ID Q0KF99_CUPNH Unreviewed; 392 AA.
AC Q0KF99;
DT 03-OCT-2006, integrated into UniProtKB/TrEMBL.
DT 03-OCT-2006, sequence version 1.
DT 27-MAR-2024, entry version 103.
DE SubName: Full=Acetyl-CoA acetyltransferase {ECO:0000313|EMBL:CAJ91322.1};
DE EC=2.3.1.9 {ECO:0000313|EMBL:CAJ91322.1};
GN OrderedLocusNames=H16_A0170 {ECO:0000313|EMBL:CAJ91322.1};
OS Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS / H16 / Stanier 337) (Ralstonia eutropha).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Cupriavidus.
OX NCBI_TaxID=381666 {ECO:0000313|EMBL:CAJ91322.1, ECO:0000313|Proteomes:UP000008210};
RN [1] {ECO:0000313|EMBL:CAJ91322.1, ECO:0000313|Proteomes:UP000008210}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier
RC 337 {ECO:0000313|Proteomes:UP000008210};
RX PubMed=16964242; DOI=10.1038/nbt1244;
RA Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA Eitinger T., Ewering C., Potter M., Schwartz E., Strittmatter A., Voss I.,
RA Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT eutropha H16.";
RL Nat. Biotechnol. 24:1257-1262(2006).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AM260479; CAJ91322.1; -; Genomic_DNA.
DR RefSeq; WP_011614382.1; NZ_CP039287.1.
DR AlphaFoldDB; Q0KF99; -.
DR STRING; 381666.H16_A0170; -.
DR GeneID; 57642265; -.
DR KEGG; reh:H16_A0170; -.
DR PATRIC; fig|381666.6.peg.524; -.
DR eggNOG; COG0183; Bacteria.
DR HOGENOM; CLU_031026_0_1_4; -.
DR OrthoDB; 8558405at2; -.
DR Proteomes; UP000008210; Chromosome 1.
DR GO; GO:0003985; F:acetyl-CoA C-acetyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR18919:SF138; ACETYL-COA C-ACETYLTRANSFERASE; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:CAJ91322.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008210};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:CAJ91322.1}.
FT DOMAIN 4..261
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 270..390
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 88
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 348
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 378
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 392 AA; 41031 MW; 13C2F6061F815824 CRC64;
MEEIVIVSAA RTPMAAFQGE FASVTAPQLG AVAIRAAVER AGLKPEQVEE VVFGCVLPAG
QGQAPARQAA LGAGLPLGVG CTTVNKMCGS GMRAAMTVYD GLIAGSFDIA IAGGMESMTN
APYLVPKGRG GYRIGHGMIY DHMMLDGLED AYDKGRAMGT FGEDCAAKYG FTREQQDEFA
MESVRRAQQA TENGDFRWEI APVTVSGRGG DTVIDTDEGP RRIKLDKIPS LKPAFAKDGT
ITAASSSSIN DGASALVMMR ASTAKKLGLQ PIARMLGHTT HAQAPGWFTT APVEAISKLY
RKLDWTTDSV DLFEINEAFA VVPMAAMHDL KIPRDKVNIH GGACALGHPI GASGARIMTT
LIGALRKTGG KRGVASLCIG GGEATAVGIE IL
//
