ID MUTS_LACLS Reviewed; 840 AA.
AC Q02VS3;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 14-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 93.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000255|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000255|HAMAP-Rule:MF_00096}; OrderedLocusNames=LACR_2519;
OS Lactococcus lactis subsp. cremoris (strain SK11).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Lactococcus; Lactococcus cremoris subsp. cremoris.
OX NCBI_TaxID=272622;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SK11;
RX PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA Makarova K.S., Slesarev A., Wolf Y.I., Sorokin A., Mirkin B., Koonin E.V.,
RA Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA Baldwin K., Lee J.-H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J.R., Hutkins R.,
RA O'Sullivan D., Steele J., Unlu G., Saier M.H. Jr., Klaenhammer T.,
RA Richardson P., Kozyavkin S., Weimer B.C., Mills D.A.;
RT "Comparative genomics of the lactic acid bacteria.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000255|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000255|HAMAP-Rule:MF_00096}.
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DR EMBL; CP000425; ABJ73949.1; -; Genomic_DNA.
DR RefSeq; WP_011677258.1; NC_008527.1.
DR AlphaFoldDB; Q02VS3; -.
DR SMR; Q02VS3; -.
DR KEGG; llc:LACR_2519; -.
DR HOGENOM; CLU_002472_4_0_9; -.
DR Proteomes; UP000000240; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; DNA damage; DNA repair; DNA-binding; Nucleotide-binding.
FT CHAIN 1..840
FT /note="DNA mismatch repair protein MutS"
FT /id="PRO_0000335173"
FT BINDING 601..608
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00096"
SQ SEQUENCE 840 AA; 94209 MW; 7595CDD348440A92 CRC64;
MAEKISPGMQ QYLDIKQDYP DAFLLFRMGD FYELFYEDAV NAAQILELTL TSRNKNSENP
IPMAGVPHHA ATEYIDKLVD LGYKVAVAEQ MEDPKKAVGI VKRAVTQVIT PGTTIDTANS
VDNNFLVAID FKAKRYALSY MDLSTGEFKV TELSEFSAVV GGIASLKARE IVVGFPLDEA
QVKVFERQMN LLISEQFEIP ENLLIELSGL TALENQAASK LLAYVKETQM RDLSHLQEVE
HYEIKDFLQL DFATKSSLEL TANKRENKKH GTLYWLLDET KTAMGTRMLR SWIDRPLVSN
SAIQKRMEIV QVFLDHFFER SDLIEALKGV YDLERLASRV SFGKAVPVDF LQLANSLSNV
PAIKNILEVL DETSLNELRS QLDEIPELSG LINSAISENA SRTITEGGII KKGYNVQLDK
YREALENGTS WIAKLEADEK AKTGISTLRI DYNRKDGYYF HITQSQLNSV PEHFYRKATL
KNSERFGSQE LTEIEEIMLE AREKSSSLEY DLFMGLRAET EQYIGRLQAL AKTIAEIDCL
QSLSVVAEKQ GYIRPTLTEG SRIVEIKGGR HAVVEAVMGA QEYVPNDIEL PEQTDIQLIT
GPNMSGKSTY MRQFALTVIM AQIGSFVPAK TANLPIFDAI FTRIGASDNL ISGESTFMVE
MSEANHAIQK ATSRSLIIFD ELGRGTATYD GMALAQAIIE YVHEYIGAKT LFATHYHELT
DLDKELDHLD NVHVATLEQN GNVTFLHKIT DGPADKSYGI HVAKIAGLPQ TLLERADLIL
QKLENKPLPA KKIADEQEQL SLFDFAENSS EIIEKIKGQN VDNMTAREAL NFLWELKDSL
//
