ID Q06W28_DANRE Unreviewed; 230 AA.
AC Q06W28; A0A8M1P5J4;
DT 31-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 31-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 114.
DE SubName: Full=Sodium channel subunit beta-2 {ECO:0000313|RefSeq:NP_001333341.1};
DE SubName: Full=Sodium channel, voltage-gated, type II, beta {ECO:0000313|Ensembl:ENSDARP00000131257};
DE SubName: Full=Voltage-gated sodium channel beta 2 subunit splice variant D {ECO:0000313|EMBL:ABF47243.1};
GN Name=scn2b {ECO:0000313|Ensembl:ENSDARP00000131257,
GN ECO:0000313|RefSeq:NP_001333341.1,
GN ECO:0000313|ZFIN:ZDB-GENE-070920-1};
GN Synonyms=SCN2B {ECO:0000313|EMBL:ABF47243.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|EMBL:ABF47243.1};
RN [1] {ECO:0000313|EMBL:ABF47243.1, ECO:0000313|RefSeq:NP_001333341.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001333341.1};
RX PubMed=17623065; DOI=10.1186/1471-2148-7-113;
RA Chopra S.S., Watanabe H., Zhong T.P., Roden D.M.;
RT "Molecular cloning and analysis of zebrafish voltage-gated sodium channel
RT beta subunit genes: implications for the evolution of electrical signaling
RT in vertebrates.";
RL BMC Evol. Biol. 7:113-113(2007).
RN [2] {ECO:0000313|RefSeq:NP_001333341.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001333341.1};
RX PubMed=21906622; DOI=10.1016/j.dci.2011.08.006;
RA Grayfer L., Belosevic M.;
RT "Identification and molecular characterization of the interleukin-10
RT receptor 1 of the zebrafish (Danio rerio) and the goldfish (Carassius
RT auratus L.).";
RL Dev. Comp. Immunol. 36:408-417(2012).
RN [3] {ECO:0000313|RefSeq:NP_001333341.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001333341.1};
RX PubMed=24002024;
RA Baraban S.C., Dinday M.T., Hortopan G.A.;
RT "Drug screening in Scn1a zebrafish mutant identifies clemizole as a
RT potential Dravet syndrome treatment.";
RL Nat. Commun. 4:2410-2410(2013).
RN [4] {ECO:0000313|Ensembl:ENSDARP00000131257, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000131257};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|Ensembl:ENSDARP00000131257}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000131257};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [6] {ECO:0000313|RefSeq:NP_001333341.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001333341.1};
RX PubMed=27189481;
RA Pasquier J., Cabau C., Nguyen T., Jouanno E., Severac D., Braasch I.,
RA Journot L., Pontarotti P., Klopp C., Postlethwait J.H., Guiguen Y.,
RA Bobe J.;
RT "Gene evolution and gene expression after whole genome duplication in fish:
RT the PhyloFish database.";
RL BMC Genomics 17:368-368(2016).
RN [7] {ECO:0000313|RefSeq:NP_001333341.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001333341.1};
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [8] {ECO:0000313|RefSeq:NP_001333341.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001333341.1};
RX PubMed=31031593;
RA Tsata V., Kroehne V., Reinhardt S., El-Armouche A., Brand M., Wagner M.,
RA Reimer M.M.;
RT "Electrophysiological Properties of Adult Zebrafish Oligodendrocyte
RT Progenitor Cells.";
RL Front. Cell. Neurosci. 13:102-102(2019).
RN [9] {ECO:0000313|RefSeq:NP_001333341.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:NP_001333341.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CU019627; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; DQ489729; ABF47243.1; -; mRNA.
DR RefSeq; NP_001333341.1; NM_001346412.1.
DR STRING; 7955.ENSDARP00000131257; -.
DR PaxDb; 7955-ENSDARP00000092068; -.
DR Ensembl; ENSDART00000162807.2; ENSDARP00000131257.1; ENSDARG00000101713.2.
DR GeneID; 777666; -.
DR KEGG; dre:777666; -.
DR AGR; ZFIN:ZDB-GENE-070920-1; -.
DR CTD; 6327; -.
DR ZFIN; ZDB-GENE-070920-1; scn2b.
DR eggNOG; ENOG502R29H; Eukaryota.
DR HOGENOM; CLU_090350_0_0_1; -.
DR OMA; RLACTFN; -.
DR OrthoDB; 5311693at2759; -.
DR TreeFam; TF331728; -.
DR Reactome; R-DRE-198933; Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
DR Reactome; R-DRE-202733; Cell surface interactions at the vascular wall.
DR Proteomes; UP000000437; Chromosome 15.
DR Bgee; ENSDARG00000101713; Expressed in brain and 9 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR000920; Myelin_P0-rel.
DR PANTHER; PTHR13869; MYELIN P0 RELATED; 1.
DR PANTHER; PTHR13869:SF3; SODIUM CHANNEL SUBUNIT BETA-2; 1.
DR Pfam; PF07686; V-set; 1.
DR PRINTS; PR00213; MYELINP0.
DR SMART; SM00409; IG; 1.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion channel {ECO:0000313|EMBL:ABF47243.1,
KW ECO:0000313|RefSeq:NP_001333341.1};
KW Ion transport {ECO:0000313|EMBL:ABF47243.1,
KW ECO:0000313|RefSeq:NP_001333341.1}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000313|EMBL:ABF47243.1, ECO:0000313|RefSeq:NP_001333341.1}.
FT TRANSMEM 21..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..186
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 30..154
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 201..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 230 AA; 25467 MW; 7CFB1030C54DE46F CRC64;
MLISLHSGET QWASALKLSC VAMVMFLACP VMSMDVLVPA LINALNGSDV RITCTFTSCY
KLDPSKFAMN WTYQETSNST EEMFMTYKNT YKMIPLKPSR FGERVMFTGN LDKNDLSITI
SDVQLTDEGI YNCYVRNPPD RIQGHGTIQF AVLTELPPPR DSTIAVAIGA SVGGILALLI
LSMVVVKCIR RHKNQELISD EQKMEEEGKV DGEGGTEEAT KNLSLLPEDI
//
