ID Q0C9V9_ASPTN Unreviewed; 1680 AA.
AC Q0C9V9;
DT 17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 17-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 91.
DE RecName: Full=Ras GTPase activating protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=ATEG_09525 {ECO:0000313|EMBL:EAU29716.1};
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663 {ECO:0000313|EMBL:EAU29716.1, ECO:0000313|Proteomes:UP000007963};
RN [1] {ECO:0000313|Proteomes:UP000007963}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156 {ECO:0000313|Proteomes:UP000007963};
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CH476608; EAU29716.1; -; Genomic_DNA.
DR RefSeq; XP_001218147.1; XM_001218146.1.
DR STRING; 341663.Q0C9V9; -.
DR EnsemblFungi; EAU29716; EAU29716; ATEG_09525.
DR GeneID; 4354186; -.
DR VEuPathDB; FungiDB:ATEG_09525; -.
DR eggNOG; KOG2128; Eukaryota.
DR HOGENOM; CLU_000972_1_1_1; -.
DR OMA; KGVLVHW; -.
DR OrthoDB; 12619at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:UniProt.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR CDD; cd21206; CH_IQGAP; 1.
DR CDD; cd05127; RasGAP_IQGAP_like; 1.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR000593; RasGAP_C.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR14149:SF14; PATTERNED EXPRESSION SITE; 1.
DR PANTHER; PTHR14149; RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR Pfam; PF03836; RasGAP_C; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00015; IQ; 9.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF143885; RGC domain-like; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 7.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000007963}.
FT DOMAIN 263..374
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 1044..1260
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..172
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 52..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..170
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1680 AA; 192242 MW; 5E9635EA8015275B CRC64;
MSSASFAPSR TSTVSSTVSI GSTPSIGHRR GKSELNAMVA ESIPGVGAKE LSRSTNAGTT
YESVRRSLRP LSQAPNASPP PTKHSIYRHT RSQTADNPQF WKENRPQTPE PRPLANPEAD
SIKERGLYDA PSPSPTSPYH HPSHTASPLT RSPVKSHHSH SLSNSHPPPL TAALSAPELE
TLKKSSTGHL RTLSKFAQSG ETDEFAIDSP SVVGLLGRRR LKRADSVAGK NGPAVARRTN
ASSWAAGNWM DKQRQFIQAY EYLCHIGEAK EWIEEVIQKQ IPPIVQLEEA LRDGVTLAEV
VQAMYPDRPL RIFRHPKLQY RHSDNIALFF RFLDDVELPE LFRFELIDLY EKKNLPKVIH
CVHALSWLLF KKGLVDFRMG NLVGQLEFEH HELEQTQKGL DKAGVSMPSF SGMAANFGAE
PEPEPEPEES EEDRIHRELY ENEGSISDFQ AQIKGAMLRL KLGNLMNDLW DFEPFLIDLQ
SRLRGDWTRQ IVQYRLDMRS FAVNLQAISR GFLARTRQQG DLQTCEALGD DVLLLQSLIR
GAKARAEIDY VRSRVRKEES GIKRIQAALR GALQRMKVSE QWEETRGAEH DVTNLQALIR
GAFLRQRMGV QYEEIDSAQN DAELLQAAIR GMMARKSITR MGELLAREEP SIVSIQAAAR
ALATRTQQSQ QAAALQKTAD GCRALQAMIR GRAVRANIKS LRESLAQHVP VCISLQSTAR
ANAVRAFLES QRQGLAKESG AILDLQSTAR GLILRRRLEA DSEALQREEL TIIDLQALAR
AAILRIEVGG ILEQLDECDD EVSNLQAHIR AMLIRVEVGQ TLADLAAEED VITDFQSRIR
GHLVRSKFEE RRRYYRENME KVVKAQSFVR GRIQGQAYKS LTSGKNPPVG TVKGFVHLLN
DSEFDFDEEV EFERTRKLVV QQVRQNELAE QYISQLDIKI ALLVKNKITL DEVVKHQKHF
GGHVGSLLPN REISSKDPFD LKALNKTSRR KLEHYQVFFF LLQTQSHYLA RLFKRLRELN
TSEKEYERIR HLMMGLFGYS QKRREEYYLV KLLARSAQEE VQSFDSLHEY LRCNSFWNKL
FASYIKSPRD RKFMRDVLGP LVRENIIDNP DLDLESDPIQ IYRSAINNEE LRTGRRSRRR
PDIPREEAIR DPETRATFIQ NLQELRDIAD QFFTALEEVL YRMPFGIRYI AKSMYESLLS
RFANEDPGFI LQTAGHWVWR NYFQPALMEP EKYGVVDRGM TQEQKRNLGE IAKVVAQVAS
GRLFGAENVY LQPLNAYIGE SIQRLGQIWG NLVSVQDAEE YFDIDEFNDL YAKTKPTLYI
KMSDIFSIHQ LVAGEIHYIC PNPDDILKEI IRDLGNVKSN ESELMSVNSS EINLTLNPKL
AQVEDPEANV KALFMETKRC VLYIIRVQTG ANLMEIMVKP PTEEDEEKWM TLVRDELSAN
NTRRSAYSEA NTLVDIASMS YTELKQTALE NILQLERTGK IRRDNHYQDL LNAIAIDIRT
KHRRRIQRER ELESARMTLT RLNDQASWLE QQLKTYNDYI EQAMITLQNK KGKKRFLMPF
TKQWDHQREL QKSGKVFKFG SYKYSARNLA DKGVLVHWKG YTERQWDRVD LTISSNEVGV
FTIDGSSGPM MVPGANAQVP LDDLLQAQFN NMQFLDFFDG NLRVNVNLFL HLIMRKFYNE
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