GenomeNet

Database: UniProt
Entry: Q04833
LinkDB: Q04833
Original site: Q04833 
ID   LRP_CAEEL               Reviewed;        4753 AA.
AC   Q04833;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   16-JAN-2019, entry version 152.
DE   RecName: Full=Low-density lipoprotein receptor-related protein;
DE            Short=LRP;
DE   Flags: Precursor;
GN   Name=lrp-1; ORFNames=F29D11.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8506301; DOI=10.1073/pnas.90.10.4572;
RA   Yochem J., Greenwald I.;
RT   "A gene for a low density lipoprotein receptor-related protein in the
RT   nematode Caenorhabditis elegans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 90:4572-4576(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
RN   [3]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-118, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RC   STRAIN=Bristol N2;
RX   PubMed=12754521; DOI=10.1038/nbt829;
RA   Kaji H., Saito H., Yamauchi Y., Shinkawa T., Taoka M., Hirabayashi J.,
RA   Kasai K., Takahashi N., Isobe T.;
RT   "Lectin affinity capture, isotope-coded tagging and mass spectrometry
RT   to identify N-linked glycoproteins.";
RL   Nat. Biotechnol. 21:667-672(2003).
RN   [4]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-1057; ASN-1597; ASN-1718
RP   AND ASN-4248, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=15888633; DOI=10.1093/glycob/cwi075;
RA   Fan X., She Y.-M., Bagshaw R.D., Callahan J.W., Schachter H.,
RA   Mahuran D.J.;
RT   "Identification of the hydrophobic glycoproteins of Caenorhabditis
RT   elegans.";
RL   Glycobiology 15:952-964(2005).
RN   [5]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-118; ASN-178; ASN-1431;
RP   ASN-1542; ASN-1545; ASN-1597; ASN-1718; ASN-2364; ASN-2762; ASN-3557;
RP   ASN-3752 AND ASN-4063, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=Bristol N2;
RX   PubMed=17761667; DOI=10.1074/mcp.M600392-MCP200;
RA   Kaji H., Kamiie J., Kawakami H., Kido K., Yamauchi Y., Shinkawa T.,
RA   Taoka M., Takahashi N., Isobe T.;
RT   "Proteomics reveals N-linked glycoprotein diversity in Caenorhabditis
RT   elegans and suggests an atypical translocation mechanism for integral
RT   membrane proteins.";
RL   Mol. Cell. Proteomics 6:2100-2109(2007).
CC   -!- FUNCTION: May act as a receptor for the endocytosis of
CC       extracellular ligands such as chylomicron remnants, protease-
CC       inhibitor complexes and vitellogenin.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein. Membrane, coated pit.
CC   -!- SIMILARITY: Belongs to the LDLR family. {ECO:0000305}.
DR   EMBL; M96150; AAA28105.1; -; Genomic_DNA.
DR   EMBL; Z73907; CAA98124.1; -; Genomic_DNA.
DR   PIR; A47437; A47437.
DR   RefSeq; NP_492127.1; NM_059726.5.
DR   UniGene; Cel.18450; -.
DR   ProteinModelPortal; Q04833; -.
DR   SMR; Q04833; -.
DR   BioGrid; 37962; 7.
DR   STRING; 6239.F29D11.1; -.
DR   iPTMnet; Q04833; -.
DR   EPD; Q04833; -.
DR   PaxDb; Q04833; -.
DR   PeptideAtlas; Q04833; -.
DR   PRIDE; Q04833; -.
DR   EnsemblMetazoa; F29D11.1; F29D11.1; WBGene00003071.
DR   GeneID; 172520; -.
DR   KEGG; cel:CELE_F29D11.1; -.
DR   UCSC; F29D11.1; c. elegans.
DR   CTD; 172520; -.
DR   WormBase; F29D11.1; CE05765; WBGene00003071; lrp-1.
DR   eggNOG; KOG1215; Eukaryota.
DR   eggNOG; ENOG410XP34; LUCA.
DR   GeneTree; ENSGT00940000166355; -.
DR   HOGENOM; HOG000230574; -.
DR   InParanoid; Q04833; -.
DR   KO; K06233; -.
DR   OMA; GNSIIWV; -.
DR   OrthoDB; 1606at2759; -.
DR   PhylomeDB; Q04833; -.
DR   Reactome; R-CEL-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   Reactome; R-CEL-8856828; Clathrin-mediated endocytosis.
