ID Q0CTP6_ASPTN Unreviewed; 1098 AA.
AC Q0CTP6;
DT 17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 17-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Importin N-terminal domain-containing protein {ECO:0000259|PROSITE:PS50166};
GN ORFNames=ATEG_02938 {ECO:0000313|EMBL:EAU36212.1};
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663 {ECO:0000313|EMBL:EAU36212.1, ECO:0000313|Proteomes:UP000007963};
RN [1] {ECO:0000313|Proteomes:UP000007963}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156 {ECO:0000313|Proteomes:UP000007963};
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|ARBA:ARBA00009340}.
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DR EMBL; CH476597; EAU36212.1; -; Genomic_DNA.
DR RefSeq; XP_001212116.1; XM_001212116.1.
DR AlphaFoldDB; Q0CTP6; -.
DR STRING; 341663.Q0CTP6; -.
DR EnsemblFungi; EAU36212; EAU36212; ATEG_02938.
DR GeneID; 4317449; -.
DR VEuPathDB; FungiDB:ATEG_02938; -.
DR eggNOG; KOG2171; Eukaryota.
DR HOGENOM; CLU_003794_0_1_1; -.
DR OMA; PKRFVQE; -.
DR OrthoDB; 24319at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0034399; C:nuclear periphery; IEA:EnsemblFungi.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:EnsemblFungi.
DR GO; GO:0008139; F:nuclear localization sequence binding; IEA:EnsemblFungi.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006406; P:mRNA export from nucleus; IEA:EnsemblFungi.
DR GO; GO:0006606; P:protein import into nucleus; IEA:EnsemblFungi.
DR GO; GO:0007088; P:regulation of mitotic nuclear division; IEA:EnsemblFungi.
DR GO; GO:0060188; P:regulation of protein desumoylation; IEA:EnsemblFungi.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR InterPro; IPR041653; Importin_rep_4.
DR InterPro; IPR040928; Importin_rep_5.
DR InterPro; IPR041389; Importin_rep_6.
DR InterPro; IPR024687; MMS19_C.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR PANTHER; PTHR10527:SF5; IMPORTIN-5 ISOFORM X1; 1.
DR Pfam; PF13513; HEAT_EZ; 1.
DR Pfam; PF18808; Importin_rep_4; 1.
DR Pfam; PF18816; Importin_rep_5; 1.
DR Pfam; PF18829; Importin_rep_6; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000007963};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 30..111
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
SQ SEQUENCE 1098 AA; 121469 MW; 23620C119716ED85 CRC64;
MSLLPPEVHS ALSQLLRALS TPDNAVRAQA EDQLNNDWIQ NRPDVLLMGL AEQIQGAEEV
VTRTFSAVLF RRIATKTRKD PVTNEAKELF STLSGEQRLV IREKLVTCLT SESTTDVRKK
IGDAVAEIAR QYTDNGDQWP ELLGVLFQAS QSPDAGLREA AYRIFSTTPG IIERPHEDAV
TGVFSKGFKD DNIAVRIAAM EAFASFFRSI SKKSQPKFFS LVPDILNVLP PLKESSESDE
LSSAFMALID LAEISPKMFK GMFNNLVKFS ISVIADKDLS DQVRQNALEL MATFADYAPN
MCRKDPEFAR DMVTQCLSLM TDIGVDDDDA AEWNASEDLD LEESDLNHVA GEQCMDRLAN
KLGGQVILPA TFNWIPRMMS SSAWRDRHAA LMAISAISEG CRDLMVGELD QVLALVVPAL
QDPHPRVRYA GCNALGQMST DFAGTMQEKY HQVVLSNIIP VLDSTEPRVQ AHAAAALVNF
CEEAERKILE PYLADLLQHL LQLLRSPKRY VQEQALSTIA TIADSAENAF DQYYDTLMPL
LFNVLKEEQS KEYRLLRAKA MECATLIALA VGKEKMGQDA LNLVQLLGNI QQNIVDADDP
QSQYLLHCWG RMCRVLGPDF VPYLPGVMPP LLTVAAAKAD IQLLDDEDQI DQVEQDEGWE
LVPLKGKIIG IKTSALEDKN TAIELITIYA QILEAAFEPY VLETMEKIAV PGLAFFFHDP
VRVSSAKLIP QLLNSYRKAH GDTSPGFAQM WSKVAEKIIE VLSAEPTVDT LAEMYQCFYE
SLEVVGKNCL TPAHMQAFIA SAKSTLEDYQ VRVKARLEER AEAAGGDGDE EENLDYEYAV
EDDQNLLSDM NKAFHTVFKS QGTSFLPAWE TLLPFYDAFI TSQDPTQRQW ALCIMDDVLE
FCGAESWKYK DHIMQPLAAG LQDQNAANRQ AAAYGVGVAA QKGGQPWSDF VAASIPSLFQ
VTQIPQARTE EHVYATENAS ASIAKILHYN GAKVANAQEI VTNWINTLPI IYDEEAAPYA
YSFIAQLIDQ QNPAVMSNAD KVFGYIVQAL EAETLQGQTA ARVATSAKQL VAATGLNAEQ
ILAGVNPDNQ AAVRSYFQ
//
