ID Q0C8F6_ASPTN Unreviewed; 724 AA.
AC Q0C8F6;
DT 17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 17-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=Sorting nexin MVP1 {ECO:0000256|ARBA:ARBA00014268};
GN ORFNames=ATEG_10028 {ECO:0000313|EMBL:EAU29477.1};
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663 {ECO:0000313|EMBL:EAU29477.1, ECO:0000313|Proteomes:UP000007963};
RN [1] {ECO:0000313|Proteomes:UP000007963}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156 {ECO:0000313|Proteomes:UP000007963};
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for vacuolar protein sorting.
CC {ECO:0000256|ARBA:ARBA00002474}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Membrane {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; CH476609; EAU29477.1; -; Genomic_DNA.
DR RefSeq; XP_001209330.1; XM_001209330.1.
DR AlphaFoldDB; Q0C8F6; -.
DR STRING; 341663.Q0C8F6; -.
DR EnsemblFungi; EAU29477; EAU29477; ATEG_10028.
DR GeneID; 4319462; -.
DR VEuPathDB; FungiDB:ATEG_10028; -.
DR eggNOG; KOG2273; Eukaryota.
DR HOGENOM; CLU_009058_1_0_1; -.
DR OMA; SSPWDMP; -.
DR OrthoDB; 45524at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR CDD; cd07597; BAR_SNX8; 1.
DR CDD; cd06866; PX_SNX8_Mvp1p_like; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR028662; SNX8/Mvp1.
DR InterPro; IPR035704; SNX8/Mvp1_PX.
DR InterPro; IPR045734; Snx8_BAR_dom.
DR PANTHER; PTHR47554; SORTING NEXIN MVP1; 1.
DR PANTHER; PTHR47554:SF1; SORTING NEXIN MVP1; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF19566; Snx8_BAR_dom; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000007963};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 351..459
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..239
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..340
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..206
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 724 AA; 79813 MW; 0C05F0D0958AC0B1 CRC64;
MSLFGTSPDD SSSMGNSAQR SKSSLFADDP SLGGNGTGPN YGSSSLFADD DSGSPWNSNP
NKRAARHQLV KTLLADSEVP ESYIDAYDLV LNVGDRVGSG VGLTSVREIL SSSGLTATDQ
AKILNLVVSG DIDNAGGLGR GEFNVLLALV GLAQEGEDLT FDAVDDRRKK LPIPKTSYLD
TLRARQEAPA AERPTTPPPP ATPQQEPPSA QSRRSGRDSM GGLEADPWAS PDLHRGHAHA
QADVPAPIMN GFGSVRSATN AWSGRSGEDT KANDASDGQR TNGQPDAGAS SANAGFGWGE
SFGSSGSGGG LGGPLRAGLG GFGPPSGDNN DPNHPRRRSL GIDRVTSPHV EEVVTVTLLP
EKEGMFMFQH RNYEVKCARR GSTVIRRYSD FVWLLDCLHK RYPFRQLPLL PPKRIAADSN
SFLEKRRRGL VRFTNALVRH PVLSQEQLVI MFLTVPTELS VWRKQATISV QDEFTGKALP
PDLEDSLPST LTDTFETVRS GVRRSAEVYI NLCTLLERLA KRNEGLAADH LRFSLALQSL
TEMTRDTYAM DTNDVPLLNE GIKATARHLS ASQSLLEDEA RAWEEGMLED LKRQRDTLVS
VREMFDRRDR YARNNIPQLE RRIESNERKL QELRQRPTGT MKPGEIEKVE EAIFKDKESI
VQQHARGVLI RECVRDELVY FQQSQYHISR LHQDWSQERV KYSELQADNW RSLSDQVEGM
PLGD
//
