ID Q0BXW3_HYPNA Unreviewed; 1665 AA.
AC Q0BXW3;
DT 17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 17-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 102.
DE SubName: Full=Alpha-2-macroglobulin family protein {ECO:0000313|EMBL:ABI78781.1};
GN OrderedLocusNames=HNE_3003 {ECO:0000313|EMBL:ABI78781.1};
OS Hyphomonas neptunium (strain ATCC 15444).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomonadales;
OC Hyphomonadaceae; Hyphomonas.
OX NCBI_TaxID=228405 {ECO:0000313|EMBL:ABI78781.1, ECO:0000313|Proteomes:UP000001959};
RN [1] {ECO:0000313|EMBL:ABI78781.1, ECO:0000313|Proteomes:UP000001959}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15444 {ECO:0000313|EMBL:ABI78781.1,
RC ECO:0000313|Proteomes:UP000001959};
RX PubMed=16980487; DOI=10.1128/JB.00111-06;
RA Badger J.H., Hoover T.R., Brun Y.V., Weiner R.M., Laub M.T., Alexandre G.,
RA Mrazek J., Ren Q., Paulsen I.T., Nelson K.E., Khouri H.M., Radune D.,
RA Sosa J., Dodson R.J., Sullivan S.A., Rosovitz M.J., Madupu R.,
RA Brinkac L.M., Durkin A.S., Daugherty S.C., Kothari S.P., Giglio M.G.,
RA Zhou L., Haft D.H., Selengut J.D., Davidsen T.M., Yang Q., Zafar N.,
RA Ward N.L.;
RT "Comparative genomic evidence for a close relationship between the
RT dimorphic prosthecate bacteria Hyphomonas neptunium and Caulobacter
RT crescentus.";
RL J. Bacteriol. 188:6841-6850(2006).
CC -!- SIMILARITY: Belongs to the protease inhibitor I39 (alpha-2-
CC macroglobulin) family. Bacterial alpha-2-macroglobulin subfamily.
CC {ECO:0000256|ARBA:ARBA00010556}.
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DR EMBL; CP000158; ABI78781.1; -; Genomic_DNA.
DR RefSeq; WP_011647977.1; NC_008358.1.
DR STRING; 228405.HNE_3003; -.
DR MEROPS; I39.008; -.
DR KEGG; hne:HNE_3003; -.
DR eggNOG; COG2373; Bacteria.
DR HOGENOM; CLU_000965_1_0_5; -.
DR Proteomes; UP000001959; Chromosome.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR CDD; cd02891; A2M_like; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.60.40.1930; -; 1.
DR InterPro; IPR026284; A2-macglob_dom_prot_bac.
DR InterPro; IPR049120; A2M_bMG2.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR021868; Alpha_2_Macroglob_MG3.
DR InterPro; IPR041203; Bact_A2M_MG5.
DR InterPro; IPR041462; Bact_A2M_MG6.
DR InterPro; IPR041246; Bact_MG10.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR40094; ALPHA-2-MACROGLOBULIN HOMOLOG; 1.
DR PANTHER; PTHR40094:SF1; UBIQUITIN DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF21142; A2M_bMG2; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF17973; bMG10; 1.
DR Pfam; PF11974; bMG3; 1.
DR Pfam; PF17972; bMG5; 1.
DR Pfam; PF17962; bMG6; 1.
DR Pfam; PF01835; MG2; 1.
DR PIRSF; PIRSF038980; A2M_bac; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001959}.
