GenomeNet

Database: UniProt
Entry: Q0CY48
LinkDB: Q0CY48
Original site: Q0CY48 
ID   DBP9_ASPTN              Reviewed;         619 AA.
AC   Q0CY48;
DT   20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-MAR-2007, sequence version 2.
DT   31-JUL-2019, entry version 62.
DE   RecName: Full=ATP-dependent RNA helicase dbp9;
DE            EC=3.6.4.13;
GN   Name=dbp9; ORFNames=ATEG_01386;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K.,
RA   LaButti K., Pushparaj V., DeCaprio D., Crawford M., Koehrsen M.,
RA   Engels R., Montgomery P., Pearson M., Howarth C., Larson L., Luoma S.,
RA   White J., Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C.,
RA   Denning D.W., Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: ATP-binding RNA helicase involved in the biogenesis of
CC       60S ribosomal subunits and is required for the normal formation of
CC       25S and 5.8S rRNAs. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX56/DBP9
CC       subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAU38143.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
DR   EMBL; CH476595; EAU38143.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_001208751.1; XM_001208751.1.
DR   SMR; Q0CY48; -.
DR   STRING; 33178.CADATEAP00003284; -.
DR   PRIDE; Q0CY48; -.
DR   GeneID; 4315699; -.
DR   EuPathDB; FungiDB:ATEG_01386; -.
DR   HOGENOM; HOG000253015; -.
DR   OrthoDB; 973872at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    619       ATP-dependent RNA helicase dbp9.
FT                                /FTId=PRO_0000281719.
FT   DOMAIN       58    236       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      247    484       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND      71     78       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF        27     55       Q motif.
FT   MOTIF       184    187       DEAD box.
SQ   SEQUENCE   619 AA;  69057 MW;  27422BDAC21BBB15 CRC64;
     MKRKLDANDV PSPEAADDSV KNDVDNLDFE SLNLDPRLRQ ALVKEKFTKP TLVQAKAIPL
     ALEGKDILAR AKTGSGKTAA YVLPILQTIL QKKANDPSLK ATTGLILVPT RELAEQVQNV
     ITTFAAFCGK DVRSVNLTQK VSDAVQRTML ADYPDLIVST PSRVIANLGS SALSLENLTH
     LVIDEADLVL SYGYDEDINA LAKAIPRGVQ TFLMSATLTA EVDTLKGLFC RSPVILKLED
     KDDQGSGVSQ FVVKCAEDEK FLLTYVIFKL QLIKGKVIIF VGDVDRCYRV KLFLEQFGIK
     SCVLNSELPV NSRLHVVQEF NKGVYDIIIA ADEQEVMGAR KSKKSKEAEE NDAGEAAGSS
     DEDEGEAQKP STTRSDKPSE KRRKTAGKDK DYGISRGIDF QNVACVLNFD LPTTSKSYTH
     RIGRTGRAGK TGMALSFVVP ADQFGKHKPT SFPTAKHDET VLAKITKRQA KLGHEVKPYH
     FEMKQVDAFR YRMTDALRSI TRLAVQEARA REIRQELIKS EKLKRHFEEN PEELRQLRHD
     DELRSARIQP HLKHIPDYLM PSKGKKGISS ENVGYVGFRK TSENRIRKAR EKNRGKGKGR
     NYAGVKKVDP LKTFNRGRK
//
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