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Database: UniProt
Entry: Q03030
LinkDB: Q03030
Original site: Q03030 
ID   DCOA_SALTY              Reviewed;         591 AA.
AC   Q03030;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   10-APR-2019, entry version 122.
DE   RecName: Full=Oxaloacetate decarboxylase alpha chain;
DE            EC=7.2.4.2;
GN   Name=oadA1; Synonyms=oadA; OrderedLocusNames=STM0055;
GN   and
GN   Name=oadA2; OrderedLocusNames=STM3352;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=LT2;
RX   PubMed=1331067;
RA   Woehlke G., Wifling K., Dimroth P.;
RT   "Sequence of the sodium ion pump oxaloacetate decarboxylase from
RT   Salmonella typhimurium.";
RL   J. Biol. Chem. 267:22798-22803(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M.,
RA   Waterston R., Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium
RT   LT2.";
RL   Nature 413:852-856(2001).
CC   -!- FUNCTION: Catalyzes the decarboxylation of oxaloacetate coupled to
CC       Na(+) translocation.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + 2 Na(+)(in) + oxaloacetate = CO2 + 2 Na(+)(out) +
CC         pyruvate; Xref=Rhea:RHEA:57724, ChEBI:CHEBI:15361,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:16452, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:29101; EC=7.2.4.2;
CC   -!- COFACTOR:
CC       Name=biotin; Xref=ChEBI:CHEBI:57586;
CC   -!- SUBUNIT: Composed of three chains (alpha, beta, and gamma).
DR   EMBL; M96434; AAA02973.1; -; Unassigned_DNA.
DR   EMBL; AE006468; AAL19019.1; -; Genomic_DNA.
DR   EMBL; AE006468; AAL22221.1; -; Genomic_DNA.
DR   PIR; B44465; B44465.
DR   RefSeq; NP_459060.1; NC_003197.2.
DR   RefSeq; NP_462262.1; NC_003197.2.
DR   RefSeq; WP_000150421.1; NC_003197.2.
DR   ProteinModelPortal; Q03030; -.
DR   SMR; Q03030; -.
DR   TCDB; 3.B.1.1.1; the na(+)-transporting carboxylic acid decarboxylase (nat-dc) family.
DR   PaxDb; Q03030; -.
DR   PRIDE; Q03030; -.
DR   EnsemblBacteria; AAL19019; AAL19019; STM0055.
DR   EnsemblBacteria; AAL22221; AAL22221; STM3352.
DR   GeneID; 1251573; -.
DR   GeneID; 1254875; -.
DR   KEGG; stm:STM0055; -.
DR   KEGG; stm:STM3352; -.
DR   PATRIC; fig|99287.12.peg.3553; -.
DR   eggNOG; ENOG4107QSA; Bacteria.
DR   eggNOG; COG0511; LUCA.
DR   eggNOG; COG5016; LUCA.
DR   HOGENOM; HOG000231389; -.
DR   KO; K01571; -.
DR   OMA; ELHLHCH; -.
DR   PhylomeDB; Q03030; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0008948; F:oxaloacetate decarboxylase activity; IEA:InterPro.
DR   GO; GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR001882; Biotin_BS.
DR   InterPro; IPR000089; Biotin_lipoyl.
DR   InterPro; IPR003379; Carboxylase_cons_dom.
DR   InterPro; IPR005776; OadA.
DR   InterPro; IPR000891; PYR_CT.
DR   InterPro; IPR011053; Single_hybrid_motif.
DR   Pfam; PF00364; Biotin_lipoyl; 1.
DR   Pfam; PF00682; HMGL-like; 1.
DR   Pfam; PF02436; PYC_OADA; 1.
DR   SUPFAM; SSF51230; SSF51230; 1.
DR   TIGRFAMs; TIGR01108; oadA; 1.
DR   PROSITE; PS00188; BIOTIN; 1.
DR   PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR   PROSITE; PS50991; PYR_CT; 1.
PE   3: Inferred from homology;
KW   Biotin; Complete proteome; Ion transport; Reference proteome; Sodium;
KW   Sodium transport; Translocase; Transport.
FT   INIT_MET      1      1       Removed. {ECO:0000250}.
FT   CHAIN         2    591       Oxaloacetate decarboxylase alpha chain.
FT                                /FTId=PRO_0000146834.
FT   DOMAIN        3    263       Pyruvate carboxyltransferase.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01151}.
FT   DOMAIN      518    591       Biotinyl-binding. {ECO:0000255|PROSITE-
FT                                ProRule:PRU01066}.
FT   MOD_RES     557    557       N6-biotinyllysine. {ECO:0000250,
FT                                ECO:0000255|PROSITE-ProRule:PRU01066}.
SQ   SEQUENCE   591 AA;  63207 MW;  EE9CF9191E71D6BE CRC64;
     MTIAITDVVL RDAHQSLFAT RLRLDDMLPI AAALDDVGYG SLECWGGATF DACIRFLGED
     PWLRLRELKK AMPKTPLQML LRGQNLLGYR HYADDVVERF VERAVKNGMD VFRVFDAMND
     PRNMKAALQA VRSHGAHAQG TLSYTTSPAH TLQTWLDLTE QLLETGVDSI AIKDMSGILT
     PMAAYELVSE IKKRFEVRLH LHCHATTGMA EMALLKAIEA GVDGVDTAIS SMSATYGHPA
     TEALVATLAG TEHDTGLDIL KLENIAAYFR EVRKKYHAFE GQLKGYDSRI LVAQVPGGML
     TNLESQLKQQ NAADKLDQVL AEIPRVREDL GFIPLVTPTS QIVGTQAVLN VLTGERYKTI
     AKETAGILKG EYGHTPVPVN AALQARVLEG GAPVTCRPAD LLKPELAELE ADVRRQAQEK
     GITLAGNAID DVLTVALFPQ IGLKFLENRN NPAAFEPLPQ AEAAQPVAKA EKPAASGIYT
     VEVEGKAFVV KVSDGGDISQ LTAAVPAASS APVQAAAPAG AGTPVTAPLA GNIWKVIATE
     GQTVAEGDVL LILEAMKMET EIRAAQAGTV RGIAVKSGDA VSVGDTLMTL A
//
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