FT DOMAIN 768..911
FT /note="Alpha-2-macroglobulin bait region"
FT /evidence="ECO:0000259|SMART:SM01359"
FT DOMAIN 971..1060
FT /note="Alpha-2-macroglobulin"
FT /evidence="ECO:0000259|SMART:SM01360"
SQ SEQUENCE 1665 AA; 178794 MW; 84B2F37B1BF26DFC CRC64;
MASQVTGPLK GLKAVVFTLL LAGLAACGGS QTRTTADEDA DAAVLVERSP ADQVAARKRE
EARRKAREGE EQDFAYFRYR IDTSTEQPLA CFVFSAALDP QADYAPYVEF RPSFRAALTV
EGRELCVGGL SFGTSRTATI LAGLPAADGR TLKRGETVPI DFADRPAFVG FKGTGVILPR
ENADGLPVET VNVEQVKVTV TRVNDRAIVF KNVSEGQTSA QGQWSWLWGE DSPEDVGEEI
FSGTMDIANT QNAPVITVFP LQDVVGPMKP GAYFVQVEDA AKLTDAEGPP ASSGRWILLT
DLALTAYYGE QGLDVTLRSL KDGKTVSDAT VQLIAANNTV LAETEPDSSG RITFDKPLLN
GKGSMAPRLV VATNAKGELA ALDLNRSPVD LSEYTVGGRR TPGPVDAYVY SDRGIYRPGE
TVELTAMLRD RAGRQVTGRN GHLVIYRPNG LVASKTRFTD PKSGAVLQSF ALPRGASRGE
WRASIEMDGL TAPAGEMRFA VEDFVPQRIA VDVTADQEAP MKAGATRTVD IAARFLYGAP
GAGLTVKTEA RMEPDPKPFK AFDGFIYGRH DQSFEQQILE FDDVTTDGAG KALVRLSPGT
AGSNSGIPLR LNTVVSVLEP GGRAVSESVR VPYRPENLYV GLKPGFDSSV QEGGDASFEV
VAVNADGQAS AQRLSWKVLQ VDYHYDWYRE GETWNWRRSR TVTKVNEGVV TTPAGGVAEI
KVPALEWGSH ELVVEGQGAN ASVGASTGFY VGWGGWESTD GTEAPDRVKV VAAEKTPKAG
QNAELTILPP YDGQAQVVVA TDRVLSVQNL SVSASGTRIT LPVTEEWGEG AYVMVNVYSG
RDPILRAKPR RAVGIAHVPV DMASRTFALT VNAPDLARPR GEQMIEVDIA GGPREPVFLT
VAAVDEGILQ LTKFKSPDPV AHYFGRKALG VELYDDYGRL LDPNLGMPAE VRSGGDQLGG
EGLSVVPVKS VVLYSGLIEA GRSGKAQVRF DIPEFNGELR IMAVAWSKTG VGSADKKMTV
RDRAPADLVM PRFLAPGDEA VITASIDNVE LASGQFSAKV AATGQLNAAD ATLTRTLQKG
QRADIPVRVS ASGEGISSLS LNVTGPDNYR TDRTYEIQSR SPYLPETRAT SQLMRPGETF
SVSQALLAGY VPGSAEVSVG FSPLPIDAPT LYASLDRYPY GCTEQITSRA VPLLYSEQLV
SMGAEESKDD PRNKVQTAVN TVLNRQGADG AFGLWREGDG YANPWLGAYA TDFVFRAKEA
GYAVPDEALT RAYGALRSVA TGDTWRVYGY DTDVYESRYS NDTVQQMMYR SSAYALYVLA
KAGEADISRL RYLHDRELKN IESPLARAHI GAGLAYLGDR ARAASAFKSA EQKLGYRNTG
DYYQTPLRDL AAIVALAAEA QLPEVVARLG ERLGKDVPDA PSLTTQEKAY LLLAVNSLTK
GETAVQVKVE GLGNGQDNER QYSLTEAQAR GGASFRLGGE TPLFRTVLVT GAPSSPPPAV
SSKLSVNKRF LGMDGEPMQL DQIRQGERLL VALTVTPEER RVNPVIVADL LPAGFEIEAI
LRPADGRLVE YDWQSGENRE RAGAFGFLGE IARPQSSQSQ DDRFVAAIDV TENPVTLAYV
VRAVSPGSFA IPGVVAEDMY RPEVFARSAP GRVTVQAVQG AAGGR
//
