ID Q0CNG2_ASPTN Unreviewed; 1067 AA.
AC Q0CNG2;
DT 17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 17-OCT-2006, sequence version 1.
DT 22-FEB-2023, entry version 66.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN ORFNames=ATEG_04772 {ECO:0000313|EMBL:EAU35219.1};
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663 {ECO:0000313|EMBL:EAU35219.1, ECO:0000313|Proteomes:UP000007963};
RN [1] {ECO:0000313|Proteomes:UP000007963}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156 {ECO:0000313|Proteomes:UP000007963};
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
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DR EMBL; CH476599; EAU35219.1; -; Genomic_DNA.
DR RefSeq; XP_001213950.1; XM_001213950.1.
DR AlphaFoldDB; Q0CNG2; -.
DR STRING; 341663.Q0CNG2; -.
DR EnsemblFungi; EAU35219; EAU35219; ATEG_04772.
DR GeneID; 4319948; -.
DR VEuPathDB; FungiDB:ATEG_04772; -.
DR eggNOG; KOG1967; Eukaryota.
DR HOGENOM; CLU_005943_1_0_1; -.
DR OMA; FSFMPEF; -.
DR OrthoDB; 38995at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000007963};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 40..297
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 545..1003
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
SQ SEQUENCE 1067 AA; 117466 MW; 20FCD41CD79E3AC3 CRC64;
MSALQTFLLV VDHDKQEAKQ IAERVAQDVE SKKASLIDVV QSLGEYINDE DPILRGKAVS
YLTAVIKALP PKFLSRQQIQ VLTTFFCDRI EDGGAISGLD TLQRLDRFNK ELAEDVARAM
FERLQDHQSR SQSQRFQVYQ LLNELMSNHR AALHEMGDDS LVGIVDLMTG EKDPRNLMLV
FSILKVVMVE WDITNHTELL FESVYNYFPI TFRPPPNDPY GITAQDLKDR LQDCIASTGL
FAPHAIPALL DKLDSTSPNV KKDALNALIA CISSYDPNTV STHSITIWDA LKFEILNAQE
EFLSELSLQA LQGIAKRLSE GVNEVSDQLP LAHYLRPITR ECNEQLREPQ QKQAKPAQQI
LSAISSASAV AFVLVVKAVV APLLTIYQEA DGIAKQRALL ETLSVLFESA VKVYGEWTTR
DSEPTVENPL LEFKDQFSDI LGQALMGVIK EEVSFRTSAL KGFLRLSTLR DYFQDNEIGL
FVQYLDEILL KEESVGRGDL KKEAISALAE ISKHKPRLIM DITFPAFVAT LPDADDGTNT
DYMTTLETLA QISIERDIFE TLVRRLLSKL TILLQKDQPG SAAYPRAILM AILYVMNQRK
MDEDPNIDLY HDKIVVALCR SSAASACGLA KNTILNDAAV LDILGRLCNL IVRSLSRPKQ
DEVAKNVYTL FSDDAFSTVP FAESTTADHQ RTMILSTYLL AALPADSTTT IPYTSDSTSM
AALLSDLTKR CTAPSEPATH LSFLRHIALL TNKFLPKSDL ALATDQLDTL LPPDTSATSN
NSIALTTEQI QTIFWLSKAL ILRLAPKTTQ ILTTLLQLLS STDEPTSTTA ARSFGILLGD
DPVLSPANGA TIRLLSKQRV FTTLVPLIAS KIREVNVADS ASANAPADHI KPAHLTALSG
ILRTISPSLV LPELPTLLPL LLQSLDLATA AEDSQAVRAA TLDTLAVLIR DNGGVRIIDE
CGHVQSLVTR LLRTTEYTRS TDGGVVNGTR LRVNALKCLY LLAQTPQSDA PAIAKAGKLS
PLLPVKNQVL RALRMVLDDP KRDVRKAAVD ARAAWLRGVD DAPEDDE
//
