ID Q04DY2_OENOB Unreviewed; 679 AA.
AC Q04DY2;
DT 14-NOV-2006, integrated into UniProtKB/TrEMBL.
DT 14-NOV-2006, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE RecName: Full=transketolase {ECO:0000256|ARBA:ARBA00013152};
DE EC=2.2.1.1 {ECO:0000256|ARBA:ARBA00013152};
GN OrderedLocusNames=OEOE_1480 {ECO:0000313|EMBL:ABJ57340.1};
OS Oenococcus oeni (strain ATCC BAA-331 / PSU-1).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Lactobacillaceae;
OC Oenococcus.
OX NCBI_TaxID=203123 {ECO:0000313|EMBL:ABJ57340.1, ECO:0000313|Proteomes:UP000000774};
RN [1] {ECO:0000313|EMBL:ABJ57340.1, ECO:0000313|Proteomes:UP000000774}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-331 / PSU-1 {ECO:0000313|Proteomes:UP000000774};
RX PubMed=17030793; DOI=10.1073/pnas.0607117103;
RA Makarova K., Slesarev A., Wolf Y., Sorokin A., Mirkin B., Koonin E.,
RA Pavlov A., Pavlova N., Karamychev V., Polouchine N., Shakhova V.,
RA Grigoriev I., Lou Y., Rohksar D., Lucas S., Huang K., Goodstein D.M.,
RA Hawkins T., Plengvidhya V., Welker D., Hughes J., Goh Y., Benson A.,
RA Baldwin K., Lee J.H., Diaz-Muniz I., Dosti B., Smeianov V., Wechter W.,
RA Barabote R., Lorca G., Altermann E., Barrangou R., Ganesan B., Xie Y.,
RA Rawsthorne H., Tamir D., Parker C., Breidt F., Broadbent J., Hutkins R.,
RA O'Sullivan D., Steele J., Unlu G., Saier M., Klaenhammer T., Richardson P.,
RA Kozyavkin S., Weimer B., Mills D.;
RT "Comparative genomics of the lactic acid bacteria.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:15611-15616(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate =
CC aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate;
CC Xref=Rhea:RHEA:10508, ChEBI:CHEBI:57483, ChEBI:CHEBI:57737,
CC ChEBI:CHEBI:58273, ChEBI:CHEBI:59776; EC=2.2.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001027};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- SIMILARITY: Belongs to the transketolase family.
CC {ECO:0000256|ARBA:ARBA00007131}.
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DR EMBL; CP000411; ABJ57340.1; -; Genomic_DNA.
DR RefSeq; WP_002821710.1; NC_008528.1.
DR AlphaFoldDB; Q04DY2; -.
DR STRING; 203123.OEOE_1480; -.
DR KEGG; ooe:OEOE_1480; -.
DR PATRIC; fig|203123.7.peg.1499; -.
DR eggNOG; COG0021; Bacteria.
DR HOGENOM; CLU_009227_0_0_9; -.
DR Proteomes; UP000000774; Chromosome.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004802; F:transketolase activity; IEA:UniProtKB-EC.
DR CDD; cd07033; TPP_PYR_DXS_TK_like; 1.
DR CDD; cd02012; TPP_TK; 1.
DR Gene3D; 3.40.50.920; -; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR009014; Transketo_C/PFOR_II.
DR InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR InterPro; IPR005478; Transketolase_bac-like.
DR InterPro; IPR033248; Transketolase_C.
DR InterPro; IPR033247; Transketolase_fam.
DR InterPro; IPR005474; Transketolase_N.
DR NCBIfam; TIGR00232; tktlase_bact; 1.
DR PANTHER; PTHR43522; TRANSKETOLASE; 1.
DR PANTHER; PTHR43522:SF2; TRANSKETOLASE 1-RELATED; 1.
DR Pfam; PF02779; Transket_pyr; 1.
DR Pfam; PF02780; Transketolase_C; 1.
DR Pfam; PF00456; Transketolase_N; 1.
DR SMART; SM00861; Transket_pyr; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000000774};
KW Transferase {ECO:0000313|EMBL:ABJ57340.1}.
FT DOMAIN 361..532
FT /note="Transketolase-like pyrimidine-binding"
FT /evidence="ECO:0000259|SMART:SM00861"
SQ SEQUENCE 679 AA; 75726 MW; C1E57442B3F26D1E CRC64;
MIDTQFENIP LKELNRQDEQ QAVNAIRFLS LDMIQKANSG HPGLPLDAAP MAYTLFQKFL
NFNNRDPYWI NRDRFVLSAG HGSALLYSLL HLNGFKVGID DLKRFRQLDS LTPGHPEWKH
TPGIDATTGP LGQGLTMAVG MAMAEKHLSA IYNRPGFNIF DHETYVIVGD GDLMEGISQE
SMAIAGEKRL SKLIVLFDSN DVSLDGSLKL STGEKIQDRI IGNGWDYQFV ADGNNLSDID
EAIREAKKSD KPSFIEIKTI IGYGTPLQGS SKVHGAAIGE ENVAKTRDFY HWPYQPFEIP
KDVYDLFNDS HQAKDRYYKS WQESFQLYAE AFPRLAEQLE NNDSTLNTDN LKLAENNDQE
LATRVSSSEV MQQIADQNRT FWGGSADLSS SNKTYLKDQG DFTDLTPQGS NVFYGVREFA
MAAITNGILL HGNSRAFAST FFIFSDYMKP AIRLAALQKL ASIFIFSHDS LAVGEDGPTH
QPVEQLETLR TTPGIDVYRP ADQNETLAAW KAIAKTTNRP TALVTSRQKL PVLRETKDAP
VERGAYIVSS AKKDLPDAIL IASGSELHLA LEAKRELEKE GYDLSVVSMP SMEAFQRQSE
EYQASVLPKQ VVNRLSIEMA SSLAWGRYTG IFGKNLAVDT FGKSGKANDV IDDYGFNLAH
ISRMVKKMID ENKNLQIVK
//