DR   PRO; PR:Q04833; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00003071; Expressed in 5 organ(s), highest expression level in material anatomical entity.
DR   GO; GO:0016324; C:apical plasma membrane; IDA:WormBase.
DR   GO; GO:0005905; C:clathrin-coated pit; IEA:UniProtKB-SubCell.
DR   GO; GO:0030139; C:endocytic vesicle; IDA:WormBase.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0015248; F:sterol transporter activity; IMP:WormBase.
DR   GO; GO:0042395; P:ecdysis, collagen and cuticulin-based cuticle; IMP:WormBase.
DR   GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0002119; P:nematode larval development; IMP:WormBase.
DR   GO; GO:0040017; P:positive regulation of locomotion; IMP:WormBase.
DR   GO; GO:0040018; P:positive regulation of multicellular organism growth; IMP:WormBase.
DR   GO; GO:0030334; P:regulation of cell migration; IGI:WormBase.
DR   GO; GO:0015918; P:sterol transport; IMP:WormBase.
DR   CDD; cd00112; LDLa; 31.
DR   Gene3D; 2.120.10.30; -; 8.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR   InterPro; IPR013032; EGF-like_CS.
DR   InterPro; IPR000742; EGF-like_dom.
DR   InterPro; IPR018097; EGF_Ca-bd_CS.
DR   InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR000033; LDLR_classB_rpt.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   Pfam; PF00057; Ldl_recept_a; 29.
DR   Pfam; PF00058; Ldl_recept_b; 8.
DR   PRINTS; PR00261; LDLRECEPTOR.
DR   SMART; SM00181; EGF; 21.
DR   SMART; SM00179; EGF_CA; 8.
DR   SMART; SM00192; LDLa; 35.
DR   SMART; SM00135; LY; 32.
DR   SUPFAM; SSF57184; SSF57184; 2.
DR   SUPFAM; SSF57424; SSF57424; 33.
DR   PROSITE; PS00010; ASX_HYDROXYL; 6.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS01186; EGF_2; 3.
DR   PROSITE; PS50026; EGF_3; 2.
DR   PROSITE; PS01187; EGF_CA; 3.
DR   PROSITE; PS01209; LDLRA_1; 28.
DR   PROSITE; PS50068; LDLRA_2; 34.
DR   PROSITE; PS51120; LDLRB; 30.
PE   1: Evidence at protein level;
KW   Calcium; Coated pit; Complete proteome; Disulfide bond;
KW   EGF-like domain; Endocytosis; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Repeat; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL        1     18       {ECO:0000255}.
FT   CHAIN        19   4753       Low-density lipoprotein receptor-related
FT                                protein.
FT                                /FTId=PRO_0000017341.
FT   TOPO_DOM     19   4570       Extracellular. {ECO:0000255}.
FT   TRANSMEM   4571   4596       Helical. {ECO:0000255}.
FT   TOPO_DOM   4597   4753       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN       51     89       LDL-receptor class A 1.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN       90    133       LDL-receptor class A 2.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN      136    177       LDL-receptor class A 3.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN      180    220       LDL-receptor class A 4.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN      221    259       LDL-receptor class A 5.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN      260    298       LDL-receptor class A 6.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN      299    337       EGF-like 1. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN      338    368       EGF-like 2; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   REPEAT      436    482       LDL-receptor class B 1.
FT   REPEAT      483    525       LDL-receptor class B 2.
FT   REPEAT      526    566       LDL-receptor class B 3.
FT   REPEAT      567    609       LDL-receptor class B 4.
FT   REPEAT      610    654       LDL-receptor class B 5.
FT   DOMAIN      669    712       EGF-like 3. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   REPEAT      766    808       LDL-receptor class B 6.
FT   REPEAT      809    858       LDL-receptor class B 7.
FT   REPEAT      859    902       LDL-receptor class B 8.
FT   REPEAT      903    944       LDL-receptor class B 9.
FT   DOMAIN      997   1043       EGF-like 4. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     1052   1097       LDL-receptor class A 7.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1099   1140       LDL-receptor class A 8.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1144   1184       LDL-receptor class A 9.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1185   1225       LDL-receptor class A 10.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1226   1265       LDL-receptor class A 11.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1268   1309       LDL-receptor class A 12.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1311   1352       LDL-receptor class A 13.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1357   1397       LDL-receptor class A 14.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     1398   1436       EGF-like 5. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     1437   1476       EGF-like 6. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   REPEAT     1524   1566       LDL-receptor class B 10.
