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Database: UniProt
Entry: Q03099
LinkDB: Q03099
Original site: Q03099 
ID   YMN3_YEAST              Reviewed;        1374 AA.
AC   Q03099; D6W0F2; Q12054;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   18-SEP-2019, entry version 133.
DE   RecName: Full=Y' element ATP-dependent helicase YML133C;
DE            EC=3.6.4.12;
GN   OrderedLocusNames=YML133C; ORFNames=YM4987.01C, YM4987.02C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
OC   Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169872;
RA   Bowman S., Churcher C.M., Badcock K., Brown D., Chillingworth T.,
RA   Connor R., Dedman K., Devlin K., Gentles S., Hamlin N., Hunt S.,
RA   Jagels K., Lye G., Moule S., Odell C., Pearson D., Rajandream M.A.,
RA   Rice P., Skelton J., Walsh S.V., Whitehead S., Barrell B.G.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome
RT   XIII.";
RL   Nature 387:90-93(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
RA   Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and
RT   now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=9837911; DOI=10.1074/jbc.273.50.33360;
RA   Yamada M., Hayatsu N., Matsuura A., Ishikawa F.;
RT   "Y'-Help1, a DNA helicase encoded by the yeast subtelomeric Y'
RT   element, is induced in survivors defective for telomerase.";
RL   J. Biol. Chem. 273:33360-33366(1998).
CC   -!- FUNCTION: Catalyzes DNA unwinding and is involved in telomerase-
CC       independent telomere maintenance. {ECO:0000269|PubMed:9837911}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC   -!- INDUCTION: Induced in absence of telomerase TLC1.
CC       {ECO:0000269|PubMed:9837911}.
CC   -!- SIMILARITY: Belongs to the helicase family. Yeast subtelomeric Y'
CC       repeat subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA90549.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC       Sequence=CAA90550.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
DR   EMBL; Z50178; CAA90549.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; Z50178; CAA90550.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BK006946; DAA09766.1; -; Genomic_DNA.
DR   PIR; S69875; S69875.
DR   RefSeq; NP_013573.1; NM_001182496.1.
DR   BioGrid; 35072; 24.
DR   DIP; DIP-7582N; -.
DR   STRING; 4932.YML133C; -.
DR   PaxDb; Q03099; -.
DR   PRIDE; Q03099; -.
DR   EnsemblFungi; YML133C_mRNA; YML133C; YML133C.
DR   GeneID; 854906; -.
DR   KEGG; sce:YML133C; -.
DR   EuPathDB; FungiDB:YML133C; -.
DR   SGD; S000004602; YML133C.
DR   OMA; TSATTTX; -.
DR   BioCyc; YEAST:G3O-32711-MONOMER; -.
DR   PRO; PR:Q03099; -.
DR   Proteomes; UP000002311; Chromosome XIII.
DR   GO; GO:0005739; C:mitochondrion; HDA:SGD.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0004386; F:helicase activity; ISS:SGD.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR021646; Sir1_ORC-binding.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF11603; Sir1; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Reference proteome; Repeat.
FT   CHAIN         1   1374       Y' element ATP-dependent helicase
FT                                YML133C.
FT                                /FTId=PRO_0000102209.
FT   DOMAIN      375    552       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      609    758       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     388    395       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
SQ   SEQUENCE   1374 AA;  155553 MW;  9867CAC68D2C497E CRC64;
     MKVSDRRKFE KANFDEFESA LNNKNDLVHC PSITLFESIP TEVRSFYEDE KSGLIKVVKF
     RTGAMDRKRS FEKIVVSVMV GKNVQKFLTF VEDEPDFQGG PIPSKYLIPK KINLMVYTLF
     QVHTLKFNRK DYDTLSLFYL NRGYYNELSF RVLERCHEIA SARPNDSSTM RTFTDFVSGA
     PIVRSLQKST IRRYGYNLAP HMFLLLHVDE LSIFSAYQAS LPGEKKVDTE RLKRDLCPRK
     PIEIKYFSQI CNDMMNKKDR LGDVLATAQR IRRRYNKNSS SEPRLKTLDG LTSERWIQWL
     GLESDYHCSF SSTRNAEDVV AGEAASSDHH QKISRVTRKR PREPKSTNDI LVAGQKLFGS
     SFEFRDLHQL RLCHEIYMAD TPSVAVQAPP GYGKTELFHL PLIALASKGD VKYVSFLFVP
     YTVLLANCMI RLSRCGCLNV APVRNFIEEG CDGVTDLYVG IYDDLASTNF TDRIAAWENI
     VECTFRTNNV KLGYLIVDEF HNFETEVYRQ SQFGGITNLD FDAFEKAIFL SGTAPEAVAD
     AALQRIGLTG LAKKSMDINE LKRSEDLSRG LSSYPTRMFN LIKEKSEVPL GHVHKIWKKV
     ESQPEEALKL LLALFEIEPE SKAIVVASTT NEVEELACSW RKYFRVVWIH GKLGAAEKVS
     RTKEFVTDGS MRVLIGTKLV TEGIDIKQLM MVIMLDNRLN IIELIQGVGR LRDGGLCYLL
     SRKNSWAARN RKGELPPIKE GCITEQVREF YGLESKKGKK GQHVGCCGSR TDLSADTVEL
     IERMDRLAEK QATASMSIVA LPSSFQESNS SDRCRKYCSS DEDSDTCIHG SANASTNATT
     NSSTNATTTA STNVRTSATT TASINVRTSA TTTESTNSST NATTTASTNV RTSATTTASI
     NVRTSATTTE STNSNTSATT TESTDSNTSA TTTESTDSNT SATTTASTNS STNATTTAST
     NSSTNATTTE STNASAKEDA NKDGNAEDNR FHPVTDINKE SYKRKGSQMV LLERKKLKAQ
     FPNTSENMNV LQFLGFRSDE IKHLFLYGID IYFCPEGVFT QYGLCKGCQK MFELCVCWAG
     QKVSYRRMAW EALAVERMLR NDEEYKEYLE DIEPYHGDPV GYLKFFSVKR GEIYSQIQRN
     YAWYLAITRR RETISVLDST RGKQGSQVFR MSGRQIKELY YKVWSNLRES KTEVLQYFLN
     WDEKKCREEW EAKDDTVFVE ALEKVGVFQR LRSMTSAGLQ GPQYVKLQFS RHHRQLRSRY
     ELSLGMHLRD QLALGVTPSK VPHWTAFLSM LIGLFYNKTF RQKLEYLLEQ ISEVWLLPHW
     VDLANVEVLA ADNTRVPLYM LMVAVHKELD SDDVPDGRFD IILLCRDSSR EVGE
//
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