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Database: UniProt
Entry: Q0CMB0
LinkDB: Q0CMB0
Original site: Q0CMB0 
ID   ROK1_ASPTN              Reviewed;         749 AA.
AC   Q0CMB0;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 2.
DT   31-JUL-2019, entry version 61.
DE   RecName: Full=ATP-dependent RNA helicase rok1;
DE            EC=3.6.4.13;
GN   Name=rok1; ORFNames=ATEG_05174;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K.,
RA   LaButti K., Pushparaj V., DeCaprio D., Crawford M., Koehrsen M.,
RA   Engels R., Montgomery P., Pearson M., Howarth C., Larson L., Luoma S.,
RA   White J., Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C.,
RA   Denning D.W., Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: ATP-dependent RNA helicase involved in 40S ribosomal
CC       subunit biogenesis. Required for the processing and cleavage of
CC       35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: Interacts with the U3 snoRNA and is associated with the
CC       90S and 40S pre-ribosomes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX52/ROK1
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAU34243.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
DR   EMBL; CH476600; EAU34243.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001214352.1; XM_001214352.1.
DR   STRING; 33178.CADATEAP00004839; -.
DR   GeneID; 4320809; -.
DR   EuPathDB; FungiDB:ATEG_05174; -.
DR   HOGENOM; HOG000242486; -.
DR   OrthoDB; 400908at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    749       ATP-dependent RNA helicase rok1.
FT                                /FTId=PRO_0000282701.
FT   DOMAIN      241    457       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      497    665       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     254    261       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF       192    224       Q motif.
FT   MOTIF       404    407       DEAD box.
SQ   SEQUENCE   749 AA;  82178 MW;  01A90298CADEEC0C CRC64;
     MDAFKLLTRS TNLKTGRAAA TSAAQTSRLP STGKAANPQL FHNSEADRLL EEKKKHGQKR
     KRGHGADDAG SEDEDAADLD FFSSAKRAST GGAVAGKRHQ EQASADKDGD SGSEDGSEMD
     EVQRRTVLNA HKIKVTDLRD LDQIQSTNAQ TLQTEEPKKK KKKKAKAQQE EPKTLTKKEQ
     KKARRLFPQP LVSFKELRTK YKISRRLAEN IAEQGFTVPT EVQLGTLPLQ LGDSSVQQAS
     KPGETVEPDL LVVAPTGSGK TLSFLIPVIN KIVRHHHEQP DERGIFAVVV APTKELASQI
     VNEGRKLVQG TGVKITLMKK GMQVVERDGD GDSDEKDVLD EDSADSGSDS EDDEQTTDKK
     TKGKAPVTKS DILVTTPLLL VNALSANRTK PLAALPLVRN IVLDEADVLL DPLFREQTLD
     IWRSCTHPEL RASLWSATMG SNVEDLAKST IQERKDLSGT TKSYPLIRLV VGLKDSAIPN
     IQHKLVYAAT EQGKLLGLRQ LLHPTARTAT DVHLRPPFLI FTQTIPRAVA LHSELLYDIP
     PEAGGSSRIA VLHSELSDSQ RSEIMKGFRK GEIWILVTTD LLARGVDFRG INGVVNYDIP
     NSAAVYVHRV GRTGRAGREG GVAVTYYTKE DIPYVKSIAN IIDVSEKLRG AGGEKSVQKW
     LLDSLPDLSK KDKKELKKHG VKARQSNLKS IKDNKEFRQA KISTKSGYER RMENKKKGAI
     AASRNRKSQP QAPSTGADSG DDSWSGLED
//
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