FT   REPEAT     1567   1610       LDL-receptor class B 11.
FT   REPEAT     1611   1654       LDL-receptor class B 12.
FT   REPEAT     1655   1699       LDL-receptor class B 13.
FT   DOMAIN     1747   1786       EGF-like 7. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   REPEAT     1894   1942       LDL-receptor class B 14.
FT   REPEAT     1943   1989       LDL-receptor class B 15.
FT   REPEAT     1990   2032       LDL-receptor class B 16.
FT   DOMAIN     2080   2120       EGF-like 8. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   REPEAT     2215   2259       LDL-receptor class B 17.
FT   REPEAT     2260   2303       LDL-receptor class B 18.
FT   REPEAT     2304   2345       LDL-receptor class B 19.
FT   DOMAIN     2396   2439       EGF-like 9. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   REPEAT     2582   2632       LDL-receptor class B 20.
FT   REPEAT     2633   2675       LDL-receptor class B 21.
FT   DOMAIN     2728   2780       EGF-like 10. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     2790   2831       LDL-receptor class A 15.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2832   2870       LDL-receptor class A 16.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2872   2914       LDL-receptor class A 17.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2917   2958       LDL-receptor class A 18.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     2959   2999       LDL-receptor class A 19.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3004   3046       LDL-receptor class A 20.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3047   3095       LDL-receptor class A 21.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3098   3137       LDL-receptor class A 22.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3138   3176       LDL-receptor class A 23.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3185   3223       LDL-receptor class A 24.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3224   3265       EGF-like 11. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     3266   3306       EGF-like 12; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   REPEAT     3354   3401       LDL-receptor class B 22.
FT   REPEAT     3402   3444       LDL-receptor class B 23.
FT   REPEAT     3445   3493       LDL-receptor class B 24.
FT   REPEAT     3494   3536       LDL-receptor class B 25.
FT   REPEAT     3537   3577       LDL-receptor class B 26.
FT   DOMAIN     3582   3624       EGF-like 13. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     3625   3668       LDL-receptor class A 25.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3669   3707       LDL-receptor class A 26.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3707   3748       LDL-receptor class A 27.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3751   3790       LDL-receptor class A 28.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3791   3832       LDL-receptor class A 29.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3831   3873       LDL-receptor class A 30.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3876   3914       LDL-receptor class A 31.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3915   3953       LDL-receptor class A 32.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3957   3997       LDL-receptor class A 33.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     3998   4042       LDL-receptor class A 34.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     4047   4085       LDL-receptor class A 35.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00124}.
FT   DOMAIN     4088   4131       EGF-like 14. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     4132   4176       EGF-like 15; calcium-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00076}.
FT   REPEAT     4227   4276       LDL-receptor class B 27.
FT   REPEAT     4343   4386       LDL-receptor class B 28.
FT   REPEAT     4388   4429       LDL-receptor class B 29.
FT   REPEAT     4430   4470       LDL-receptor class B 30.
FT   DOMAIN     4477   4515       EGF-like 16. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   DOMAIN     4526   4554       EGF-like 17. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00076}.
FT   MOTIF      4653   4658       Endocytosis signal. {ECO:0000255}.
FT   SITE       4744   4744       Critical for endocytosis. {ECO:0000250}.
FT   CARBOHYD     17     17       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    118    118       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:12754521,
FT                                ECO:0000269|PubMed:17761667}.
FT   CARBOHYD    178    178       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:17761667}.
FT   CARBOHYD    380    380       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    887    887       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1039   1039       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1057   1057       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:15888633}.
FT   CARBOHYD   1184   1184       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   1431   1431       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:17761667}.
FT   CARBOHYD   1542   1542       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:17761667}.
FT   CARBOHYD   1545   1545       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:17761667}.
FT   CARBOHYD   1597   1597       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:15888633,
FT                                ECO:0000269|PubMed:17761667}.
FT   CARBOHYD   1718   1718       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:15888633,
FT                                ECO:0000269|PubMed:17761667}.
FT   CARBOHYD   1871   1871       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2364   2364       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:17761667}.
FT   CARBOHYD   2501   2501       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2762   2762       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:17761667}.
FT   CARBOHYD   2888   2888       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   2996   2996       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3046   3046       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3134   3134       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3557   3557       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:17761667}.
FT   CARBOHYD   3626   3626       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3682   3682       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   3752   3752       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:17761667}.
FT   CARBOHYD   4063   4063       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:17761667}.
