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Database: UniProt
Entry: Q0CZS8
LinkDB: Q0CZS8
Original site: Q0CZS8 
ID   HAS1_ASPTN              Reviewed;         576 AA.
AC   Q0CZS8;
DT   03-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   16-OCT-2019, entry version 71.
DE   RecName: Full=ATP-dependent RNA helicase has1;
DE            EC=3.6.4.13;
GN   Name=has1; ORFNames=ATEG_00806;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K.,
RA   LaButti K., Pushparaj V., DeCaprio D., Crawford M., Koehrsen M.,
RA   Engels R., Montgomery P., Pearson M., Howarth C., Larson L., Luoma S.,
RA   White J., Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C.,
RA   Denning D.W., Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: ATP-dependent RNA helicase involved in 40S ribosomal
CC       subunit biogenesis. Required for the processing and cleavage of
CC       35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC   -!- SUBUNIT: Associates in the nucleolus with the 60S and pre-60S
CC       ribosomal subunits. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- DOMAIN: The Q motif is unique to and characteristic of the DEAD
CC       box family of RNA helicases and controls ATP binding and
CC       hydrolysis.
CC   -!- SIMILARITY: Belongs to the DEAD box helicase family. DDX18/HAS1
CC       subfamily. {ECO:0000305}.
DR   EMBL; CH476594; EAU39452.1; -; Genomic_DNA.
DR   RefSeq; XP_001210892.1; XM_001210892.1.
DR   SMR; Q0CZS8; -.
DR   STRING; 33178.CADATEAP00008421; -.
DR   EnsemblFungi; EAU39452; EAU39452; ATEG_00806.
DR   GeneID; 4355567; -.
DR   EuPathDB; FungiDB:ATEG_00806; -.
DR   HOGENOM; HOG000268799; -.
DR   OMA; AHHSQTY; -.
DR   OrthoDB; 973872at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR   InterPro; IPR025313; DUF4217.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000629; RNA-helicase_DEAD-box_CS.
DR   InterPro; IPR014014; RNA_helicase_DEAD_Q_motif.
DR   Pfam; PF00270; DEAD; 1.
DR   Pfam; PF13959; DUF4217; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM01178; DUF4217; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS00039; DEAD_ATP_HELICASE; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS51195; Q_MOTIF; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Complete proteome; Helicase; Hydrolase;
KW   Nucleotide-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   RNA-binding; rRNA processing.
FT   CHAIN         1    576       ATP-dependent RNA helicase has1.
FT                                /FTId=PRO_0000282470.
FT   DOMAIN      129    305       Helicase ATP-binding.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00541}.
FT   DOMAIN      319    490       Helicase C-terminal.
FT                                {ECO:0000255|PROSITE-ProRule:PRU00542}.
FT   NP_BIND     142    149       ATP. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00541}.
FT   MOTIF        98    126       Q motif.
FT   MOTIF       252    255       DEAD box.
SQ   SEQUENCE   576 AA;  64310 MW;  0FC6E9B591741045 CRC64;
     MGSAQDQTKK RKRQKVSDGS KSSKSRVVEA DDQRELTETT TKPKKQKTED PPTDETPDAE
     DVEQTENGET AQDDAAKDAE APLPSTMGLS LPTDAAPQKF DELNLSEPTM KAIRQMGFET
     MTEIQQRTIP PTLAGRDILG AAKTGSGKTL AFLIPAVEML SALRFKPRNG TGVIIITPTR
     ELALQIFGVA KELCEFHSQT YGIVIGGANR RAEAEKLNKG VNLLIATPGR LLDHLQNTQG
     FVYKNCKVLV LDEADRCLDV GFEAELRQIV KILPSEERQT LLFSATQTTK VEDLARISLK
     PGPLYINVDH RKEHATVDGV DQGYIICEAD KRFLLLFTFL KKNLKKKIII FFSSCNAVKY
     YADLLNYIDL PVLALHGKLK QQTRTQRFFE FCNATQGTLI CTDVAARGLD IPAVDYIIQF
     DPPDEPKAYI HRVGRTARGT KGKIGRSIML LQPSEVGFLN VLREARVPVV EFEFPQKKII
     DIQSQLEKLI GQNYYLNQIQ SAKDGYRAYL HAYASHSLRS VFNINKLDLV KVAKSFGFTT
     PPRVDITLGA SMSKDKVQAR RPYGSQNKSA RFKRRA
//
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