQPLLVPESI AVSEREADCA EEHSSWFQRL GFELQRLGPE SLAIRQIPAL
     LKQAEATQLV RDVIADLLEY GTSDRIQAHL NELLGTMACH GAVRANRRLT LPEMNALLRD
     MEITERSGQC NHGRPTWTQL GLDELDKLFL RGR
//