FT   CARBOHYD   4139   4139       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD   4248   4248       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000269|PubMed:15888633}.
FT   DISULFID     53     65       {ECO:0000250}.
FT   DISULFID     60     78       {ECO:0000250}.
FT   DISULFID     72     87       {ECO:0000250}.
FT   DISULFID     92    109       {ECO:0000250}.
FT   DISULFID     99    122       {ECO:0000250}.
FT   DISULFID    116    131       {ECO:0000250}.
FT   DISULFID    138    152       {ECO:0000250}.
FT   DISULFID    146    165       {ECO:0000250}.
FT   DISULFID    159    175       {ECO:0000250}.
FT   DISULFID    182    195       {ECO:0000250}.
FT   DISULFID    189    208       {ECO:0000250}.
FT   DISULFID    202    218       {ECO:0000250}.
FT   DISULFID    223    235       {ECO:0000250}.
FT   DISULFID    230    248       {ECO:0000250}.
FT   DISULFID    242    257       {ECO:0000250}.
FT   DISULFID    262    275       {ECO:0000250}.
FT   DISULFID    269    288       {ECO:0000250}.
FT   DISULFID    282    297       {ECO:0000250}.
FT   DISULFID    302    311       {ECO:0000250}.
FT   DISULFID    307    320       {ECO:0000250}.
FT   DISULFID    322    336       {ECO:0000250}.
FT   DISULFID    342    352       {ECO:0000250}.
FT   DISULFID    348    361       {ECO:0000250}.
FT   DISULFID    363    367       {ECO:0000250}.
FT   DISULFID    673    682       {ECO:0000250}.
FT   DISULFID    678    697       {ECO:0000250}.
FT   DISULFID    699    711       {ECO:0000250}.
FT   DISULFID   1001   1010       {ECO:0000250}.
FT   DISULFID   1006   1026       {ECO:0000250}.
FT   DISULFID   1028   1042       {ECO:0000250}.
FT   DISULFID   1054   1068       {ECO:0000250}.
FT   DISULFID   1063   1081       {ECO:0000250}.
FT   DISULFID   1075   1095       {ECO:0000250}.
FT   DISULFID   1101   1114       {ECO:0000250}.
FT   DISULFID   1108   1127       {ECO:0000250}.
FT   DISULFID   1121   1138       {ECO:0000250}.
FT   DISULFID   1146   1158       {ECO:0000250}.
FT   DISULFID   1153   1171       {ECO:0000250}.
FT   DISULFID   1165   1182       {ECO:0000250}.
FT   DISULFID   1187   1199       {ECO:0000250}.
FT   DISULFID   1194   1212       {ECO:0000250}.
FT   DISULFID   1206   1223       {ECO:0000250}.
FT   DISULFID   1228   1241       {ECO:0000250}.
FT   DISULFID   1235   1254       {ECO:0000250}.
FT   DISULFID   1248   1263       {ECO:0000250}.
FT   DISULFID   1270   1283       {ECO:0000250}.
FT   DISULFID   1277   1296       {ECO:0000250}.
FT   DISULFID   1290   1307       {ECO:0000250}.
FT   DISULFID   1313   1325       {ECO:0000250}.
FT   DISULFID   1320   1338       {ECO:0000250}.
FT   DISULFID   1332   1350       {ECO:0000250}.
FT   DISULFID   1359   1373       {ECO:0000250}.
FT   DISULFID   1366   1386       {ECO:0000250}.
FT   DISULFID   1380   1396       {ECO:0000250}.
FT   DISULFID   1401   1412       {ECO:0000250}.
FT   DISULFID   1408   1421       {ECO:0000250}.
FT   DISULFID   1423   1435       {ECO:0000250}.
FT   DISULFID   1441   1451       {ECO:0000250}.
FT   DISULFID   1447   1460       {ECO:0000250}.
FT   DISULFID   1462   1475       {ECO:0000250}.
FT   DISULFID   1751   1760       {ECO:0000250}.
FT   DISULFID   1756   1770       {ECO:0000250}.
FT   DISULFID   1772   1785       {ECO:0000250}.
FT   DISULFID   2084   2095       {ECO:0000250}.
FT   DISULFID   2091   2105       {ECO:0000250}.
FT   DISULFID   2107   2119       {ECO:0000250}.
FT   DISULFID   2400   2415       {ECO:0000250}.
FT   DISULFID   2411   2426       {ECO:0000250}.
