ID ASA1_YEAST Reviewed; 443 AA.
AC Q06822; D6W487;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2006, sequence version 2.
DT 27-MAR-2024, entry version 154.
DE RecName: Full=ASTRA-associated protein 1;
GN Name=ASA1; OrderedLocusNames=YPR085C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169875;
RA Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W.,
RA Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D.,
RA Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E.,
RA Churcher C.M., Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H.,
RA DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N.,
RA Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K.,
RA Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M.,
RA Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A.,
RA Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S.,
RA Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D.,
RA Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S.,
RA Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B.,
RA Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A.,
RA Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R.,
RA Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A.,
RA Vo D.H., Hani J.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.";
RL Nature 387:103-105(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP IDENTIFICATION IN THE ASTRA COMPLEX, AND IDENTIFICATION BY MASS
RP SPECTROMETRY.
RX PubMed=19040720; DOI=10.1186/gb-2008-9-11-r167;
RA Shevchenko A., Roguev A., Schaft D., Buchanan L., Habermann B., Sakalar C.,
RA Thomas H., Krogan N.J., Shevchenko A., Stewart A.F.;
RT "Chromatin Central: towards the comparative proteome by accurate mapping of
RT the yeast proteomic environment.";
RL Genome Biol. 9:R167.1-R167.22(2008).
RN [4]
RP IDENTIFICATION OF PROBABLE INITIATION SITE.
RX PubMed=12748633; DOI=10.1038/nature01644;
RA Kellis M., Patterson N., Endrizzi M., Birren B.W., Lander E.S.;
RT "Sequencing and comparison of yeast species to identify genes and
RT regulatory elements.";
RL Nature 423:241-254(2003).
CC -!- FUNCTION: Component of the ASTRA complex involved in chromatin
CC remodeling.
CC -!- SUBUNIT: Component of the ASTRA chromatin-remodeling machinery complex
CC composed of at least ASA1, RVB1, RVB2, TRA1, TEL2, TT1 and TTI2.
CC {ECO:0000269|PubMed:19040720}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat ASA1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB68134.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; U51033; AAB68134.1; ALT_INIT; Genomic_DNA.
DR EMBL; BK006949; DAA11503.1; -; Genomic_DNA.
DR PIR; S69071; S69071.
DR RefSeq; NP_015410.2; NM_001184182.1.
DR AlphaFoldDB; Q06822; -.
DR BioGRID; 36256; 547.
DR DIP; DIP-3886N; -.
DR IntAct; Q06822; 3.
DR STRING; 4932.YPR085C; -.
DR MaxQB; Q06822; -.
DR PaxDb; 4932-YPR085C; -.
DR PeptideAtlas; Q06822; -.
DR EnsemblFungi; YPR085C_mRNA; YPR085C; YPR085C.
DR GeneID; 856200; -.
DR KEGG; sce:YPR085C; -.
DR AGR; SGD:S000006289; -.
DR SGD; S000006289; ASA1.
DR VEuPathDB; FungiDB:YPR085C; -.
DR eggNOG; ENOG502QU4T; Eukaryota.
DR HOGENOM; CLU_045414_1_0_1; -.
DR InParanoid; Q06822; -.
DR OMA; LVCCNTQ; -.
DR OrthoDB; 5476119at2759; -.
DR BioCyc; YEAST:G3O-34229-MONOMER; -.
DR BioGRID-ORCS; 856200; 0 hits in 10 CRISPR screens.
DR PRO; PR:Q06822; -.
DR Proteomes; UP000002311; Chromosome XVI.
DR RNAct; Q06822; Protein.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 1: Evidence at protein level;
KW Chromatin regulator; Nucleus; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..443
FT /note="ASTRA-associated protein 1"
FT /id="PRO_0000252299"
FT REPEAT 23..67
FT /note="WD 1"
FT REPEAT 71..110
FT /note="WD 2"
FT REPEAT 258..295
FT /note="WD 3"
FT REPEAT 318..359
FT /note="WD 4"
FT REGION 372..391
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 443 AA; 50563 MW; 2EF7AC0A161DED82 CRC64;
MRGFSNEIIL KRTLTLSDFT LRYHKRGITA LQVIKAPSVS NVPVLLSGDN YGYFVMWDLV
TKRPITHIEI EGNSHIIAFW WVETTNVLYI LSKDSMLRIF ELDSSTQLSI DLVRKLSQAN
KTDHLQWTKI YEMPINTLNF ANFIIEAEVK PTKDNKSYRL VCCHTDDSET IDIYQIIEDS
TFKLKRPFNN INFPRFLKQQ NFLGISKDSK FGIIMRFAKL NDVIFLGYEN GFVVGFKITF
DEGLQRDIAE LVHVSNDHYP NPILDMCVSG DELYSCSTDD FITKYKIPVN LQLETKYLRD
DALLIKCPSS LRVSEPSKVH LPLKNIGHID KVKDDYLVVS SWSGMTIVYN MRTSEVEQTF
VKSKNNLVVS DSSMGDLTNG SGSNTESSSK SHNYKVGAMT CLESFDVQSD GLRLGQLRRI
KALAKCNWCL IGYEDGTIKL NKI
//
