GenomeNet

Database: UniProt
Entry: Q0CI35
LinkDB: Q0CI35
Original site: Q0CI35 
ID   MAK5_ASPTN              Reviewed;         774 AA.
AC   Q0CI35;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 2.
DT   31-JUL-2019, entry version 63.
DE   RecName: Full=ATP-dependent RNA helicase mak5;
DE            EC=3.6.4.13;
GN   Name=mak5; ORFNames=ATEG_06649;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K.,
RA   LaButti K., Pushparaj V., DeCaprio D., Crawford M., Koehrsen M.,
RA   Engels R., Montgomery P., Pearson M., Howarth C., Larson L., Luoma S.,
RA   White J., Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C.,
RA   Denning D.W., Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: ATP-binding RNA helicase involved in the biogenesis of
CC       60S ribosomal subunits and is required for the normal formation of
CC       25S and 5.8S rRNAs. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX24/MAK5
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAU33193.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
DR   EMBL; CH476602; EAU33193.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001215827.1; XM_001215827.1.
DR   SMR; Q0CI35; -.
DR   STRING; 33178.CADATEAP00005953; -.
DR   GeneID; 4322181; -.
DR   EuPathDB; FungiDB:ATEG_06649; -.
DR   HOGENOM; HOG000290702; -.
DR   OrthoDB; 973872at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    774       ATP-dependent RNA helicase mak5.
FT                                /FTId=PRO_0000282486.
FT   DOMAIN      233    441       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      493    643       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     246    253       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       202    230       Q motif.
FT   MOTIF       368    371       DEAD box.
SQ   SEQUENCE   774 AA;  85744 MW;  443838E3FDD8BC19 CRC64;
     MGQKRQRDQK GSGFQSKKRK RGANSSNADD KDDGWDGIVG VEDLNWKEVA LPDRLDDAEG
     FFGLEEIEGV DIVRPEGSGE IRFKAKAGKP KKSILKNKTI PQEDKTFDDE WEGFSDGEAA
     QETTTTEPTE EPVQTTNEET EVKEKKEPKK KEAKKEVKKD AKNAKKEPKK KDLPSQKDKD
     IKPGLSFAAL QDAEEDDGVD ISAWESLGLS PEILNSLSKL KFSSPTAVQK SCIPPILDGH
     DVVGKASTGS GKTLAFGIPI LEYYLEKKRR ETKNKDDKKE TSPIALILSP TRELAHQLVK
     HIGEVITHAP GVNARIALLT GGLSVQKQQR LLNGADIVIG TPGRVWEVLS GGQGLISKMK
     EIKYLVVDEA DRLLSEGHFK EAHEILAALD REEINDFPGA EEDESDDEDS KTQRQTLVFS
     ATFHRDLQQK LAGKGKWTGS DLMNKQESME YLLKKLNFRE EKPKFIDVNP VSQMAEGLKE
     GIVECAAMEK DLYLYTLLLY HPKHRTLVFT NSISAVRRLT QFLQALQLPA LALHSSMAQK
     ARLRSVERFS SPTADPSTIL VATDVAARGL DIKGIDFVIH YHAPRTADTY VHRSGRTARA
     GASGKSVIIC APEEMVGVVR LAAKVHANMA NGKRLPLESL ELDRRIVSRV KQRVTLAARI
     CDANIAKEKV SAEDNWLKNA AEELGVDYDS EEFDERQGRG RGRGRGRQQR ERQASSISKA
     ELAGMRAELK QLLSQRVNVG VSERYLTSGR VDIEALLRGE GNASFLGQVD PLGF
//
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