GenomeNet

Database: UniProt
Entry: Q04688
LinkDB: Q04688
Original site: Q04688 
ID   ELG_DROME               Reviewed;         464 AA.
AC   Q04688; Q1LZ02; Q8SZC7; Q9VBA4;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   12-AUG-2020, entry version 176.
DE   RecName: Full=DNA-binding protein Ets97D;
DE            Short=D-elg;
GN   Name=Ets97D; Synonyms=elg; ORFNames=CG6338;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1461651;
RA   The S.M., Xie X., Smyth F., Papas T.S., Watson D.K., Schultz R.A.;
RT   "Molecular characterization and structural organization of D-elg, an ets
RT   proto-oncogene-related gene of Drosophila.";
RL   Oncogene 7:2471-2478(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley; TISSUE=Embryo;
RX   PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA   Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA   Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA   Celniker S.E.;
RT   "A Drosophila full-length cDNA resource.";
RL   Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Berkeley;
RA   Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA   Celniker S.E.;
RL   Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 298-449, FUNCTION, TISSUE SPECIFICITY, AND
RP   DEVELOPMENTAL STAGE.
RC   STRAIN=Canton-S; TISSUE=Larva;
RX   PubMed=1577186; DOI=10.1016/0012-1606(92)90225-6;
RA   Chen T., Bunting M., Karim F.D., Thummel C.S.;
RT   "Isolation and characterization of five Drosophila genes that encode an
RT   ets-related DNA binding domain.";
RL   Dev. Biol. 151:176-191(1992).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 323-463.
RC   STRAIN=Oregon-R; TISSUE=Pupae;
RX   PubMed=1713660;
RA   Pribyl L.J., Watson D.K., Schulz R.A., Papas T.S.;
RT   "D-elg, a member of the Drosophila ets gene family: sequence, expression
RT   and evolutionary comparison.";
RL   Oncogene 6:1175-1183(1991).
RN   [8]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-153; THR-157; SER-167 AND
RP   SER-171, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Embryo;
RX   PubMed=18327897; DOI=10.1021/pr700696a;
RA   Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT   "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL   J. Proteome Res. 7:1675-1682(2008).
CC   -!- FUNCTION: May have a role in germline development.
CC       {ECO:0000269|PubMed:1577186}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: Uniform distribution throughout embryonic
CC       development, with slightly higher expression in pole cells.
CC       {ECO:0000269|PubMed:1577186}.
CC   -!- DEVELOPMENTAL STAGE: Expressed throughout development with lower levels
CC       during larval development. {ECO:0000269|PubMed:1577186}.
CC   -!- SIMILARITY: Belongs to the ETS family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAL48582.1; Type=Frameshift; Evidence={ECO:0000305};
CC       Sequence=CAA41390.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
DR   EMBL; X68259; CAA48327.1; -; Genomic_DNA.
DR   EMBL; AE014297; AAF56638.1; -; Genomic_DNA.
DR   EMBL; AY070960; AAL48582.1; ALT_FRAME; mRNA.
DR   EMBL; BT025224; ABF17915.1; -; mRNA.
DR   EMBL; M88471; AAC34199.1; -; mRNA.
DR   EMBL; X58481; CAA41390.1; ALT_SEQ; mRNA.
DR   PIR; S24300; S24300.
DR   PIR; S37616; S37616.
DR   RefSeq; NP_524523.2; NM_079799.3.
DR   SMR; Q04688; -.
DR   BioGRID; 68127; 13.
DR   IntAct; Q04688; 2.
DR   STRING; 7227.FBpp0084458; -.
DR   iPTMnet; Q04688; -.
DR   PaxDb; Q04688; -.
DR   PRIDE; Q04688; -.
DR   EnsemblMetazoa; FBtr0085088; FBpp0084458; FBgn0004510.
DR   GeneID; 43236; -.
DR   KEGG; dme:Dmel_CG6338; -.
DR   CTD; 43236; -.
DR   FlyBase; FBgn0004510; Ets97D.
DR   eggNOG; KOG3806; Eukaryota.
