ID Q0BZ49_HYPNA Unreviewed; 1137 AA.
AC Q0BZ49;
DT 17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 17-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 120.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN OrderedLocusNames=HNE_2551 {ECO:0000313|EMBL:ABI77789.1};
OS Hyphomonas neptunium (strain ATCC 15444).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomonadales;
OC Hyphomonadaceae; Hyphomonas.
OX NCBI_TaxID=228405 {ECO:0000313|EMBL:ABI77789.1, ECO:0000313|Proteomes:UP000001959};
RN [1] {ECO:0000313|EMBL:ABI77789.1, ECO:0000313|Proteomes:UP000001959}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 15444 {ECO:0000313|EMBL:ABI77789.1,
RC ECO:0000313|Proteomes:UP000001959};
RX PubMed=16980487; DOI=10.1128/JB.00111-06;
RA Badger J.H., Hoover T.R., Brun Y.V., Weiner R.M., Laub M.T., Alexandre G.,
RA Mrazek J., Ren Q., Paulsen I.T., Nelson K.E., Khouri H.M., Radune D.,
RA Sosa J., Dodson R.J., Sullivan S.A., Rosovitz M.J., Madupu R.,
RA Brinkac L.M., Durkin A.S., Daugherty S.C., Kothari S.P., Giglio M.G.,
RA Zhou L., Haft D.H., Selengut J.D., Davidsen T.M., Yang Q., Zafar N.,
RA Ward N.L.;
RT "Comparative genomic evidence for a close relationship between the
RT dimorphic prosthecate bacteria Hyphomonas neptunium and Caulobacter
RT crescentus.";
RL J. Bacteriol. 188:6841-6850(2006).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; CP000158; ABI77789.1; -; Genomic_DNA.
DR RefSeq; WP_011647542.1; NC_008358.1.
DR AlphaFoldDB; Q0BZ49; -.
DR STRING; 228405.HNE_2551; -.
DR KEGG; hne:HNE_2551; -.
DR eggNOG; COG0210; Bacteria.
DR HOGENOM; CLU_008930_0_0_5; -.
DR Proteomes; UP000001959; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF55; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000001959}.
FT DOMAIN 195..494
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 492..775
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT REGION 183..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..208
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 216..223
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 1137 AA; 125346 MW; 69AC16AE3BB1BEB3 CRC64;
MDRIEAIRAR AAVLHDLQVS KGGIRTTPYD FVLGEAGARD LEVRKLPAGH PQLKGGKALL
QRASGTILHE DTGNIFLDAF LVAHEIGHHE FGGAVDIPPT MEIDPARSAD PSSVGADRVV
DYSNRAREEI HMDLFAREFL FPRALAWSWH VDDGLSANDI AKKLGAPYPM VAVQLFDALL
LPPSEPDRDG ESPTKPLNEE QKRAAGHDGK AVLLKAGPGT GKTQTLVGRL SVLKNRGVDP
ESILLLTFSN KAAGEMTDRA IAAWPAAAGS AWIGTFHSFG LDLLRRFHDR AGLPPDPRLI
DATEAIALLE DEFPRLRLKH FNDLWDPTDN LRSILSAISR AKDEVVDQHR YRELAQQMAD
AAETAEEQAA AEKCLEIASV YDLYEQLKSD RGAVDFGDLI ARPTALVESD EAVRVEIQRR
YEHVLVDEYQ DVNRASVRLL RALKPDGSNL WVVGDAKQSI YRFRGASSYN IDRFETEDFP
GGTSLQLSTN YRSSQEICNT FSTFATTRMA ASGFQANAFK GKSGVAPSFV SVESKDHEID
EIAARISAAC DDGTTFRDQA VICKGNARLA EIAAGLEARG IPVLFLGPLF DRPEIKEALS
LLSLVIDPRA MALTCIASMK PFRMFIEDVA VAIEAVRTTK KPLPLDWRTV LETASGMSEG
GRASAKALVG AFEEIEPTAT AWQVFTKIYL DRTRLAADIA TQAREGNANP ALALWQFQNF
LRSVLPEKSG YPIRDLLDHI RRLVILSDER DLRDLPATAQ TINAVRLMTI HGSKGLEFKM
LHLPSLTSDS IPRSAKQSRG LHPPDGMIEG PMFRGSDAID AGHDEEQRCL FFVALSRAKD
GLFLYAPNKK SNGHRQSRSS FVDDISGQLA DQKPISAVRD VVGEAERFTL EVDGVARMSP
SQLATFDKCP RRFFFAHVLQ VGGRRLESAP MRMHNAVQAV IDELTARPDD TPDETEMQSI
IDAAWVAHGP IEHGYASEYR QICDELLKFF ILLRQGECRR PPQTLSLRFE DAEVVVTAHE
QIETSHSTVF RRIRTGRKTS TALDALDAAA FQIAVDGRGE AEFVYLTGGD RDRLTMSEGK
IATRKKKIAN AVISIIEGRF PPNRSDRCAR CPYFFICNPP PSGTLRKKIG SSLPDSS
//
