GenomeNet

Database: UniProt
Entry: Q06709
LinkDB: Q06709
Original site: Q06709 
ID   REH1_YEAST              Reviewed;         432 AA.
AC   Q06709; D6VZ22; Q7LIF0;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   24-JAN-2024, entry version 162.
DE   RecName: Full=Cytoplasmic 60S subunit biogenesis factor REH1;
DE   AltName: Full=REI1-homolog 1;
DE   AltName: Full=pre-60S factor REH1;
GN   Name=REH1; OrderedLocusNames=YLR387C;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169871;
RA   Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA   Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA   Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA   Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA   Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA   Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA   Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA   Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA   Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA   Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA   Zollner A., Hani J., Hoheisel J.D.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL   Nature 387:87-90(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=17322287; DOI=10.1101/gr.6037607;
RA   Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA   Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA   Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA   Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA   LaBaer J.;
RT   "Approaching a complete repository of sequence-verified protein-encoding
RT   clones for Saccharomyces cerevisiae.";
RL   Genome Res. 17:536-543(2007).
RN   [4]
RP   DOMAIN.
RX   PubMed=9171100; DOI=10.1093/nar/25.12.2464;
RA   Boehm S., Frishman D., Mewes H.-W.;
RT   "Variations of the C2H2 zinc finger motif in the yeast genome and
RT   classification of yeast zinc finger proteins.";
RL   Nucleic Acids Res. 25:2464-2469(1997).
RN   [5]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=14562095; DOI=10.1038/nature02026;
RA   Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA   Weissman J.S., O'Shea E.K.;
RT   "Global analysis of protein localization in budding yeast.";
RL   Nature 425:686-691(2003).
RN   [6]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [7]
RP   FUNCTION, ASSOCIATION WITH PRE-60S PARTICLES, AND INTERACTION WITH NMD3;
RP   LSG1 AND TIF6.
RX   PubMed=19433447; DOI=10.1128/mcb.01582-08;
RA   Parnell K.M., Bass B.L.;
RT   "Functional redundancy of yeast proteins Reh1 and Rei1 in cytoplasmic 60S
RT   subunit maturation.";
RL   Mol. Cell. Biol. 29:4014-4023(2009).
CC   -!- FUNCTION: Pre-60S-associated cytoplasmic factor involved in the
CC       cytoplasmic maturation of the 60S subunit. May act redundantly with
CC       REI1 to directly promote a stabilizing structural rearrangement in
CC       cytoplasmic 60S subunit maturation independent on the REI1-specific
CC       ARX1 recycling. {ECO:0000269|PubMed:19433447}.
CC   -!- SUBUNIT: Associates with nascent pre-60S particles that have not yet
CC       entered the translating pool, and is released from mature 60S subunits.
CC       Interacts with pre-60S factors NMD3, LSG1, and TIF6.
CC       {ECO:0000269|PubMed:19433447}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}.
CC   -!- MISCELLANEOUS: Present with 2240 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the REI1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U19104; AAB67280.1; -; Genomic_DNA.
DR   EMBL; U19729; AAB82362.1; -; Genomic_DNA.
DR   EMBL; AY692733; AAT92752.1; -; Genomic_DNA.
DR   EMBL; BK006945; DAA09688.1; -; Genomic_DNA.
DR   PIR; S51474; S51474.
DR   RefSeq; NP_013491.1; NM_001182276.1.
DR   PDB; 5H4P; EM; 3.07 A; z=377-432.
DR   PDB; 6QIK; EM; 3.10 A; z=1-432.
DR   PDB; 6QT0; EM; 3.40 A; z=1-432.
DR   PDB; 6QTZ; EM; 3.50 A; z=1-432.
DR   PDB; 6RI5; EM; 3.30 A; z=1-432.
DR   PDB; 6S05; EM; 3.90 A; z=1-432.
DR   PDBsum; 5H4P; -.
DR   PDBsum; 6QIK; -.
DR   PDBsum; 6QT0; -.
DR   PDBsum; 6QTZ; -.
