ID   Q0A9M5_ALKEH            Unreviewed;       702 AA.
AC   Q0A9M5;
DT   17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   17-OCT-2006, sequence version 1.
DT   27-MAR-2024, entry version 101.
DE   RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE            EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE   AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN   OrderedLocusNames=Mlg_1110 {ECO:0000313|EMBL:ABI56462.1};
OS   Alkalilimnicola ehrlichii (strain ATCC BAA-1101 / DSM 17681 / MLHE-1).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales;
OC   Ectothiorhodospiraceae; Alkalilimnicola.
OX   NCBI_TaxID=187272 {ECO:0000313|EMBL:ABI56462.1, ECO:0000313|Proteomes:UP000001962};
RN   [1] {ECO:0000313|Proteomes:UP000001962}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-1101 / DSM 17681 / MLHE-1
RC   {ECO:0000313|Proteomes:UP000001962};
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C.,
RA   Glavina del Rio T., Hammon N., Israni S., Dalin E., Tice H., Pitluck S.,
RA   Sims D., Brettin T., Bruce D., Han C., Tapia R., Gilna P., Schmutz J.,
RA   Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N., Oremland R.S.,
RA   Hoeft S.E., Switzer-Blum J., Kulp T., King G., Tabita R., Witte B.,
RA   Santini J.M., Basu P., Hollibaugh J.T., Xie G., Stolz J.F., Richardson P.;
RT   "Complete sequence of Alkalilimnicola ehrilichei MLHE-1.";
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR   EMBL; CP000453; ABI56462.1; -; Genomic_DNA.
DR   RefSeq; WP_011628857.1; NC_008340.1.
DR   AlphaFoldDB; Q0A9M5; -.
DR   KEGG; aeh:Mlg_1110; -.
DR   eggNOG; COG3973; Bacteria.
DR   HOGENOM; CLU_010312_4_0_6; -.
DR   OrthoDB; 7066673at2; -.
DR   Proteomes; UP000001962; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR   InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014016; UvrD-like_ATP-bd.
DR   PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR   PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR   Pfam; PF00580; UvrD-helicase; 1.
DR   Pfam; PF13361; UvrD_C; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE   4: Predicted;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00560};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000001962}.
FT   DOMAIN          207..538
FT                   /note="UvrD-like helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51198"
FT   COILED          16..43
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   BINDING         228..235
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ   SEQUENCE   702 AA;  80826 MW;  E1DED2F2E1076596 CRC64;
     MSTENAPQTP AEQEEHARLA EVMARLQRAL EATDRRLRAY AEEVREQKEY LWEARADMDH
     VEKISTRQSI EQSVMTGETI LDRQKRLKKL QRAPYFGRLD FAADGATGTD PIYIGIHHFY
     DDNSGENVVY DWRAPIASLF YDYETGPARY ESPDGVVDGE VQLKRQFRIR HGKMELMIDS
     NLHVVDEVLQ EELARSSDDS MRNIVATIQR DQNAIIRNET APALIIQGVA GSGKTSIALH
     RIAFLLYRFK ETLSSTDILI ISPNRVFADY IANVLPELGE EQVNEIGMET LADELLESRY
     RFQTFFEQTA ELLENDDEAM KERLRYKASP EFLKKLGEYA AHVEENRFVA EDLWIARRLI
     PGWLLEEIFR KHRNMGMSER IAQVVRETEQ KFGIQYNYDL MPEDRRALRE AVKGMIRQST
     LRETYKQFFT WLGRPELFKT AKRGKLEYAD VFPLIYLKMR LEGIRSPYRY VKHLLIDEMQ
     DYTPVQYAVI ARLFRCNKTI LGDANQSVNP YSASDAEQIQ QAFMQASRVS LTKSYRSSYE
     ITQFAQQIAP NPELEAIERH GEPPRVVRCR TRKAELAHIE EQAMDFQASG HNTLGIICKT
     QRQAKRTHDR LSETLEGIRL LTEQSSGFAP GIIVCTAHMA KGLEFDRVII PEVSEKNYRT
     DMERNLLYVA CTRAMHRLTV THTGAPAAFL PAADEVAVTV SL
//