ID   Q0K041_CUPNH            Unreviewed;       551 AA.
AC   Q0K041;
DT   03-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2006, sequence version 1.
DT   27-MAR-2024, entry version 102.
DE   SubName: Full=Glucose-methanol-choline oxidoreductase {ECO:0000313|EMBL:CAJ96633.1};
GN   OrderedLocusNames=H16_B1851 {ECO:0000313|EMBL:CAJ96633.1};
OS   Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS   / H16 / Stanier 337) (Ralstonia eutropha).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=381666 {ECO:0000313|EMBL:CAJ96633.1, ECO:0000313|Proteomes:UP000008210};
RN   [1] {ECO:0000313|EMBL:CAJ96633.1, ECO:0000313|Proteomes:UP000008210}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier
RC   337 {ECO:0000313|Proteomes:UP000008210};
RX   PubMed=16964242; DOI=10.1038/nbt1244;
RA   Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA   Eitinger T., Ewering C., Potter M., Schwartz E., Strittmatter A., Voss I.,
RA   Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT   "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT   eutropha H16.";
RL   Nat. Biotechnol. 24:1257-1262(2006).
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|ARBA:ARBA00001974};
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC       {ECO:0000256|ARBA:ARBA00010790, ECO:0000256|RuleBase:RU003968}.
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DR   EMBL; AM260480; CAJ96633.1; -; Genomic_DNA.
DR   RefSeq; WP_010810328.1; NZ_CP039288.1.
DR   AlphaFoldDB; Q0K041; -.
DR   STRING; 381666.H16_B1851; -.
DR   GeneID; 57647753; -.
DR   KEGG; reh:H16_B1851; -.
DR   eggNOG; COG2303; Bacteria.
DR   HOGENOM; CLU_002865_7_1_4; -.
DR   OrthoDB; 9785276at2; -.
DR   Proteomes; UP000008210; Chromosome 2.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR   Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR   Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   PANTHER; PTHR11552:SF147; CHOLINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 1.
DR   PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR   SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR   PROSITE; PS00623; GMC_OXRED_1; 1.
DR   PROSITE; PS00624; GMC_OXRED_2; 1.
PE   3: Inferred from homology;
KW   FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|RuleBase:RU003968};
KW   Flavoprotein {ECO:0000256|ARBA:ARBA00022630,
KW   ECO:0000256|RuleBase:RU003968};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008210}.
FT   DOMAIN          82..105
FT                   /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS00623"
FT   DOMAIN          254..268
FT                   /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS00624"
SQ   SEQUENCE   551 AA;  60595 MW;  18E3F2C4E88DC575 CRC64;
     MSQTVDYIVV GAGSAGCVLA NRLSEDGRYS VCLLEAGPPD RYPWIHIPIG YGKTMFHKQV
     NWGFYTDPDP NMLDRRIYWP RGRTLGGSSA INGLIYVRGQ REDYDHWETL GNPGWSWDNC
     LPYFRKLENN DLGAGPTRGT DGPLNATSID RQHPLVDAFI GAGQALGLPR KTDFNGGDQE
     GVGYYQLTTR NGWRCSTAVA YLRPARGRTN LRVETDAHTT GILFEGKRAV GVRYTQHGQP
     YILRARREVI LCAGALQSPQ LLQLSGIGPA PLLQDLGVPV VHALPGVGEN LQDHLQVRLI
     YEVAKPITTN DQLRSLTGKA RMGLEWLLMR KGPLAIGINQ GAMFCRALPQ ESATPDTQFH
     FSTLSADMAG GTVHPFSGCT YSVCQLRPES RGTVRIRSTD PYEPPSMQPN YLSAELDRRC
     TVAAVRYARR VAQAEPMRGL MKREFRPGDE VRSDDEILHF CREYGATIFH PSGTAKMGPA
     ADPLAVVDAR LRVHGVGGLR VVDCSVMPTL VSGNTNVPVV MMAERAADFI REDARREVHP
     VDVATKMAAA A
//