ID Q0KCW2_CUPNH Unreviewed; 500 AA.
AC Q0KCW2;
DT 03-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE SubName: Full=Xanthine dehydrogenase, iron-sulfur cluster and FAD-binding subunit A {ECO:0000313|EMBL:CAJ92159.1};
DE EC=1.17.1.4 {ECO:0000313|EMBL:CAJ92159.1};
GN Name=xdhA1 {ECO:0000313|EMBL:CAJ92159.1};
GN OrderedLocusNames=H16_A1017 {ECO:0000313|EMBL:CAJ92159.1};
OS Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS / H16 / Stanier 337) (Ralstonia eutropha).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=381666 {ECO:0000313|EMBL:CAJ92159.1, ECO:0000313|Proteomes:UP000008210};
RN [1] {ECO:0000313|EMBL:CAJ92159.1, ECO:0000313|Proteomes:UP000008210}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier
RC 337 {ECO:0000313|Proteomes:UP000008210};
RX PubMed=16964242; DOI=10.1038/nbt1244;
RA Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA Eitinger T., Ewering C., Potter M., Schwartz E., Strittmatter A., Voss I.,
RA Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT eutropha H16.";
RL Nat. Biotechnol. 24:1257-1262(2006).
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DR EMBL; AM260479; CAJ92159.1; -; Genomic_DNA.
DR RefSeq; WP_011614843.1; NZ_CP039287.1.
DR AlphaFoldDB; Q0KCW2; -.
DR STRING; 381666.H16_A1017; -.
DR GeneID; 57643117; -.
DR KEGG; reh:H16_A1017; -.
DR PATRIC; fig|381666.6.peg.1396; -.
DR eggNOG; COG4630; Bacteria.
DR HOGENOM; CLU_001681_9_0_4; -.
DR OrthoDB; 9179439at2; -.
DR Proteomes; UP000008210; Chromosome 1.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:InterPro.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004854; F:xanthine dehydrogenase activity; IEA:UniProtKB-EC.
DR CDD; cd00207; fer2; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 1.10.150.120; [2Fe-2S]-binding domain; 1.
DR Gene3D; 3.30.390.50; CO dehydrogenase flavoprotein, C-terminal domain; 1.
DR Gene3D; 3.30.43.10; Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2; 1.
DR InterPro; IPR002888; 2Fe-2S-bd.
DR InterPro; IPR036884; 2Fe-2S-bd_dom_sf.
DR InterPro; IPR036010; 2Fe-2S_ferredoxin-like_sf.
DR InterPro; IPR001041; 2Fe-2S_ferredoxin-type.
DR InterPro; IPR006058; 2Fe2S_fd_BS.
DR InterPro; IPR016208; Ald_Oxase/xanthine_DH-like.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR005107; CO_DH_flav_C.
DR InterPro; IPR036683; CO_DH_flav_C_dom_sf.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016167; FAD-bd_PCMH_sub1.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR002346; Mopterin_DH_FAD-bd.
DR InterPro; IPR012175; Xanth_DH_ssu_bac.
DR InterPro; IPR014307; Xanthine_DH_ssu.
DR NCBIfam; TIGR02963; xanthine_xdhA; 1.
DR PANTHER; PTHR45444:SF3; ALDEHYDE OXIDASE_XANTHINE DEHYDROGENASE, MOLYBDOPTERIN BINDING PROTEIN; 1.
DR PANTHER; PTHR45444; XANTHINE DEHYDROGENASE; 1.
DR Pfam; PF03450; CO_deh_flav_C; 1.
DR Pfam; PF00941; FAD_binding_5; 1.
DR Pfam; PF00111; Fer2; 1.
DR Pfam; PF01799; Fer2_2; 1.
DR PIRSF; PIRSF036557; XdhA_RC; 1.
DR SMART; SM01092; CO_deh_flav_C; 1.
DR SUPFAM; SSF54292; 2Fe-2S ferredoxin-like; 1.
DR SUPFAM; SSF55447; CO dehydrogenase flavoprotein C-terminal domain-like; 1.
DR SUPFAM; SSF47741; CO dehydrogenase ISP C-domain like; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR PROSITE; PS00197; 2FE2S_FER_1; 1.
DR PROSITE; PS51085; 2FE2S_FER_2; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 4: Predicted;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022827};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:CAJ92159.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008210}.
FT DOMAIN 4..90
FT /note="2Fe-2S ferredoxin-type"
FT /evidence="ECO:0000259|PROSITE:PS51085"
FT DOMAIN 197..370
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
SQ SEQUENCE 500 AA; 53877 MW; 8673041DAB98B18B CRC64;
METQTIRFFH RGQVKEVSDA PITRTVLQYL REDARCTGTK EGCAEGDCGA CTVVVGELQD
GGDVEFKAVN ACIQFLPTLD GKALITVEDL RQADGNLHPV QEAMVECHGS QCGFCTPGFV
MSLWALYQQH TPGGEAPSRQ TICDALTGNL CRCTGYRPII DAGERMMALP APTADKLNPK
QIADTLRNLK RGETFRYRAQ GQEFFAPRSA AEFGAIKAAQ PDIRILAGST DVGLWVTKQF
RELGNLLYVG QVEDLNHIEE RDGMVEIGAA VTLEKAYAAL NAAHPELEEM WKRFASLPIR
NAGTLGGNIA NGSPIGDSMP ALIALGTEVV LQHGETRRTL PLEDLYLAYQ KTAMQPGEFV
AALRVPVAGP QHFRTYKLSK RFDEDISAVC AAFGITVQDG LVTQARIAFG GMAATPKRAA
ATEAALTGQP WDEATARAGM AALAQDYTPL SDMRATASYR SRGAANLLYR FWLETRAEAL
SAAAVNVRAI GAGATETATA
//
