ID Q0K1G6_CUPNH Unreviewed; 402 AA.
AC Q0K1G6;
DT 03-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:CAJ96158.1};
DE EC=2.3.1.9 {ECO:0000313|EMBL:CAJ96158.1};
GN OrderedLocusNames=H16_B1369 {ECO:0000313|EMBL:CAJ96158.1};
OS Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS / H16 / Stanier 337) (Ralstonia eutropha).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=381666 {ECO:0000313|EMBL:CAJ96158.1, ECO:0000313|Proteomes:UP000008210};
RN [1] {ECO:0000313|EMBL:CAJ96158.1, ECO:0000313|Proteomes:UP000008210}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier
RC 337 {ECO:0000313|Proteomes:UP000008210};
RX PubMed=16964242; DOI=10.1038/nbt1244;
RA Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA Eitinger T., Ewering C., Potter M., Schwartz E., Strittmatter A., Voss I.,
RA Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT eutropha H16.";
RL Nat. Biotechnol. 24:1257-1262(2006).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR EMBL; AM260480; CAJ96158.1; -; Genomic_DNA.
DR RefSeq; WP_011617187.1; NZ_CP039288.1.
DR AlphaFoldDB; Q0K1G6; -.
DR STRING; 381666.H16_B1369; -.
DR GeneID; 57647268; -.
DR KEGG; reh:H16_B1369; -.
DR eggNOG; COG0183; Bacteria.
DR HOGENOM; CLU_031026_2_2_4; -.
DR OrthoDB; 8951704at2; -.
DR Proteomes; UP000008210; Chromosome 2.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR18919:SF153; TRIFUNCTIONAL ENZYME SUBUNIT BETA, MITOCHONDRIAL; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:CAJ96158.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008210};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:CAJ96158.1}.
FT DOMAIN 5..267
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 274..401
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 88
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 358
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 388
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 402 AA; 43081 MW; 528806FD444DE2A3 CRC64;
MRRAAIVTPL RTPVGTFGGS LRPVPVEELA ATAVRAVVER SGIDPARIDD VVFAQSYANS
EVPCVGRWAA LQAGLPVEVP GMQLDRRCGG GLQAIVTASM MVQSGAADVV IAGGVESMSN
IEYYTTDMRW GARSGNVRFF DRLDRGRERS QPVERFGKIS GMIETAENLA RDYGISREAA
DVFAARSHAR AAAAWEAGRF DAEVVPVQVP QRKGDPVRFA RDEGFRPETT RESLGKLRTL
MPNGTVTAGN ASQQNDASAA CLIVAEDKLA ELCLTPMASL VGWAAAGCEP SHMGIGPVPA
VKKLLARLNL TLDQMDLVEL NEAFACQVLA VLKGWEWHDQ DAIEQKLNVN GSGISLGHPI
GATGVRILAT LLHELQRRGG RYGLETMCIG GGQGIAAVFE RY
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