ID Q0CYX8_ASPTN Unreviewed; 378 AA.
AC Q0CYX8;
DT 17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 17-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=CobW/HypB/UreG nucleotide-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=ATEG_01106 {ECO:0000313|EMBL:EAU37863.1};
OS Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=341663 {ECO:0000313|EMBL:EAU37863.1, ECO:0000313|Proteomes:UP000007963};
RN [1] {ECO:0000313|Proteomes:UP000007963}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NIH 2624 / FGSC A1156 {ECO:0000313|Proteomes:UP000007963};
RA Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA Nierman W.C., Milne T., Madden K.;
RT "Annotation of the Aspergillus terreus NIH2624 genome.";
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:19670;
CC Evidence={ECO:0000256|ARBA:ARBA00001702};
CC -!- SIMILARITY: Belongs to the SIMIBI class G3E GTPase family. ZNG1
CC subfamily. {ECO:0000256|ARBA:ARBA00034320}.
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DR EMBL; CH476595; EAU37863.1; -; Genomic_DNA.
DR RefSeq; XP_001208471.1; XM_001208471.1.
DR AlphaFoldDB; Q0CYX8; -.
DR STRING; 341663.Q0CYX8; -.
DR EnsemblFungi; EAU37863; EAU37863; ATEG_01106.
DR GeneID; 4315688; -.
DR VEuPathDB; FungiDB:ATEG_01106; -.
DR eggNOG; KOG2743; Eukaryota.
DR HOGENOM; CLU_017452_0_1_1; -.
DR OMA; GHSHMDP; -.
DR OrthoDB; 1010489at2759; -.
DR Proteomes; UP000007963; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:EnsemblFungi.
DR GO; GO:0140827; F:zinc chaperone activity; IEA:EnsemblFungi.
DR CDD; cd03112; CobW-like; 1.
DR Gene3D; 3.30.1220.10; CobW-like, C-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR036627; CobW-likC_sf.
DR InterPro; IPR011629; CobW-like_C.
DR InterPro; IPR003495; CobW/HypB/UreG_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13748:SF31; COBW DOMAIN-CONTAINING PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR13748; COBW-RELATED; 1.
DR Pfam; PF02492; cobW; 2.
DR Pfam; PF07683; CobW_C; 1.
DR SUPFAM; SSF90002; Hypothetical protein YjiA, C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000007963}.
FT DOMAIN 43..77
FT /note="CobW/HypB/UreG nucleotide-binding"
FT /evidence="ECO:0000259|Pfam:PF02492"
FT DOMAIN 88..220
FT /note="CobW/HypB/UreG nucleotide-binding"
FT /evidence="ECO:0000259|Pfam:PF02492"
FT DOMAIN 308..372
FT /note="CobW C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07683"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 378 AA; 41447 MW; D824DEB5561941B9 CRC64;
MDLDDEDAPP ELVDVSQLPD SENPNVSITP STSLDTSAQN RVPITLVTGY LGAGKTTLLN
YILNEKHGKK IAVIMNAHLD CRIRRLDSGV MAIESLMERR GTFDYILLET TGLADPGNIA
PIFWVDDNLG SSIYLDGIVT LVDAKNILHL LDEPTPEETV SAHEKDDEHA HEHTGPVLSM
AHMQISHADV IILNKVDLVT PEELETVRQR IAAINTVAKI HVTDHSKTPQ IEGVVLDLHA
YEHLASLDFG EKGHSHIDPA ISTIAITTPP IASDKVSRVD SWLQSVLWDS TLPSAGPSVP
DSHPTDFDIH RLKGILVTED GSEKIIQAVR DVFEIRDSES APAAERKMQC KIVLIGRGLG
PDAQPWQRSL EAFLERAD
//
