ID   Q0KAC1_CUPNH            Unreviewed;       692 AA.
AC   Q0KAC1;
DT   03-OCT-2006, integrated into UniProtKB/TrEMBL.
DT   03-OCT-2006, sequence version 1.
DT   27-MAR-2024, entry version 95.
DE   RecName: Full=methylmalonyl-CoA mutase {ECO:0000256|ARBA:ARBA00012398};
DE            EC=5.4.99.2 {ECO:0000256|ARBA:ARBA00012398};
GN   Name=sbm2 {ECO:0000313|EMBL:CAJ93050.1};
GN   OrderedLocusNames=H16_A1949 {ECO:0000313|EMBL:CAJ93050.1};
OS   Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS   / H16 / Stanier 337) (Ralstonia eutropha).
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=381666 {ECO:0000313|EMBL:CAJ93050.1, ECO:0000313|Proteomes:UP000008210};
RN   [1] {ECO:0000313|EMBL:CAJ93050.1, ECO:0000313|Proteomes:UP000008210}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier
RC   337 {ECO:0000313|Proteomes:UP000008210};
RX   PubMed=16964242; DOI=10.1038/nbt1244;
RA   Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA   Eitinger T., Ewering C., Potter M., Schwartz E., Strittmatter A., Voss I.,
RA   Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT   "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT   eutropha H16.";
RL   Nat. Biotechnol. 24:1257-1262(2006).
CC   -!- COFACTOR:
CC       Name=adenosylcob(III)alamin; Xref=ChEBI:CHEBI:18408;
CC         Evidence={ECO:0000256|ARBA:ARBA00001922};
CC   -!- SIMILARITY: Belongs to the methylmalonyl-CoA mutase family.
CC       {ECO:0000256|ARBA:ARBA00008465}.
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DR   EMBL; AM260479; CAJ93050.1; -; Genomic_DNA.
DR   RefSeq; WP_011615419.1; NZ_CP039287.1.
DR   AlphaFoldDB; Q0KAC1; -.
DR   STRING; 381666.H16_A1949; -.
DR   GeneID; 57644067; -.
DR   KEGG; reh:H16_A1949; -.
DR   PATRIC; fig|381666.6.peg.2356; -.
DR   eggNOG; COG1884; Bacteria.
DR   eggNOG; COG2185; Bacteria.
DR   HOGENOM; CLU_009523_3_1_4; -.
DR   OrthoDB; 9762378at2; -.
DR   Proteomes; UP000008210; Chromosome 1.
DR   GO; GO:0031419; F:cobalamin binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR   GO; GO:0004494; F:methylmalonyl-CoA mutase activity; IEA:UniProtKB-EC.
DR   Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR   Gene3D; 3.20.20.240; Methylmalonyl-CoA mutase; 1.
DR   InterPro; IPR006159; Acid_CoA_mut_C.
DR   InterPro; IPR016176; Cbl-dep_enz_cat.
DR   InterPro; IPR006158; Cobalamin-bd.
DR   InterPro; IPR036724; Cobalamin-bd_sf.
DR   InterPro; IPR006099; MeMalonylCoA_mutase_a/b_cat.
DR   InterPro; IPR006098; MMCoA_mutase_a_cat.
DR   NCBIfam; TIGR00640; acid_CoA_mut_C; 1.
DR   NCBIfam; TIGR00641; acid_CoA_mut_N; 1.
DR   PANTHER; PTHR48101:SF4; METHYLMALONYL-COA MUTASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR48101; METHYLMALONYL-COA MUTASE, MITOCHONDRIAL-RELATED; 1.
DR   Pfam; PF02310; B12-binding; 1.
DR   Pfam; PF01642; MM_CoA_mutase; 1.
DR   SUPFAM; SSF52242; Cobalamin (vitamin B12)-binding domain; 1.
DR   SUPFAM; SSF51703; Cobalamin (vitamin B12)-dependent enzymes; 1.
DR   PROSITE; PS51332; B12_BINDING; 1.
PE   3: Inferred from homology;
KW   Cobalamin {ECO:0000256|ARBA:ARBA00022628};
KW   Cobalt {ECO:0000256|ARBA:ARBA00023285};
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:CAJ93050.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008210}.
FT   DOMAIN          560..691
FT                   /note="B12-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51332"
SQ   SEQUENCE   692 AA;  74262 MW;  8F8858ABE174442E CRC64;
     MNAKRDDPAG ALELKPVYGS GDLTGLGHLG GMPGEAPFVR GPYPSMYRGR PWTIRQYGGY
     GDAVTSNLAY REALKQGAQG LSVAFDLPTH RGYDSDDPLA QADVGMAGVA IDSVDDMRRL
     FDGIALDRVS VSMTMSGAVL PVLAAFLVAA EESGVPFEQL RGTIQNDILK EFMVRNTWIH
     APQPSLRIAT DVVEWLAAHA PKFNGMSISG YHFQEAGADP VLELALTLAN ARTYVGLLRE
     RGLDVDAFCG GLSFFFGVGK PFFVEIAKLR AARLLWHDIV CELGGTSARA TAMRMHCQTS
     GWTLAAQQPL NNVARTTIEA MAAIFGGTQS LHTNGFDEAL ALPGAQASRL ARDTQLILQH
     EFGLCDVADP WAGSYLIESL TGRMVTEVRA VLAHIDAEGG ILAALESGWV QRRIHQNALR
     TQARLDAREE VVVGVNRYQE PDDNGQECLE IDGTQVRVQQ ARRLDALRSR RDDAAARHAL
     AALTEAARRG GRNLLACAID AMRCRATVGE CTRALLQVWP RHTVRASYDV ALYGTARAGN
     TEWLAACECV SALRERLGRA PRILVAKLGQ DGHDRGAKAV AAGLADAGFV VELTPLFQSA
     EAVVSAACDG DFDAIGISTL GGAHLDLLPA LLHALRQRAL EVPVFVGGIV PADHRRLLRQ
     CGVQGIFGPG TPMEIIVSTI VAALTLSRMP TA
//