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Database: UniProt
Entry: Q03Y12_LEUMM
LinkDB: Q03Y12_LEUMM
Original site: Q03Y12_LEUMM 
ID   Q03Y12_LEUMM            Unreviewed;       283 AA.
AC   Q03Y12;
DT   14-NOV-2006, integrated into UniProtKB/TrEMBL.
DT   14-NOV-2006, sequence version 1.
DT   31-JUL-2019, entry version 89.
DE   RecName: Full=2-dehydro-3-deoxyphosphooctonate aldolase {ECO:0000256|SAAS:SAAS00700405};
DE            EC=2.5.1.55 {ECO:0000256|SAAS:SAAS00700404};
GN   OrderedLocusNames=LEUM_0801 {ECO:0000313|EMBL:ABJ61910.1};
OS   Leuconostoc mesenteroides subsp. mesenteroides (strain ATCC 8293 /
OS   NCDO 523).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Leuconostocaceae;
OC   Leuconostoc.
OX   NCBI_TaxID=203120 {ECO:0000313|EMBL:ABJ61910.1, ECO:0000313|Proteomes:UP000000362};
RN   [1] {ECO:0000313|EMBL:ABJ61910.1, ECO:0000313|Proteomes:UP000000362}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8293 / NCDO 523 {ECO:0000313|Proteomes:UP000000362};
RX   PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA   Makarova K., Slesarev A., Wolf Y., Sorokin A., Mirkin B., Koonin E.,
RA   Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA   Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA   Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA   Baldwin K., Lee J.H., Diaz-Muniz I., Dosti B., Smeianov V.,
RA   Wechter W., Barabote R., Lorca G., Altermann E., Barrangou R.,
RA   Ganesan B., Xie Y., Rawsthorne H., Tamir D., Parker C., Breidt F.,
RA   Broadbent J., Hutkins R., O'Sullivan D., Steele J., Unlu G., Saier M.,
RA   Klaenhammer T., Richardson P., Kozyavkin S., Weimer B., Mills D.;
RT   "Comparative genomics of the lactic acid bacteria.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 3-
CC         deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate;
CC         Xref=Rhea:RHEA:14053, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:57693, ChEBI:CHEBI:58702, ChEBI:CHEBI:85985;
CC         EC=2.5.1.55; Evidence={ECO:0000256|SAAS:SAAS01123735};
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; lipopolysaccharide
CC       biosynthesis. {ECO:0000256|SAAS:SAAS00700395}.
CC   -!- PATHWAY: Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate
CC       biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-
CC       phosphate: step 2/3. {ECO:0000256|SAAS:SAAS00700401}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00700398}.
CC   -!- SIMILARITY: Belongs to the KdsA family.
CC       {ECO:0000256|SAAS:SAAS00700400}.
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DR   EMBL; CP000414; ABJ61910.1; -; Genomic_DNA.
DR   RefSeq; WP_011679578.1; NC_008531.1.
DR   STRING; 203120.LEUM_0801; -.
DR   EnsemblBacteria; ABJ61910; ABJ61910; LEUM_0801.
DR   GeneID; 29576288; -.
DR   KEGG; lme:LEUM_0801; -.
DR   eggNOG; ENOG4105CXR; Bacteria.
DR   eggNOG; COG2877; LUCA.
DR   HOGENOM; HOG000023021; -.
DR   KO; K01627; -.
DR   OMA; IKKPQFM; -.
DR   OrthoDB; 687380at2; -.
DR   BioCyc; LMES203120:GJ8T-795-MONOMER; -.
DR   UniPathway; UPA00030; -.
DR   UniPathway; UPA00357; UER00474.
DR   Proteomes; UP000000362; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008676; F:3-deoxy-8-phosphooctulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006269; KDO8P_synthase.
DR   PANTHER; PTHR21057; PTHR21057; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   TIGRFAMs; TIGR01362; KDO8P_synth; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000362};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00700397};
KW   Lipopolysaccharide biosynthesis {ECO:0000256|SAAS:SAAS00700406};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000362};
KW   Transferase {ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN       14    266       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   283 AA;  31491 MW;  90AEA9D661E54610 CRC64;
     MTKISEVFQE YNFSDDKLTL LAGPCAIESY ETCAEVAEKL KEITDELGIN FVFKSSFDKA
     NRSSLDSDRG AGMAHGLEIL KKIKETYNVP IVTDVHESYQ CEPVAKVADV LQIPAYLSRQ
     TDLLIAAGKT GRVVNIKKAQ FMAPEDIQSA VHKVEETNKH ILVTERGSMF GYHQLVVDMT
     SLIQMRETNF PIIYDATHSI QIPSGYGNHS GGNRDYAFPL MRAALTIGVA GIFAEVHPNP
     PKAISDQDSQ LYLSKIRPIL EVANDLFHQN LKMKAVYDHE GLL
//
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