ID Q0E9N2_DROME Unreviewed; 1746 AA.
AC Q0E9N2;
DT 17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 01-APR-2015, sequence version 3.
DT 24-JAN-2024, entry version 122.
DE SubName: Full=Lethal (2) 01289, isoform K {ECO:0000313|EMBL:ABI31026.3};
GN Name=hlk {ECO:0000313|FlyBase:FBgn0010482};
GN Synonyms=CG30444 {ECO:0000313|EMBL:ABI31026.3}, CG9435
GN {ECO:0000313|EMBL:ABI31026.3}, Dmel\CG9432
GN {ECO:0000313|EMBL:ABI31026.3}, l(2)01289
GN {ECO:0000313|EMBL:ABI31026.3};
GN ORFNames=CG9432 {ECO:0000313|EMBL:ABI31026.3,
GN ECO:0000313|FlyBase:FBgn0010482}, Dmel_CG9432
GN {ECO:0000313|EMBL:ABI31026.3};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227 {ECO:0000313|EMBL:ABI31026.3, ECO:0000313|Proteomes:UP000000803};
RN [1] {ECO:0000313|EMBL:ABI31026.3, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A.,
RA An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E.,
RA Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C.,
RA Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A.,
RA Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C.,
RA Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G.,
RA Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.,
RA Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000313|EMBL:ABI31026.3, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537568;
RA Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT "Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster
RT euchromatic genome sequence.";
RL Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN [3] {ECO:0000313|EMBL:ABI31026.3, ECO:0000313|Proteomes:UP000000803}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000313|EMBL:ABI31026.3, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537573;
RA Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M., Ashburner M.,
RA Celniker S.E.;
RT "The transposable elements of the Drosophila melanogaster euchromatin: a
RT genomics perspective.";
RL Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN [5] {ECO:0000313|EMBL:ABI31026.3, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=12537574;
RA Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA Karpen G.H.;
RT "Heterochromatic sequences in a Drosophila whole-genome shotgun assembly.";
RL Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN [6] {ECO:0000313|EMBL:ABI31026.3, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA Ashburner M., Anxolabehere D.;
RT "Combined evidence annotation of transposable elements in genome
RT sequences.";
RL PLoS Comput. Biol. 1:166-175(2005).
RN [7] {ECO:0000313|EMBL:ABI31026.3, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569856; DOI=10.1126/science.1139815;
RA Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT "The Release 5.1 annotation of Drosophila melanogaster heterochromatin.";
RL Science 316:1586-1591(2007).
RN [8] {ECO:0000313|EMBL:ABI31026.3, ECO:0000313|Proteomes:UP000000803}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX PubMed=17569867; DOI=10.1126/science.1139816;
RA Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA Dimitri P., Karpen G.H., Celniker S.E.;
RT "Sequence finishing and mapping of Drosophila melanogaster
RT heterochromatin.";
RL Science 316:1625-1628(2007).
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DR EMBL; AE013599; ABI31026.3; -; Genomic_DNA.
DR RefSeq; NP_001036475.3; NM_001043010.4.
DR SMR; Q0E9N2; -.
DR EnsemblMetazoa; FBtr0308840; FBpp0300997; FBgn0010482.
DR GeneID; 46017; -.
DR UCSC; CG9432-RD; d. melanogaster.
DR AGR; FB:FBgn0010482; -.
DR CTD; 46017; -.
DR FlyBase; FBgn0010482; hlk.
DR VEuPathDB; VectorBase:FBgn0010482; -.
DR GeneTree; ENSGT00530000065177; -.
DR OrthoDB; 3043426at2759; -.
DR BioGRID-ORCS; 46017; 0 hits in 1 CRISPR screen.
DR ChiTaRS; l(2)01289; fly.
DR GenomeRNAi; 46017; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0010482; Expressed in crop (Drosophila) and 19 other cell types or tissues.
DR ExpressionAtlas; Q0E9N2; baseline and differential.
DR Genevisible; Q0E9N2; DM.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd02961; PDI_a_family; 5.
DR Gene3D; 3.40.50.11390; -; 1.
DR Gene3D; 3.40.30.10; Glutaredoxin; 14.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR19991; L 2 01289; 1.
DR PANTHER; PTHR19991:SF3; LETHAL (2) 01289, ISOFORM F; 1.
DR Pfam; PF00085; Thioredoxin; 2.
DR Pfam; PF13848; Thioredoxin_6; 1.
DR SUPFAM; SSF52833; Thioredoxin-like; 12.
DR PROSITE; PS51352; THIOREDOXIN_2; 4.
