ID   Q0CNG6_ASPTN            Unreviewed;       326 AA.
AC   Q0CNG6;
DT   17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   17-OCT-2006, sequence version 1.
DT   03-MAY-2023, entry version 78.
DE   SubName: Full=Methylenetetrahydrofolate dehydrogenase {ECO:0000313|EMBL:EAU35215.1};
GN   ORFNames=ATEG_04768 {ECO:0000313|EMBL:EAU35215.1};
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663 {ECO:0000313|EMBL:EAU35215.1, ECO:0000313|Proteomes:UP000007963};
RN   [1] {ECO:0000313|Proteomes:UP000007963}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156 {ECO:0000313|Proteomes:UP000007963};
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH476599; EAU35215.1; -; Genomic_DNA.
DR   RefSeq; XP_001213946.1; XM_001213946.1.
DR   AlphaFoldDB; Q0CNG6; -.
DR   STRING; 341663.Q0CNG6; -.
DR   EnsemblFungi; EAU35215; EAU35215; ATEG_04768.
DR   GeneID; 4320546; -.
DR   VEuPathDB; FungiDB:ATEG_04768; -.
DR   eggNOG; KOG0089; Eukaryota.
DR   HOGENOM; CLU_031413_0_0_1; -.
DR   OMA; CKVITAE; -.
DR   OrthoDB; 2232005at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0005829; C:cytosol; IEA:EnsemblFungi.
DR   GO; GO:0004487; F:methylenetetrahydrofolate dehydrogenase (NAD+) activity; IEA:EnsemblFungi.
DR   GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:EnsemblFungi.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0009113; P:purine nucleobase biosynthetic process; IEA:EnsemblFungi.
DR   Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR000672; THF_DH/CycHdrlase.
DR   InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR   InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR   PANTHER; PTHR48099; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED; 1.
DR   PANTHER; PTHR48099:SF3; METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]; 1.
DR   Pfam; PF00763; THF_DHG_CYH; 1.
DR   Pfam; PF02882; THF_DHG_CYH_C; 1.
DR   PRINTS; PR00085; THFDHDRGNASE.
DR   SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563};
KW   Reference proteome {ECO:0000313|Proteomes:UP000007963}.
FT   DOMAIN          18..122
FT                   /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT                   catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00763"
FT   DOMAIN          144..210
FT                   /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT                   NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02882"
SQ   SEQUENCE   326 AA;  36303 MW;  F806AC1A6344CD33 CRC64;
     MASASESTPA SCKVVLSKNV ANGLLAEVKQ GLQTLDKAPH LVGFLANNDP AARMYAEWTE
     KTCQENGFRY SLREVNRDDL EEAILAANVD SDVDGIIVYY PIFNNRQDQY LQQIVDVSKD
     VEGLSHRYIF NMYQNIRFLD PETKRQKCIL PCTPLAIIKI LEYLNIYNTI LPYGNRLFGR
     TICVVNRSEV VGRPLAALLA NDGACVYSVD VTGIQRFTRG EGLKKGRHEI HDLEGKTLKD
     VAPLCDTVIC GVPGDSYKFD TSLLREGANF GPEVKQKASI FVPSIGKVTI VVLLRNLLRL
     IQNRRLDDVK PAEATERPGT LEAQAQ
//