DR   PDBsum; 6RI5; -.
DR   PDBsum; 6S05; -.
DR   AlphaFoldDB; Q06709; -.
DR   EMDB; EMD-10071; -.
DR   EMDB; EMD-4560; -.
DR   EMDB; EMD-4630; -.
DR   EMDB; EMD-4636; -.
DR   EMDB; EMD-4884; -.
DR   SMR; Q06709; -.
DR   BioGRID; 31646; 64.
DR   DIP; DIP-4235N; -.
DR   IntAct; Q06709; 2.
DR   MINT; Q06709; -.
DR   STRING; 4932.YLR387C; -.
DR   iPTMnet; Q06709; -.
DR   MaxQB; Q06709; -.
DR   PaxDb; 4932-YLR387C; -.
DR   PeptideAtlas; Q06709; -.
DR   EnsemblFungi; YLR387C_mRNA; YLR387C; YLR387C.
DR   GeneID; 851103; -.
DR   KEGG; sce:YLR387C; -.
DR   AGR; SGD:S000004379; -.
DR   SGD; S000004379; REH1.
DR   VEuPathDB; FungiDB:YLR387C; -.
DR   eggNOG; KOG2785; Eukaryota.
DR   GeneTree; ENSGT00390000018047; -.
DR   HOGENOM; CLU_018787_1_1_1; -.
DR   InParanoid; Q06709; -.
DR   OMA; QRYHMKT; -.
DR   OrthoDB; 180831at2759; -.
DR   BioCyc; YEAST:G3O-32453-MONOMER; -.
DR   BioGRID-ORCS; 851103; 0 hits in 10 CRISPR screens.
DR   PRO; PR:Q06709; -.
DR   Proteomes; UP000002311; Chromosome XII.
DR   RNAct; Q06709; Protein.
DR   GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IGI:SGD.
DR   InterPro; IPR041661; ZN622/Rei1/Reh1_Znf-C2H2.
DR   InterPro; IPR040025; Znf622/Rei1/Reh1.
DR   PANTHER; PTHR13182; ZINC FINGER PROTEIN 622; 1.
DR   PANTHER; PTHR13182:SF8; ZINC FINGER PROTEIN 622; 1.
DR   Pfam; PF12756; zf-C2H2_2; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Metal-binding; Reference proteome; Repeat;
KW   Ribosome biogenesis; Zinc; Zinc-finger.
FT   CHAIN           1..432
FT                   /note="Cytoplasmic 60S subunit biogenesis factor REH1"
FT                   /id="PRO_0000268700"
FT   ZN_FING         6..30
FT                   /note="C2H2-type 1"
FT   ZN_FING         186..209
FT                   /note="C2H2-type 2"
FT   ZN_FING         237..261
FT                   /note="C2H2-type 3"
FT   REGION          79..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        88..102
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        117..150
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   432 AA;  49690 MW;  1E4051797FD7D38A CRC64;
     MSSTFFTCNC CVIQFKTSDL QRYHMKTEWH RYNLKRRIAN LPPIGAEQFA EKLQISEKEQ
     AENQVDEFGF PVLKPVMNQS NALPQKQKKP IKSKRGRKVG TNLLKRKDRD IAKEKQNRSV
     SPSGSISSQL SNLTVGTENT NTDYGEDTVS EYGFTSDSNY EYATSDEELD IADKPSDKEN
     EKITITECIY CGKDNKEVER NVKHMFSEHG LFIPERSYLI DLNGLLEFLI KMIVIDHNCL
     CCNFHGSGLE SIRAHMASKR HCRLPYETKE ERQLFAPFYD FTYDDHSISK NLQNDRAITS
     KLSSVYGAKN DEEDGEVDIT LVSSENDINA NYTTVSIDES GLELTLPTGA RLGHRAGQRY
     YRQNLPSQPN PNESRRTITA ADRRMVSGVT EKQYKKGMKK MQQLEKNAIN TQIRREIKRV
     NFQTHYRDEL LQ
//
DBGET integrated database retrieval system