FT   DISULFID   2428   2438       {ECO:0000250}.
FT   DISULFID   2732   2743       {ECO:0000250}.
FT   DISULFID   2739   2759       {ECO:0000250}.
FT   DISULFID   2761   2779       {ECO:0000250}.
FT   DISULFID   2792   2805       {ECO:0000250}.
FT   DISULFID   2800   2818       {ECO:0000250}.
FT   DISULFID   2812   2829       {ECO:0000250}.
FT   DISULFID   2834   2846       {ECO:0000250}.
FT   DISULFID   2841   2859       {ECO:0000250}.
FT   DISULFID   2853   2868       {ECO:0000250}.
FT   DISULFID   2874   2886       {ECO:0000250}.
FT   DISULFID   2881   2899       {ECO:0000250}.
FT   DISULFID   2893   2912       {ECO:0000250}.
FT   DISULFID   2919   2932       {ECO:0000250}.
FT   DISULFID   2926   2945       {ECO:0000250}.
FT   DISULFID   2939   2956       {ECO:0000250}.
FT   DISULFID   2961   2973       {ECO:0000250}.
FT   DISULFID   2968   2986       {ECO:0000250}.
FT   DISULFID   2980   2997       {ECO:0000250}.
FT   DISULFID   3006   3019       {ECO:0000250}.
FT   DISULFID   3014   3032       {ECO:0000250}.
FT   DISULFID   3026   3044       {ECO:0000250}.
FT   DISULFID   3049   3069       {ECO:0000250}.
FT   DISULFID   3056   3082       {ECO:0000250}.
FT   DISULFID   3076   3093       {ECO:0000250}.
FT   DISULFID   3100   3112       {ECO:0000250}.
FT   DISULFID   3107   3125       {ECO:0000250}.
FT   DISULFID   3119   3135       {ECO:0000250}.
FT   DISULFID   3140   3152       {ECO:0000250}.
FT   DISULFID   3147   3165       {ECO:0000250}.
FT   DISULFID   3159   3174       {ECO:0000250}.
FT   DISULFID   3187   3199       {ECO:0000250}.
FT   DISULFID   3194   3212       {ECO:0000250}.
FT   DISULFID   3206   3222       {ECO:0000250}.
FT   DISULFID   3227   3239       {ECO:0000250}.
FT   DISULFID   3235   3248       {ECO:0000250}.
FT   DISULFID   3250   3264       {ECO:0000250}.
FT   DISULFID   3270   3281       {ECO:0000250}.
FT   DISULFID   3277   3290       {ECO:0000250}.
FT   DISULFID   3292   3305       {ECO:0000250}.
FT   DISULFID   3586   3597       {ECO:0000250}.
FT   DISULFID   3593   3608       {ECO:0000250}.
FT   DISULFID   3610   3623       {ECO:0000250}.
FT   DISULFID   3627   3641       {ECO:0000250}.
FT   DISULFID   3634   3654       {ECO:0000250}.
FT   DISULFID   3648   3666       {ECO:0000250}.
FT   DISULFID   3671   3683       {ECO:0000250}.
FT   DISULFID   3678   3696       {ECO:0000250}.
FT   DISULFID   3690   3705       {ECO:0000250}.
FT   DISULFID   3709   3722       {ECO:0000250}.
FT   DISULFID   3716   3735       {ECO:0000250}.
FT   DISULFID   3729   3746       {ECO:0000250}.
FT   DISULFID   3753   3765       {ECO:0000250}.
FT   DISULFID   3760   3778       {ECO:0000250}.
FT   DISULFID   3772   3788       {ECO:0000250}.
FT   DISULFID   3793   3806       {ECO:0000250}.
FT   DISULFID   3800   3819       {ECO:0000250}.
FT   DISULFID   3813   3830       {ECO:0000250}.
FT   DISULFID   3833   3847       {ECO:0000250}.
FT   DISULFID   3841   3860       {ECO:0000250}.
FT   DISULFID   3854   3871       {ECO:0000250}.
FT   DISULFID   3878   3890       {ECO:0000250}.
FT   DISULFID   3885   3903       {ECO:0000250}.
FT   DISULFID   3897   3912       {ECO:0000250}.
FT   DISULFID   3917   3929       {ECO:0000250}.
FT   DISULFID   3924   3942       {ECO:0000250}.
FT   DISULFID   3936   3951       {ECO:0000250}.
FT   DISULFID   3959   3971       {ECO:0000250}.