PE 1: Evidence at protein level;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteomics identification {ECO:0007829|PeptideAtlas:Q0E9N2};
KW Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..1746
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004171269"
FT TRANSMEM 1709..1729
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 38..170
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT DOMAIN 646..809
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT DOMAIN 1213..1326
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
FT DOMAIN 1466..1614
FT /note="Thioredoxin"
FT /evidence="ECO:0000259|PROSITE:PS51352"
SQ SEQUENCE 1746 AA; 201539 MW; BFD3635C6AC7CEA1 CRC64;
MTFTRLKTLS LLVCALLALS FPGHVSGAGN NNNKKGSQPV APPEPEAVIE EVNAKQLEKL
LADKDYVAVF WYARSCVTCD KVLAELEKID DDTDSFGVDF VKINDKRLAK QYGIKNFPAL
TYFREKEPII YDGDLMDEEG VLDFLTSLEA MDLPDRIEEV NAKILQKIIE DTDFVAVLFY
KQQCRKCAKA LQELENIDDE ADQLGIGFVK IHDEALADEY NLGNLPALVY YRHQTPIIYE
GELQREEDVL EWLVQNKSTG DEDDVIEDVT SKTLSTLISN IDNLVVLFYD HGNDDSMTVL
EELEQIDDDC DKHGIQFVKI DDAKAAADYG IDSIPAIVYF EKEIPNVYDG DLMDEEQILK
WLLGQLERDE IEDVTDEMLD TMIKEGRVIA VLFYDNNDKK SQKVLEELEN IDDECDALGI
TFVKIDNPEE AVEYGINKVP KLIYFEKGIP TIYEGNLEDE EKLLKWLTDQ TSSDQIEDIT
DEMLDLIIEK MPHVAVLFYD KDQKKSQKIL AELENIDDEC DQNDIAFVKI DDDKEAKEWG
IDEIPSIVLF ERGIPHIYEG DLMKEDELLG WLVHQKRYSE IPEVTDEMKD KLVENTEHLA
VIFYDKDDKQ DMRILNELEN IDDELEKEGI VIVRIDNAAE AKEYGLDHLP ALIYFENKIP
ALYEGDLMNE DEVLEWLLVQ KKTATIEEVT DEILVTLINE HEYVVVFFTG PCEPGETCEH
TLNALESIDD ELDEAGIIFV TTEDTGIAKK YNVKTYPRLV FFRNRDPLHF TGDLDDEDEV
LAWITDDETL EIPGKIEEVN VKMLDKILAE NDHVVVFFYA EGDKKAQKIL NELENIDDEC
EEKDIDFVKT SDDDIDKEYD LPGLPALAFY RHKFRTIYTG DLMKEEEILE WVIDLHESTA
DVIESVDRKT LQVLINDVEH LAVFFYDDEC ESCSDILEEL ENIDDDTDKH GIQFVKSNDV
KLAHEIGIFA FPALVYYETG VPIMYDGNIA SNQDVFNWIL EQKADQSIQL INRDQLFEYI
GTKDFLAVVF YKEDDPDSPR VLRHIELIDD EAAEYGIYIV KMHDKLMAKK YGFRNPPGLT
YFRKGKYINY DGDIDDEEEV LDWLTSPANM EMTDHIEQVN RKMFEKIRKN SDYVAVIFYS
DECKQCPRVL AEVEHIDDEA DKAGIDFVKI DDKQMAKEYG VFALPAIVFF KPTSKEPVIY
AGDLYEEEQI LTWLITQKDP SGDVIEDLEG ERLVHLIEES GSIAVYFYAD GCEQCTKVLE
ELENIDDDCD KHGITFVKTR DFSVADGYGV HEYPALVYFE GGIPNVFEGE LSEEEEVLQW
LITQKTEDRI ELITRQMLET MVEETQYLAV YFLPPERNGK QPAFCRSFCS PSSLKESNLT
TTKSTKHSSS QFVQNYISRK RKRIEKQDKI NCNICDQILE GLELIDDECD VFGIHMVKIQ
DPQLAKRYSI KTFPALVYFR NGNPLLFEGD LQNEQSVLEW LIDDDNRELA DEIEEVNERM
LDRLMAESTL LVVFFYDDDC AECEEILEEL EEIDGEADMF GIDFVKIASI QAAKKYEIVN
IPSLVYFRKQ VPVLYDGDLH QHDKVITWLT SQDVFEIKNE IEEVNRKMLD KLLEENEFLA
VFFYEHNQPD STAALEKLEN IDSETDNLDI TFVKMADSRY AKKWGVTKLP AMVYFRRRFP
SIYRGDLLSE DEVLEWLRKN RFRQPELNIF MYALIALAVA FVVYTAFLLQ CFKPAPPPPV
QHPKQS
//
