ID BSH_DROME Reviewed; 429 AA.
AC Q04787; Q4V6V3; Q7KT32; Q9VIS2;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2006, sequence version 5.
DT 27-MAR-2024, entry version 188.
DE RecName: Full=Brain-specific homeobox protein;
GN Name=bsh; ORFNames=CG10604;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-429, FUNCTION, TISSUE SPECIFICITY,
RP AND DEVELOPMENTAL STAGE.
RC STRAIN=Oregon-R;
RX PubMed=8101170; DOI=10.1242/dev.117.2.793;
RA Jones B., McGinnis W.;
RT "A new Drosophila homeobox gene, bsh, is expressed in a subset of brain
RT cells during embryogenesis.";
RL Development 117:793-806(1993).
CC -!- FUNCTION: DNA binding protein that function as transcriptional
CC activator (By similarity). May play a role in the determination and
CC function of cell types in the brain. {ECO:0000250,
CC ECO:0000269|PubMed:8101170}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: Embryonic brain; accumulates in approximately 30
CC cells in each brain hemisphere. One of these cells is closely
CC associated with the terminus of the larval visual nerve (Bolwig's
CC nerve). {ECO:0000269|PubMed:8101170}.
CC -!- DEVELOPMENTAL STAGE: Expressed during embryogenesis with very low
CC levels found in the larva and adult. {ECO:0000269|PubMed:8101170}.
CC -!- SIMILARITY: Belongs to the distal-less homeobox family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB59219.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AE014134; AAF53843.3; -; Genomic_DNA.
DR EMBL; AE014134; AAS64721.2; -; Genomic_DNA.
DR EMBL; BT022203; AAY51597.1; -; mRNA.
DR EMBL; L06475; AAB59219.1; ALT_FRAME; Genomic_DNA.
DR RefSeq; NP_477350.2; NM_058002.3.
DR RefSeq; NP_995728.2; NM_206006.2.
DR AlphaFoldDB; Q04787; -.
DR SMR; Q04787; -.
DR BioGRID; 61242; 29.
DR DIP; DIP-17210N; -.
DR IntAct; Q04787; 7.
DR STRING; 7227.FBpp0088920; -.
DR PaxDb; 7227-FBpp0088920; -.
DR DNASU; 35266; -.
DR EnsemblMetazoa; FBtr0089320; FBpp0088920; FBgn0000529.
DR EnsemblMetazoa; FBtr0343855; FBpp0310398; FBgn0000529.
DR GeneID; 35266; -.
DR KEGG; dme:Dmel_CG10604; -.
DR AGR; FB:FBgn0000529; -.
DR CTD; 35266; -.
DR FlyBase; FBgn0000529; bsh.
DR VEuPathDB; VectorBase:FBgn0000529; -.
DR eggNOG; KOG0491; Eukaryota.
DR GeneTree; ENSGT00940000165097; -.
DR HOGENOM; CLU_049799_0_0_1; -.
DR InParanoid; Q04787; -.
DR OMA; CFLQHGY; -.
DR OrthoDB; 4204245at2759; -.
DR PhylomeDB; Q04787; -.
DR Reactome; R-DME-8853884; Transcriptional Regulation by VENTX.
DR SignaLink; Q04787; -.
DR BioGRID-ORCS; 35266; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 35266; -.
DR PRO; PR:Q04787; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0000529; Expressed in embryonic brain and 2 other cell types or tissues.
DR Genevisible; Q04787; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IMP:UniProtKB.
DR GO; GO:0048663; P:neuron fate commitment; IMP:FlyBase.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; NAS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR PANTHER; PTHR24333; HOMEO BOX HB9 LIKE A-RELATED; 1.
DR PANTHER; PTHR24333:SF12; HOMEOBOX PROTEIN CEH-62; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; DNA-binding; Homeobox; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..429
FT /note="Brain-specific homeobox protein"
FT /id="PRO_0000048841"
FT DNA_BIND 274..333
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 59..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 326..429
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 159..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..194
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 301
FT /note="T -> P (in Ref. 4; AAB59219)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 429 AA; 45714 MW; 32CF539EE0DEE572 CRC64;
MAMLNEASLS PADAHAHANA TTPTHSKAAA MASATTMLTT KTPFSIEHIL FQNLNSASNN
NNSSDTNGIA ANTNNYAPKS SRNAVKSARS AFAHDNNPHK HPSQHSHPPQ SHPPASASAS
ATATARSNQA ASGYAGEDYG KSMHSTPRSN HHSRHGTSHY NGDQISQQLG SGAAQHPPVP
TTQPQPPPPP PLNGGSGASN GVLYPNAPYT DHGFLQMTLG YLSPSSGTYK SVDPYFLSQA
SLFGGAPFFG APGCVPELAL GLGMGVNALR HCRRRKARTV FSDPQLSGLE KRFEGQRYLS
TPERVELATA LGLSETQVKT WFQNRRMKHK KQLRRRDNAN EPVDFSRSEP GKQPGEATSS
SGDSKHGKLN PGSVGGTPTQ PTSEQQLQMC LMQQGYSTDD YSDLEADSGD EDNSSDVDIV
GDAKLYQLT
//
