ID YN81_CAEEL Reviewed; 1561 AA.
AC Q03610;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 22-SEP-2009, sequence version 6.
DT 27-MAR-2024, entry version 146.
DE RecName: Full=Uncharacterized protein ZC84.1;
DE Flags: Precursor;
GN ORFNames=ZC84.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
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DR EMBL; Z19157; CAA79569.3; -; Genomic_DNA.
DR PIR; E88550; E88550.
DR PIR; S28291; S28291.
DR RefSeq; NP_499036.3; NM_066635.3.
DR AlphaFoldDB; Q03610; -.
DR SMR; Q03610; -.
DR STRING; 6239.ZC84.1.1; -.
DR MEROPS; I02.955; -.
DR EPD; Q03610; -.
DR PaxDb; 6239-ZC84-1; -.
DR EnsemblMetazoa; ZC84.1.1; ZC84.1.1; WBGene00013846.
DR GeneID; 191073; -.
DR KEGG; cel:CELE_ZC84.1; -.
DR UCSC; ZC84.1; c. elegans.
DR AGR; WB:WBGene00013846; -.
DR WormBase; ZC84.1; CE43479; WBGene00013846; -.
DR eggNOG; KOG4295; Eukaryota.
DR HOGENOM; CLU_004071_0_0_1; -.
DR InParanoid; Q03610; -.
DR OMA; EKRCERS; -.
DR OrthoDB; 2872576at2759; -.
DR PhylomeDB; Q03610; -.
DR PRO; PR:Q03610; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00013846; Expressed in pharyngeal muscle cell (C elegans) and 2 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR CDD; cd00109; Kunitz-type; 3.
DR CDD; cd22593; Kunitz_conkunitzin; 1.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 5.
DR InterPro; IPR006150; Cys_repeat_1.
DR InterPro; IPR006149; EB_dom.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR028150; Lustrin_cystein.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR PANTHER; PTHR46339:SF3; PROTEIN CBG06944; 1.
DR PANTHER; PTHR46339; PROTEIN CBG15282-RELATED; 1.
DR Pfam; PF01683; EB; 3.
DR Pfam; PF00014; Kunitz_BPTI; 5.
DR Pfam; PF14625; Lustrin_cystein; 13.
DR PRINTS; PR00759; BASICPTASE.
DR SMART; SM00131; KU; 5.
DR SMART; SM00289; WR1; 16.
DR SUPFAM; SSF57362; BPTI-like; 5.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 3.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 5.
PE 3: Inferred from homology;
KW Disulfide bond; Protease inhibitor; Reference proteome; Repeat; Secreted;
KW Serine protease inhibitor; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..1561
FT /note="Uncharacterized protein ZC84.1"
FT /id="PRO_0000155462"
FT DOMAIN 309..363
FT /note="BPTI/Kunitz inhibitor 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT DOMAIN 365..412
FT /note="WR1 1"
FT DOMAIN 434..484
FT /note="BPTI/Kunitz inhibitor 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT DOMAIN 487..525
FT /note="WR1 2"
FT DOMAIN 531..581
FT /note="BPTI/Kunitz inhibitor 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT DOMAIN 588..629
FT /note="WR1 3"
FT DOMAIN 635..687
FT /note="BPTI/Kunitz inhibitor 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT DOMAIN 690..737
FT /note="WR1 4"
FT DOMAIN 743..795
FT /note="BPTI/Kunitz inhibitor 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT DOMAIN 798..845
FT /note="WR1 5"
FT DOMAIN 850..897
FT /note="WR1 6"
FT DOMAIN 902..950
FT /note="WR1 7"
FT DOMAIN 953..1000
FT /note="WR1 8"