FT   DISULFID   3966   3984       {ECO:0000250}.
FT   DISULFID   3978   3995       {ECO:0000250}.
FT   DISULFID   4000   4014       {ECO:0000250}.
FT   DISULFID   4008   4027       {ECO:0000250}.
FT   DISULFID   4021   4040       {ECO:0000250}.
FT   DISULFID   4049   4061       {ECO:0000250}.
FT   DISULFID   4056   4074       {ECO:0000250}.
FT   DISULFID   4068   4083       {ECO:0000250}.
FT   DISULFID   4092   4105       {ECO:0000250}.
FT   DISULFID   4101   4114       {ECO:0000250}.
FT   DISULFID   4116   4130       {ECO:0000250}.
FT   DISULFID   4136   4146       {ECO:0000250}.
FT   DISULFID   4142   4155       {ECO:0000250}.
FT   DISULFID   4157   4175       {ECO:0000250}.
FT   DISULFID   4481   4490       {ECO:0000250}.
FT   DISULFID   4486   4500       {ECO:0000250}.
FT   DISULFID   4502   4514       {ECO:0000250}.
FT   DISULFID   4528   4536       {ECO:0000250}.
FT   DISULFID   4530   4542       {ECO:0000250}.
FT   DISULFID   4544   4553       {ECO:0000250}.
SQ   SEQUENCE   4753 AA;  526425 MW;  CCFC40E397B8D4FC CRC64;
     MILRLLIFTA LAVTTANSST RQQSTFHSIQ VDSPPSVRSR IISASVNTAS SVCNENDFRC
     NDGKCIRTEW KCDGSGDCSD GEDEKDCPHP GCKSDQWQCD TYTWHSVSCI AEYQRCDNIT
     DCADGSDEKD CPASTVDCSS QNVFMCADGR QCFDVSKKCD GKYDCRDLSD EKDSCSRNHT
     ACFQYQFRCA DKTQCIQKSW VCDGSKDCAD GSDEPDTCEF KKCTANEFQC KNKRCQPRKF
     RCDYYDDCGD NSDEDECGEY RCPPGKWNCP GTGHCIDQLK LCDGSKDCAD GADEQQCSQN
     LCPSLGCQAG CHPSPHGGEC TCPSGYKLDD RFHRTCSDIN ECAEFGYCDQ LCANHRPGFT
     CSCLGDCFTL QMEHGPGKDN LTMRGYCVSN NADKMKLFVA RREGLYRLNP KNPDEEVKKL
     ASGEFIYGID FDYGDRKIFW TDRLAHSAFS ADVDDEGEIS QIKKLSLKSL VYPRCLAVDW
     ITNTLYIIES GSRRIDVSSY DGERRTVLLA DGLTLPLDIA LDPLRGEMFF TNQLKLEAAA
     MDGTNRRTLV NTHTHQVSGI VVDITAKRVY WVDPKVDRLE SIDYQGNDRR IVAQGMNVVP
     HPFGLALFDQ YLYWTDWTRL GVIQVEKFGS DTKLLWSNTE NNVFPMGISA YHPMAQPGPG
     QSECLAMKIE NPCTNADCEG MCILSKDNGG FGVGYKCACP IGQKLVNGKR CIDSIDYLLF
     SSNKIVRGIF PEINEKALAE AVLPISPISQ RRIGMYFEVE CDVHGNSFFY ADIMDNTIYR
     IRPDGEGAAP VLVTHNDGLF SMSFDWISKQ LYYVDNIRNS LEVVKIGETG LVHPDELVRR
     QLITELRDPV SVVVHPWKGL LFYAEAMRPA AIYRCHIDGQ NCQVIRNTTL GRPSEMAIDF
     AENRLCWGDT LLKTISCMDF DGKNVVKLDI DNPIPVAITI MNEYIYYVHQ RPYSIRRVHK
     KNGGGSKIVR EFGADERSIF SLKACSHQNQ PIPDDSREHP CRASQCTQLC FATPSESHPN
