GenomeNet

Database: UniProt
Entry: Q07441
LinkDB: Q07441
Original site: Q07441 
ID   ITB5_PAPCY              Reviewed;         655 AA.
AC   Q07441;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   13-FEB-2019, entry version 102.
DE   RecName: Full=Integrin beta-5;
DE   Flags: Fragment;
GN   Name=ITGB5;
OS   Papio cynocephalus (Yellow baboon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Papio.
OX   NCBI_TaxID=9556;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8224922; DOI=10.1016/0378-1119(93)90659-Q;
RA   Shoji M., Hayzer D.J., Kim T.M., Runge M.S., Hanson S.R.;
RT   "Human and baboon integrin beta 5 subunit-encoding mRNAs have
RT   alternative polyadenylation sites.";
RL   Gene 133:307-308(1993).
CC   -!- FUNCTION: Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for
CC       fibronectin. It recognizes the sequence R-G-D in its ligand.
CC   -!- SUBUNIT: Heterodimer of an alpha and a beta subunit. Beta-5
CC       (ITGB5) associates with alpha-V (ITGAV). Interacts with MYO10.
CC       Interacts with DAB2. Integrin ITGAV:ITGB5 interacts with FBLN5
CC       (via N-terminus) (By similarity). ITGAV:ITGB5 interacts with CCN3
CC       (By similarity). {ECO:0000250|UniProtKB:O70309,
CC       ECO:0000250|UniProtKB:P18084}.
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein.
CC   -!- PTM: The cysteine residues are involved in intrachain disulfide
CC       bonds.
CC   -!- SIMILARITY: Belongs to the integrin beta chain family.
CC       {ECO:0000305}.
DR   EMBL; L12231; AAA16866.1; -; mRNA.
DR   ProteinModelPortal; Q07441; -.
DR   SMR; Q07441; -.
DR   PRIDE; Q07441; -.
DR   HOVERGEN; HBG006190; -.
DR   GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR   GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.410; -; 1.
DR   InterPro; IPR040622; I-EGF_1.
DR   InterPro; IPR027067; Integrin_beta-5.
DR   InterPro; IPR015812; Integrin_bsu.
DR   InterPro; IPR014836; Integrin_bsu_cyt_dom.
DR   InterPro; IPR012896; Integrin_bsu_tail.
DR   InterPro; IPR036349; Integrin_bsu_tail_dom_sf.
DR   InterPro; IPR002369; Integrin_bsu_VWA.
DR   InterPro; IPR032695; Integrin_dom_sf.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10082; PTHR10082; 1.
DR   PANTHER; PTHR10082:SF26; PTHR10082:SF26; 1.
DR   Pfam; PF18372; I-EGF_1; 1.
DR   Pfam; PF08725; Integrin_b_cyt; 1.
DR   Pfam; PF07965; Integrin_B_tail; 1.
DR   Pfam; PF00362; Integrin_beta; 1.
DR   PRINTS; PR01186; INTEGRINB.
DR   SMART; SM00187; INB; 1.
DR   SMART; SM01241; Integrin_b_cyt; 1.
DR   SMART; SM01242; Integrin_B_tail; 1.
DR   SUPFAM; SSF53300; SSF53300; 1.
DR   SUPFAM; SSF69179; SSF69179; 1.
DR   SUPFAM; SSF69687; SSF69687; 1.
DR   PROSITE; PS00022; EGF_1; 2.
DR   PROSITE; PS01186; EGF_2; 2.
DR   PROSITE; PS00243; INTEGRIN_BETA; 2.
PE   2: Evidence at transcript level;
KW   Cell adhesion; Disulfide bond; Glycoprotein; Integrin; Membrane;
KW   Phosphoprotein; Receptor; Repeat; Transmembrane; Transmembrane helix.
FT   CHAIN        <1    655       Integrin beta-5.
FT                                /FTId=PRO_0000174222.
FT   TOPO_DOM     <1    575       Extracellular. {ECO:0000255}.
FT   TRANSMEM    576    598       Helical. {ECO:0000255}.
FT   TOPO_DOM    599    655       Cytoplasmic. {ECO:0000255}.
FT   DOMAIN       <1    234       VWFA.
FT   REPEAT      321    368       I.
FT   REPEAT      369    410       II.
FT   REPEAT      411    449       III.
FT   REPEAT      450    486       IV.
FT   REGION      457    621       Cysteine-rich tandem repeats.
FT   MOD_RES     626    626       Phosphoserine.
FT                                {ECO:0000250|UniProtKB:P18084}.
FT   CARBOHYD    203    203       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    316    316       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    408    408       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    442    442       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    510    510       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   CARBOHYD    561    561       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000255}.
FT   NON_TER       1      1
SQ   SEQUENCE   655 AA;  72466 MW;  BAC33A159CBE1596 CRC64;
     DLSLSMKDDL DTIRNLGTKL AEEMRKLTSN FRLGFGSFVD KDISPFSYTA PRYQTNPCIG
     YKLFPNCVPS FGFRHLLPLT DRVDSFNEEV RKQRVSRNRD APEGCFDAVL QAAVCKEKIG
     WRKDALHLLV FTTDDVPHIA LDGKLGGLVQ PHDGQCHLNE ANEYTASNQM DYPSLALLGE
     KLAENNINLI FAVTKNHYML YKNFTALIPG TTVEILDGDS KNIIQLIINA YNSIRSKVEL
     SVWDQPEDLN LFFTATCQDG VSYPGQRKCE GLKIGDTASF EVSVEARSCP SRHTEHVFAL
     QPVGCRDSLE VGVTYNCTCG CSVGLEPNSA RCSGTGTYVC GLCECSPGYL GTRCECQDGE
     NHSVYQNLCR DTEGKPLCSG RGDCSCNQCS CFESEFGKIY GPFCECDNFS CARNKGVLCS
     GHGECHCGEC KCHAGYIGDN CNCSTDISTC RGRDGQICSE RGHCLCGQCQ CTEPGAFGEM
     CEKCPTCPDA CSTKRDCVEC PLLHSGKPDN QTCHSLCRDE VITWVDTIVK DDQEAVLCFY
     KTAKDCVMMF TYVELPSGKS NLTVLREPEC GNTPNAMTIL LAVVGSILLV GLALLAIWKL
     LVTIHDRREF AKFQSERSRA RYEMASNPLY RKPISTHTVD FTFNKFNKSY NGTVD
//
DBGET integrated database retrieval system