ID YAG1_SCHPO Reviewed; 905 AA.
AC Q09866; Q9UUH9;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 27-MAR-2002, sequence version 2.
DT 24-JAN-2024, entry version 131.
DE RecName: Full=Uncharacterized WD repeat-containing protein C12G12.01c;
GN ORFNames=SPAC12G12.01c, SPAC630.02;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-394 AND SER-397, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18257517; DOI=10.1021/pr7006335;
RA Wilson-Grady J.T., Villen J., Gygi S.P.;
RT "Phosphoproteome analysis of fission yeast.";
RL J. Proteome Res. 7:1088-1097(2008).
CC -!- SIMILARITY: Belongs to the WD repeat mio family. {ECO:0000305}.
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DR EMBL; CU329670; CAA91496.1; -; Genomic_DNA.
DR PIR; T38980; T38980.
DR RefSeq; XP_001713039.1; XM_001712987.2.
DR AlphaFoldDB; Q09866; -.
DR SMR; Q09866; -.
DR BioGRID; 280457; 33.
DR STRING; 284812.Q09866; -.
DR iPTMnet; Q09866; -.
DR MaxQB; Q09866; -.
DR PaxDb; 4896-SPAC12G12-01c-1; -.
DR EnsemblFungi; SPAC12G12.01c.1; SPAC12G12.01c.1:pep; SPAC12G12.01c.
DR PomBase; SPAC12G12.01c; -.
DR VEuPathDB; FungiDB:SPAC12G12.01c; -.
DR eggNOG; KOG1008; Eukaryota.
DR HOGENOM; CLU_005843_0_0_1; -.
DR InParanoid; Q09866; -.
DR OMA; GYMAYKD; -.
DR PhylomeDB; Q09866; -.
DR PRO; PR:Q09866; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0061700; C:GATOR2 complex; IPI:PomBase.
DR GO; GO:0005774; C:vacuolar membrane; EXP:PomBase.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; ISM:PomBase.
DR GO; GO:0008270; F:zinc ion binding; ISM:PomBase.
DR GO; GO:1904263; P:positive regulation of TORC1 signaling; ISO:PomBase.
DR CDD; cd16691; mRING-H2-C3H3C2_Mio; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR037593; MIOS/Sea4.
DR InterPro; IPR049092; MIOS_a-sol.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR031488; Zn_ribbon_mio.
DR PANTHER; PTHR16453:SF9; GATOR COMPLEX PROTEIN MIOS; 1.
DR PANTHER; PTHR16453; WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER; 1.
DR Pfam; PF21719; MIOS_a-sol; 1.
DR Pfam; PF17034; zinc_ribbon_16; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome; Repeat; WD repeat.
FT CHAIN 1..905
FT /note="Uncharacterized WD repeat-containing protein
FT C12G12.01c"
FT /id="PRO_0000051489"
FT REPEAT 42..82
FT /note="WD 1"
FT REPEAT 86..128
FT /note="WD 2"
FT REPEAT 136..175
FT /note="WD 3"
FT REPEAT 177..217
FT /note="WD 4"
FT MOD_RES 394
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
FT MOD_RES 397
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18257517"
SQ SEQUENCE 905 AA; 101948 MW; 56BCF35CA07F709B CRC64;
MLNRSKKRNG CYFWVNGSSD EIRYVAVKAS PKVNWKTHII WRSLKNVKCI DSFHGNNEIL
GAGSSTGNIS LLSVKHPEFQ AVVTPGYARP CNSLAFSETE HLVAGFAKSR NESSLKLWDL
NSLLSDPKSS PLMQSSTLDG VSSVCYKKDT PLLLTGSTSR SVHIIDTRQQ LDSVSSVNTQ
YYSNIVVDPF SPNYFAANSY DGDIAIFDTR YFKSDNYLQI ILRNENKKPK NPQLFALKYS
EWKPGQLAVL SNNSITLRQL LPCVNGNEGS ANNSVFVNYE KKYPVKPNSQ CSGIDFFTPS
TAFPTHVQIL GVINEQPKLF SVHDEVIPFS FNPYNDLIFS FKEKLYPLNS SPFNTLSDVP
QFDVSEFVDE NSFDSSSSCS SKVFLTTRNN SINSEDSAHE VLLSYNRVLG SDIQGTILDR
VKKGYQFDSQ KNSELVSDLY LKDLWSWIHL SHRQSEESLF GDTGDTDFSY QGALGIWFMD
TELTSMSDVF EAKESKFLEK KILRLARDVI ERLDLDIFTS IQTKRPLRQL ALLACGLGMS
NDDLLLEIRR LIRKNEHVKA AGLALFHGKI ENVVRILSSG NELEKTISTA VAGYITSQGL
SNFGSDSLWK EMSRNLSTEL EDPYLRAIFA YVSNSDWRDV LDEVSLSLKD RLGIALRFLP
DDDLSNYLCD LCHTTVQSGD PEGLLLTGLT PLGMELLQNY IDHTSDVQTA ALIAAFVVPK
KFLDKRAEDW TESYRELLNR WKLYRERAKF DIFRTELSKN HTGEITRKAT EPSIRIICNF
CRKPIFPFSN RNECNNLPTP IQRGVSKAGP AKHLGKSCPH CGQPLPKCSV CGFSLGDEDV
PQKDDFSQKP QNYVKEVNLQ KSRFGLWFSF CLNCGHGAHA SHASEWFSTH TICPVPNCDC
ECKLK
//
