ID Q03B28_LACP3 Unreviewed; 274 AA.
AC Q03B28;
DT 14-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 14-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 101.
DE SubName: Full=Aldo/keto reductase related enzyme {ECO:0000313|EMBL:ABJ69594.1};
GN OrderedLocusNames=LSEI_0758 {ECO:0000313|EMBL:ABJ69594.1};
OS Lacticaseibacillus paracasei (strain ATCC 334 / BCRC 17002 / CCUG 31169 /
OS CIP 107868 / KCTC 3260 / NRRL B-441) (Lactobacillus paracasei).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lacticaseibacillus.
OX NCBI_TaxID=321967 {ECO:0000313|EMBL:ABJ69594.1, ECO:0000313|Proteomes:UP000001651};
RN [1] {ECO:0000313|EMBL:ABJ69594.1, ECO:0000313|Proteomes:UP000001651}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 334 / BCRC 17002 / CCUG 31169 / CIP 107868 / KCTC 3260 /
RC NRRL B-441 {ECO:0000313|Proteomes:UP000001651};
RX PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA Makarova K., Slesarev A., Wolf Y., Sorokin A., Mirkin B., Koonin E.,
RA Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA Baldwin K., Lee J.H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J., Hutkins R.,
RA O'Sullivan D., Steele J., Unlu G., Saier M., Klaenhammer T., Richardson P.,
RA Kozyavkin S., Weimer B., Mills D.;
RT "Comparative genomics of the lactic acid bacteria.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
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DR EMBL; CP000423; ABJ69594.1; -; Genomic_DNA.
DR RefSeq; WP_011674268.1; NC_008526.1.
DR RefSeq; YP_806036.1; NC_008526.1.
DR AlphaFoldDB; Q03B28; -.
DR STRING; 321967.LSEI_0758; -.
DR PaxDb; 321967-LSEI_0758; -.
DR KEGG; lca:LSEI_0758; -.
DR PATRIC; fig|321967.11.peg.759; -.
DR HOGENOM; CLU_023205_0_1_9; -.
DR Proteomes; UP000001651; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR CDD; cd19132; AKR_AKR5D1_E1; 1.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 2.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001651}.
FT DOMAIN 14..256
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 47
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 105
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 72
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 274 AA; 30775 MW; 1E7AD33D19E4E95A CRC64;
MNYTLNDGNV LPAIGFGTYK LNGANGVRAM VGAVNVGYRM LDAAFNYENE GAVGEAVRQS
GIPRSQLTIA SKLPGRHHRY QEAIDTIEES LYRAGLDYYD LYLIHWPNPK EDLYVEAWQA
LIQAQRFGLV RSIGVSNSLP EHIDRLIKET DVTPAINQIE LHPYFNQQAQ REYDAAHNIQ
TVAWSPLGRG AVLQEPSIKK IAAAHGKNVG QVILRWDLQH QILPIPKSAH LARQRTNLDV
FDFTLTNEEM AAIDSLTKPD GRLKDQDPAV YQEF
//