ID RCL1_SCHPO Reviewed; 363 AA.
AC Q09870;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 27-MAR-2024, entry version 145.
DE RecName: Full=Probable RNA 3'-terminal phosphate cyclase-like protein;
GN ORFNames=SPAC12G12.06c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Does not have cyclase activity. Plays a role in 40S-
CC ribosomal-subunit biogenesis in the early pre-rRNA processing steps at
CC sites A0, A1 and A2 that are required for proper maturation of the 18S
CC RNA (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RNA 3'-terminal cyclase family. Type 2
CC subfamily. {ECO:0000305}.
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DR EMBL; CU329670; CAA91501.1; -; Genomic_DNA.
DR PIR; S62537; S62537.
DR RefSeq; NP_592892.1; NM_001018292.2.
DR AlphaFoldDB; Q09870; -.
DR SMR; Q09870; -.
DR BioGRID; 279377; 24.
DR STRING; 284812.Q09870; -.
DR MaxQB; Q09870; -.
DR PaxDb; 4896-SPAC12G12-06c-1; -.
DR EnsemblFungi; SPAC12G12.06c.1; SPAC12G12.06c.1:pep; SPAC12G12.06c.
DR GeneID; 2542936; -.
DR KEGG; spo:SPAC12G12.06c; -.
DR PomBase; SPAC12G12.06c; -.
DR VEuPathDB; FungiDB:SPAC12G12.06c; -.
DR eggNOG; KOG3980; Eukaryota.
DR HOGENOM; CLU_027882_1_0_1; -.
DR InParanoid; Q09870; -.
DR OMA; YTDQNKG; -.
DR PhylomeDB; Q09870; -.
DR Reactome; R-SPO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR PRO; PR:Q09870; -.
DR Proteomes; UP000002485; Chromosome I.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0004521; F:RNA endonuclease activity; IBA:GO_Central.
DR GO; GO:0000479; P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR CDD; cd00295; RNA_Cyclase; 1.
DR Gene3D; 3.65.10.20; RNA 3'-terminal phosphate cyclase domain; 1.
DR Gene3D; 3.30.360.20; RNA 3'-terminal phosphate cyclase, insert domain; 1.
DR InterPro; IPR013791; RNA3'-term_phos_cycl_insert.
DR InterPro; IPR023797; RNA3'_phos_cyclase_dom.
DR InterPro; IPR037136; RNA3'_phos_cyclase_dom_sf.
DR InterPro; IPR000228; RNA3'_term_phos_cyc.
DR InterPro; IPR016443; RNA3'_term_phos_cyc_type_2.
DR InterPro; IPR020719; RNA3'_term_phos_cycl-like_CS.
DR InterPro; IPR013792; RNA3'P_cycl/enolpyr_Trfase_a/b.
DR InterPro; IPR036553; RPTC_insert.
DR NCBIfam; TIGR03400; 18S_RNA_Rcl1p; 1.
DR PANTHER; PTHR11096; RNA 3' TERMINAL PHOSPHATE CYCLASE; 1.
DR PANTHER; PTHR11096:SF1; RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN; 1.
DR Pfam; PF01137; RTC; 1.
DR Pfam; PF05189; RTC_insert; 1.
DR SUPFAM; SSF55205; EPT/RTPC-like; 1.
DR PROSITE; PS01287; RTC; 1.
PE 3: Inferred from homology;
KW Nucleus; Reference proteome; Ribosome biogenesis.
FT CHAIN 1..363
FT /note="Probable RNA 3'-terminal phosphate cyclase-like
FT protein"
FT /id="PRO_0000156443"
SQ SEQUENCE 363 AA; 39525 MW; 4FC3AC613E6017BB CRC64;
MSTGQLKRFK GCEYLTHRLV LATLSGTPIR VEGIYPDEAD PGVKDYQVSF LRLLEKLTNG
SVIEISYTGT SFIYRPGNII GGRVVHDCPT TKGIGYFLEP ILILCLFAKT PTSLTLTGVT
SSNEDIGVDV LRTSVLPSLQ KRFQVGDELE LRILKRGSAP GGGGEVNFLC PVIKESLPPI
RLSEFGRVFR IRGIASSTRV SPAFANRLVE SARGVLNPFI PDVFIYTDVR RGDECGNSPG
YSITLVAETN KGCSYAAEHC GEAGETPEDV GSFCAKKLLE VIESGGCVDP YTQPSTLTGM
LLSSEDVNTI VVGQLGITSQ LVVFLRDVKA LFNCEYRFKE LESGQVEMSC LGKGYLNVNR
RIQ
//