     ELEAKCACRQ GFMINKENNH SCQKDPAEKI EQLCSSNSTQ FQCKNGRCIP KEWKCDGEND
     CLDESDEIDE KGDKCFHETE CAENTIKCRN TKKCIPAQYG CDGDNDCGDY SDEDVKYCKD
     GQKPVCAAKK FQCDNHRCIP EQWKCDSDND CGDGSDEKLE MCGNATCAAN QFSCANGRCI
     PIYWLCDGDN DCYDGTDEDK ERCPPVQCSA LQFRCANGRQ CVPLRNHCDG QSDCEDGSDE
     DSCAVTAESC TPDQFKCVSS GLCIPASWKC DGQQDCDDGS DEPKFGCTSG RQCSSDQFKC
     GNGRCILNNW LCDGENDCGD GSDESSERGC KTSMNARKCP FEHVACENDQ ETCIPLHQLC
     DGKTHCPGGT DEGGRCARDL CSADRAGCSF KCHNSPNGPI CSCPFGEQLV NKTKCEPENE
     CLDSSSCSQR CKDEKHGFTC SCDEGYELDV DKRTCKVADN VKDTRIYVSN RNRIYYSDHK
     LDNWHTFGAI VENAIALAWD SLTDRIYWSD IREKKILSAN RNGTNATVFI ADGLDITEGI
     ALDWVGRNLY WVDSSLNTIE VANLEDPKQR TLLVHQNVSQ PRGIAVDPRK GVMFWTDWGQ
     NPCIERASMD GTDRQIIVKT KIYWPNTIAL DYTTDRVYFA DSKLDFIDFV NYDGSGRTQV
     LASSKFVQHP HALAIFEDMM YYSDRRLQKL QVYPKYPNGT TSEYPSHTFS KALGVVAVHP
     VLQPVIKNNP CSTNPCSHLC LLNNKNTFTC KCPMGEKLDA SGKKCIDDAK PFLVIIQKTN
     VFGIEMNSAS EKETPVLAGM VPLSGLGNAF DAAYDALSEE MFILEHTNHA KTLAQITTDS
     AIYRSTVNGG NKTKMFSSAV PDDAYCLGFD WNGRNLVVGN KITQTIEIIR TQGKQYRSVI
     LSNDQSPTAV VTPVAIAVDA DKGYVFWLDR GGGAADAKVA RAGLDGSNPL VIASNDLAEL
     DHIAIDTTNT RVYFSEAKAG RISSVTYDGQ DRHYVLSDGG RQPNGLAFYG DRLFYADSAF
     DSIEVATING DSQPPQWTHF KKDVENLANI KALQPRASSS GHPCHINNGN CDHICIPLMF
     AQRTCTCANG YVKDGQTSCK LFDESFVIVA TKTKVIGYPI DETQSKGVAM EPIGGLSITG
     VDYDYESKTI YVAEASGINK GITAYTIGES SPRAVIRDSI GSLTIKSLAI DWINYNMYFI
     NHDAERTNIE VSKLDGTYRK ILLTTKTETP SSIAVDPVSR YLYWADQGQK PTIQRSFLDG
     SRREVIVSSG IAEPTDLVVD VASKMIYWSD AKMDGIYRVR STGGTPELVR SDIASAAGVA
     LHGQNMYWTD NRLEKLFRAT SKPNQTSLLL SPTTVAASLK DIGDVAVFSS NNQPRASSPC
     QITDNLRKSP CTQLCFATPG TQTPTCSCAR GVLKGRTCEE PDTYIMFSDG DKIIDVAIEP
     DVKASRPLKD PFPEISNLQT FDVDVNLRRV YFVVESPVGV NISWFSMNNA ENPRLVFGAS
     KQPHAKEIRH ISDMKLDWLT QKIYFTTGRG GKVMAIDTAG EHLSTIASGD WTYALAIDPC
     SGLLFWSDSG YKTSGGLYEP RIERSNLAGG SRKVIVSESI SLPAAIAVDF RNQKIYWADV
     NRLNIEVADY DGQNRKVIAS GYRAKSLDIW DRWLYMSDPL SNGVFRIDKE SGSGLENVVS
     DRRIPGALRV FASESDVRTR NQVCNALTSQ LCKTDNGGCD QLCTVVADDI GLAASKVQCS
     CNDTYELVQE PGKDYPTQCV LRGSNSEPAK ECLPPYNFQC GDGSCILLGA TCDSKPDCAD
     ASDENPNYCN TRSCPEDYNL CTNRRCIDSA KKCNHIDDCG DGSDELDCPS AVACAEGTFP
