ID Q0FAC3_9RHOB Unreviewed; 777 AA.
AC Q0FAC3;
DT 17-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 17-OCT-2006, sequence version 1.
DT 24-JAN-2024, entry version 87.
DE SubName: Full=3-hydroxyacyl-CoA dehydrogenase {ECO:0000313|EMBL:EAU51036.1};
GN ORFNames=OM2255_07705 {ECO:0000313|EMBL:EAU51036.1};
OS Rhodobacterales bacterium HTCC2255.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales.
OX NCBI_TaxID=367336 {ECO:0000313|EMBL:EAU51036.1, ECO:0000313|Proteomes:UP000009381};
RN [1] {ECO:0000313|EMBL:EAU51036.1, ECO:0000313|Proteomes:UP000009381}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HTCC2255 {ECO:0000313|EMBL:EAU51036.1,
RC ECO:0000313|Proteomes:UP000009381};
RA Giovannoni S., Cho J.-C., Ferriera S., Johnson J., Kravitz S., Halpern A.,
RA Remington K., Beeson K., Tran B., Rogers Y.-H., Friedman R., Venter J.C.;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) +
CC NADH; Xref=Rhea:RHEA:22432, ChEBI:CHEBI:15378, ChEBI:CHEBI:57318,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945, ChEBI:CHEBI:90726; EC=1.1.1.35;
CC Evidence={ECO:0000256|ARBA:ARBA00023693};
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EAU51036.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AATR01000007; EAU51036.1; -; Genomic_DNA.
DR AlphaFoldDB; Q0FAC3; -.
DR eggNOG; COG1024; Bacteria.
DR eggNOG; COG1250; Bacteria.
DR HOGENOM; CLU_010448_0_0_5; -.
DR OrthoDB; 5389341at2; -.
DR BioCyc; RBAC367336:G1GNW-977-MONOMER; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000009381; Unassembled WGS sequence.
DR GO; GO:0003857; F:3-hydroxyacyl-CoA dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR CDD; cd06558; crotonase-like; 1.
DR Gene3D; 1.10.1040.50; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006176; 3-OHacyl-CoA_DH_NAD-bd.
DR InterPro; IPR006108; 3HC_DH_C.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR001753; Enoyl-CoA_hydra/iso.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR48075; 3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN; 1.
DR PANTHER; PTHR48075:SF7; 3-HYDROXYACYL-COA DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00725; 3HCDH; 2.
DR Pfam; PF02737; 3HCDH_N; 1.
DR Pfam; PF00378; ECH_1; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 2.
DR SUPFAM; SSF52096; ClpP/crotonase; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000009381}.
FT DOMAIN 6..188
FT /note="3-hydroxyacyl-CoA dehydrogenase NAD binding"
FT /evidence="ECO:0000259|Pfam:PF02737"
FT DOMAIN 190..295
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
FT DOMAIN 351..406
FT /note="3-hydroxyacyl-CoA dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00725"
SQ SEQUENCE 777 AA; 85574 MW; 39555530C39B1B6C CRC64;
MPEFKQIAVI GAGTMGSGIA AQIANSGNKV LLMDLPRDDD PIGVLKDAKK RLLKSDPPAL
VHKSRIDLIE VGNIRDDFDK LANCDWIVEA IVERLDIKKE LYKRLNEVIN PNCVVTSNTS
TIPISLLVED MPEDFQKRFA ITHYFNPVRY MRLLELVRGA NTDEKIMDQL ADYNDRVMGK
GVVRCNDTPG FLGNRVGVFA LQVGMDEASK NKLTVEEADA LMGRPMGIPK TGVFGLYDLI
GIDLMSDVVN TLGDILPEDD LFHEVGTLNN PVMPLIRDMI QNGFTGDKGK GGFYRIESKT
NCAVDLTNGK IRLRQKTLPI SAQKAADAQA AGDETLVVMI NGSDNHATFC KRFLARTLAY
AADLIPAVTS SPQDIDDAMK LGFNWVRGPF ELIDALGANV VVKLIKEAGL TVPKAISLSE
EIGPFYTVSK SSLNVLNFEN NTFYSPVILP ENTIRFHMTK QSMTPLLTNS AASLYELKGN
LRLLEFHSKA NALTAESMEI VLAAAKNHGD GIIIHNDAQH FSAGVDLNRF RSLIEASNWN
GIDEFLNSFQ QSVKALKYSP VPVIGAPSGL SIGGGFEVLA HCDKLIAHTN TVFGLVETGV
GVVPGGGGVK ETLLRWYQAT GDWEKASWNT WMQIGYGQIG TSPDLSARMQ YYLKDRDVEV
LNRDKLMHVA STEMAKLQKE YLPPIEPVFE LPGSAMIKKM SDFMQNGIHE GLFFPHDKTV
AMQVAEIVVN SADENSITVS EQDMYDRERR AFLNLAKTPE TIVRISSLLD TGEAIRN
//