FT DOMAIN 1012..1059
FT /note="WR1 9"
FT DOMAIN 1071..1115
FT /note="WR1 10"
FT DOMAIN 1118..1162
FT /note="WR1 11"
FT DOMAIN 1177..1209
FT /note="WR1 12"
FT DOMAIN 1223..1266
FT /note="WR1 13"
FT DOMAIN 1295..1342
FT /note="WR1 14"
FT DOMAIN 1376..1416
FT /note="WR1 15"
FT DOMAIN 1443..1488
FT /note="WR1 16"
FT DISULFID 309..363
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT DISULFID 333..359
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT DISULFID 459..480
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT DISULFID 531..581
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT DISULFID 540..564
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT DISULFID 556..577
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT DISULFID 635..687
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT DISULFID 645..670
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT DISULFID 662..683
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT DISULFID 743..795
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT DISULFID 753..778
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
FT DISULFID 770..791
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00031"
SQ SEQUENCE 1561 AA; 169365 MW; 40DAE9CA28D00AE7 CRC64;
MMFHSLGLLY LFLYVTLAED CIDRPCVECR HYIKQDDPCL HHGTKPMLFC DPQTNLIQES
STNFLECVQN RWVLRECVTG TIYESGRGCV DPTIQPFMQG FSVSGSGRVG DVCQYNTDCL
SGMYCATGLC SCLSTYILRE SYCYEKVNPN QPGCTYDVQC EAVWPGSKCR MDSSIGTCRC
PEETHVARET RDGWVCISLR DLSSGGTAPL YFVCALPEGA GFKISLNDPS PSMGAFPVGC
TVGSSATIEP VQGLHGGGAC MWPSDGEYIG DVYDCIHTSP HINLAEKFPQ SNYAPTADGV
CCPSRALACI QPQLTGPNPS EPRWWYNSVT GTCQQFMWDS GATEAKYHSP NNFKTIQHCE
SYCRDTCQRG SPQYSTESAV HSERPITSCA ASVSCANDFQ CTAIGSQHLC CPTPGSVCSA
KGGRPYDIQP RTSIHHPGFM VYTGKESIRF YYDPGTGRCQ DFVYKGAGGN YNNFLSKHEC
EMYCARLQCE RGSPLRIGEE AQRCQNNAQC PSSHECKADQ GVCCPRKQTI CAQPLRIGDC
TENVKRYWYN ARTRQCQMFE YTGCQGNDNN FDSIMDCQNF CKNAIPEPKC IQGQAYKDMF
GNFVTCSNGM GCPANYECYF DGSQWGCCPT KAFTCSLNTD SGIQCGAGST FKYYYNPQTQ
NCESFQYNGC DGNSNNFANR DACESYCSVG GCPNGGTPLR DHSGMVMVCG AQQTSCPDSH
ECIPVLVGNS LINRCCPTRA YMCGLPPQQG TQCGANYVQR YYFNIVTSQC TSFQFGGCDG
NANNFLNIQQ CRNFCMSNAC PAGNVAYVDP NSQMPINCNE ALSNSCPSGY ACTFNPLINN
HVCCGATDSG VCPEAEKAFI DTIDMSPREC LINIEQSCPA NYLCRFNMQK NKYYCCSSIT
GKTCPVGKFL YKDLRTSQPI RCTIGRNDQC PDGFTCQSYL ANAFQGFCCT ANSVCPDNAD
YLIDDQSQQP RACTQGTFVS CPNGYACRSL TSSADGFCCK SGTGALPPSV TDGCPPNEYV
YLVQGEIAQC DPFNPPNAPC PSEFTCQWSL SNQRYQCCGS NPAPTPQRPS DGCPNAQIAF
RDADAVRVCS AGAANCPAGY FCQFSSSNNQ FQCCGVSGGC PEESVAFVGM SGEPEKCVVG
QSNCPRGFAC QKSLAGHHVC CTVRKVACES NEVIIEGECH AQVGPGSECL ANEQCTGGSV
CEDAKCECRP PLKAVGGFCQ EEIQCSSNQV LHNGLCHNKA KLGEACLTVR QCQENSGCIE
GSCECKKGFI EKAGKCMTPV EKKSAVSSKS INNGVTCSKP GWNPLIDEEH ERPKHCSPIG
KACPNGYECQ INNRRTQYLC CAPDMSMSST VSIPSLPPPS TTTTERIMTT KKANLKVCPT
GRTPYLLNGA PQKCTISRCP AGYECTYRNN GYHCCSMANK PGLTVAGTTG SVVSKSTPSP
DQEKCPRGNP LIYPSTSSPV LCQPGKRGCP VGFGCVQSST SNNHICCPSR HSDRPGYQSE
SFGLGAYYSR GPPAAINPCE GYLVLVTRGV NGRIEKRCER SCPFPQIPIG GVCYELKNKA
T
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