     CSNGHCINQT KVCDGHNDCH DEQVSDESLA TCPGLPIDCR GVKVRCPNTN ICIQPADLCD
     GYDDCGDKAD ENQLFCMNQQ CAQHYVRCPS GRCIPETWQC DGDNDCSDGW DETHTNCTDT
     AGKKICVGDY LFQCDNLKCI SRAFICDGED DCGDGSDEHS RHGCGNRTCT DQEFHCTSNA
     KLAQPKYECI PRAWLCDGDV TCAGGEDEST ELCKTEKKEC NKGEFRCSNQ HCIHSTWECD
     GDNDCLDGSD EHANCTYSSC QPDFFQCANH KCVPNSWKCD GNDDCEDGSD EKDCPKNSAS
     AQKASKCSNG QFQCTSGECI DDAKVCDRNF DCTDRSDESS LCFIDECSLA EKPLCEQKCM
     DMKIGYKCDC FEGFAIDISD QKSCHNVNEC YEGISGCSQK CDDKIGSYKC GCVDGYQLSS
     DDHSCKRTEM EPEPFFLLAN KHYIRKISID GNKYELAAQG FDNVVSLDID LTEKKAYLID
     QGKLRLLRVD LDEMDSPLSS YETVLRHNVY GTEGIAVDWV GRKLYMLNRQ ERSIRVCELD
     GRFCKTLIRD RIQQPKAIVV HPGKGYLFFT EWSLQPYIGR IALDGSPELQ DPIFKLAEHD
     LGWPNAIAID YFSDRLFWGD AHLNEIGFMD FDGNGRRHIP AQRTSHVSSM VVFDDYLYWA
     DWNLREVLRC DKWTGKNETI LKKTVQLPND LRIVHPMRQP AYPNPCGDNN GGCSHLCLIG
     AGGNGYTCSC PDQFVLLSDQ KTCEPNCTER QFACGGDDAK CIPKLWYCDG EPDCRDGSDE
     PGESICGQRI CPVGEFQCTN HNCTRPFQIC DGNDDCGDSS DEQNCDKACD PWMFKCAATG
     RCIPRRFTCD GDDDCGDRSD EADTLCMSAE RNCTAEEFRC NNNKCIAKAW RCDNDDDCGD
     GSDETPECAQ IECKKGWTRC SSSYRCIPNW AFCNGQDDCR DNSDEDKQRC PTCDDVGEFR
     CATSGKCIPR RWMCDTENDC GDNSDELDAS CGGTTRPCSE SEFRCNDGKC IPGSKVCDGT
     IQCSDGLDES QCTLRRCLPG HRQCDDGTCI AEHKWCDRKK DCPNAADELH CEDVSRRTCS
     PFEFECANSV CIPRKFMCDG DNDCGDNSDE TSSECRSAQC DPPLRFRCAH SRLCLNILQL
     CNGFNDCGPN DFSDEHLSMC SSFSEYGDCS SDQFKCANGK CVNGTVACDR KDDCGDASDE
     IGCSKHGGKT SCEAFGNNGG CKHICTDVRD GFYCHCRDGF RPDPQSPKEC IDIDECAGNN
     TCTQLCLNTK GSYLCRCHED YENNVVVGSM TGKDCRAKGD AANVMIGADD SLVQLSLHGS
     GTNRHAAAKA NDDDNDIIGI AFDPRKELMY WIDGSERTIY RSAIANGNQS HEGQKLDVDF
     AAMGVVPTAI AVDYTTGNLF IAAVSENIEN GLVTARKKRM SEPIDNQNTG FIFVCLPDGR
     YLKKIVAGHL QQPTALITAP SAGRICYSDA GLHAKIECAD MDGTHRQIIV KDLVFSPTSM
     AIDEGKGNRI YWVDPKYRRV DAVNIDGSER TTVVHDRHIP YAVDVFENHI YWLSRESKTL
     YVQDKFGRGR VSVLASDLED GHTVRVSQKY AKDTQRTVSG CERAQCSHLC VSLPSTGFAC
     LCPDGIVPQL DGSCATQHVE ALTMPKQCKC TNGGKCRLDG SCECTSDFEG DQCEKESSVS
     RKIIGTLSEN FITVLLYILA FLFAFGLIGF CALNLYKRRQ LLFKKNEAAD GSVSFHGNVI
     SFSNPVLENK QDAPGSEFNM QQMTSMHDDS TTFTNPVYEL EDVDMSSPPP SNDQPSTSAS
     AMSPNRPSTS AASSFVPPTF DQDEIELKTA DEIIVPKAEI SKPPIPARPK KEKADPLRVD
     NPLYDPDSEV SDV
//
DBGET integrated database retrieval system