DR   GeneTree; ENSGT00940000155799; -.
DR   HOGENOM; CLU_037064_1_0_1; -.
DR   InParanoid; Q04688; -.
DR   KO; K09441; -.
DR   OMA; QELEPHK; -.
DR   OrthoDB; 526256at2759; -.
DR   PhylomeDB; Q04688; -.
DR   Reactome; R-DME-2151201; Transcriptional activation of mitochondrial biogenesis.
DR   BioGRID-ORCS; 43236; 0 hits in 1 CRISPR screen.
DR   ChiTaRS; Ets97D; fly.
DR   GenomeRNAi; 43236; -.
DR   PRO; PR:Q04688; -.
DR   Proteomes; UP000000803; Chromosome 3R.
DR   Bgee; FBgn0004510; Expressed in female gonad and 25 other tissues.
DR   ExpressionAtlas; Q04688; baseline and differential.
DR   Genevisible; Q04688; DM.
DR   GO; GO:0042025; C:host cell nucleus; IEA:InterPro.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0009267; P:cellular response to starvation; IMP:FlyBase.
DR   GO; GO:1903862; P:positive regulation of oxidative phosphorylation; IMP:FlyBase.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:FlyBase.
DR   GO; GO:0000820; P:regulation of glutamine family amino acid metabolic process; IMP:FlyBase.
DR   GO; GO:0010821; P:regulation of mitochondrion organization; IMP:FlyBase.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   InterPro; IPR000418; Ets_dom.
DR   InterPro; IPR024668; GABP_asu_N.
DR   InterPro; IPR003118; Pointed_dom.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR016312; TF_GA-bd_asu.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00178; Ets; 1.
DR   Pfam; PF11620; GABP-alpha; 1.
DR   Pfam; PF02198; SAM_PNT; 1.
DR   PIRSF; PIRSF001703; GABP_alpha; 1.
DR   PRINTS; PR00454; ETSDOMAIN.
DR   SMART; SM00413; ETS; 1.
DR   SMART; SM00251; SAM_PNT; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR   PROSITE; PS00346; ETS_DOMAIN_2; 1.
DR   PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR   PROSITE; PS51433; PNT; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..464
FT                   /note="DNA-binding protein Ets97D"
FT                   /id="PRO_0000204094"
FT   DOMAIN          184..269
FT                   /note="PNT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00762"
FT   DNA_BIND        346..426
FT                   /note="ETS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00237"
FT   MOD_RES         153
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18327897"
FT   MOD_RES         157
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000269|PubMed:18327897"
FT   MOD_RES         167
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18327897"
FT   MOD_RES         171
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18327897"
FT   CONFLICT        454
FT                   /note="V -> L (in Ref. 1; CAA48327 and 5; CAA41390)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   464 AA;  52644 MW;  258A038E8DF427A2 CRC64;
     MNSSNDLSDE LIRRLSVGGA LEEVIASEMF EDSIDVETEA EPDDIIIVHM DIREPLSMLK
     SLVEQKIGVC LNYYTFWLQD AQELESHKNL VDQCVKGEGL VQINVQIQTI RKRINIADVL
     KPTEAALAAL AEEVVGQLSP PETASQKSSS SESPIKTPLK RMHKEDSEEE SVEGKDVKPV
     LNWVLDSKFK REQIRLKIPE AANEWTHAHV TYWLEWAVKQ FELVGINMSD WQMNGQELCA
     MTHEEFNQKL PRDPGNIFWT HLQLLKECNF VSVVHKRAEE QRKPKQPRIM SANSISTNSG
     GSLSLEQRIM RKSYQSVKSS DSVESTTSSM NPSNYTTIGS GNNGQVQLWQ FLLEILTDCE
     HTDVIEWVGT EGEFKLTDPD RVARLWGEKK NKPAMNYEKL SRALRYYYDG DMISKVSGKR
     FAYKFDCDLK LLIGYDANEL STLVSEGKTA PERVAATETI TEDT
//
DBGET integrated database retrieval system