ID Q0KEM4_CUPNH Unreviewed; 559 AA.
AC Q0KEM4;
DT 03-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE SubName: Full=Na+/phosphate symporter {ECO:0000313|EMBL:CAJ91547.1};
GN Name=nptA1 {ECO:0000313|EMBL:CAJ91547.1};
GN OrderedLocusNames=H16_A0397 {ECO:0000313|EMBL:CAJ91547.1};
OS Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS / H16 / Stanier 337) (Ralstonia eutropha).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=381666 {ECO:0000313|EMBL:CAJ91547.1, ECO:0000313|Proteomes:UP000008210};
RN [1] {ECO:0000313|EMBL:CAJ91547.1, ECO:0000313|Proteomes:UP000008210}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier
RC 337 {ECO:0000313|Proteomes:UP000008210};
RX PubMed=16964242; DOI=10.1038/nbt1244;
RA Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA Eitinger T., Ewering C., Potter M., Schwartz E., Strittmatter A., Voss I.,
RA Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT eutropha H16.";
RL Nat. Biotechnol. 24:1257-1262(2006).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AM260479; CAJ91547.1; -; Genomic_DNA.
DR RefSeq; WP_010814397.1; NZ_CP039287.1.
DR AlphaFoldDB; Q0KEM4; -.
DR STRING; 381666.H16_A0397; -.
DR GeneID; 57642492; -.
DR KEGG; reh:H16_A0397; -.
DR PATRIC; fig|381666.6.peg.760; -.
DR eggNOG; COG1283; Bacteria.
DR HOGENOM; CLU_025623_2_1_4; -.
DR OrthoDB; 5778511at2; -.
DR Proteomes; UP000008210; Chromosome 1.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005436; F:sodium:phosphate symporter activity; IEA:InterPro.
DR GO; GO:0044341; P:sodium-dependent phosphate transport; IEA:InterPro.
DR InterPro; IPR003841; Na/Pi_transpt.
DR InterPro; IPR004633; NaPi_cotrn-rel/YqeW-like.
DR InterPro; IPR038078; PhoU-like_sf.
DR InterPro; IPR026022; PhoU_dom.
DR NCBIfam; NF037997; Na_Pi_symport; 1.
DR NCBIfam; TIGR00704; NaPi_cotrn_rel; 1.
DR PANTHER; PTHR10010:SF39; PHOU DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR10010; SOLUTE CARRIER FAMILY 34 SODIUM PHOSPHATE , MEMBER 2-RELATED; 1.
DR Pfam; PF02690; Na_Pi_cotrans; 2.
DR Pfam; PF01895; PhoU; 1.
DR SUPFAM; SSF109755; PhoU-like; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008210};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 65..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 104..122
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 134..155
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 206..226
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 238..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..298
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 340..423
FT /note="PhoU"
FT /evidence="ECO:0000259|Pfam:PF01895"
SQ SEQUENCE 559 AA; 59639 MW; 893C32D2934E35C0 CRC64;
MGVLLHLLSG VALLVWGTNI VKVGILRVYG ANLRHVLSTS VSNRFTAFLA GLGVTGLVQS
SNATAVIVSS FVGQGLIAVA PALAIMLGAN VGTALMVQVF SLDLSWLSPL LIFVGVICHL
TWKGSRAGHV GRVLIGLGLI TLALELISIA TRPVVQAAGV KVLFASLTGD AGLDMLVGAF
LTILCYSSLA VVLFCGALAS AGVVSIHVAL ALVLGANLGS GISALLTTSG NNQPGKRVTL
GNLLSRLLGC LVALPLLGQA EELLALLDHD PQRLIVNFHL LFNVALAVLL LGATAPLARL
CEKVLPGRNT GDSQVTPRHL DTAALSTPTL ALANAAREVL RIGDRVEQML DNMLRVLRTN
DAKLADATCR IDNEVDDLYT AIKLYLTRIS LEALDERDGQ RWTEIISLTI NLEHAGDIIE
RILLDTKDKK IAHNLMFSEA GMQEIAEMHA RLVANLRLGL SVFLNGDLKS AQALMAEKAN
FRELERKYAR THLQRVAVQT AESIETSSLH LDVISELKRL NSLFCATAYP VLEQAGVLNR
SRMKEDDVPA VPAVQAAQH
//
