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Database: UniProt
Entry: Q0MQI2
LinkDB: Q0MQI2
Original site: Q0MQI2 
ID   NDUS8_GORGO             Reviewed;         210 AA.
AC   Q0MQI2;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-SEP-2006, sequence version 1.
DT   16-JAN-2019, entry version 77.
DE   RecName: Full=NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial;
DE            EC=1.6.99.3;
DE            EC=7.1.1.2;
DE   AltName: Full=Complex I-23kD;
DE            Short=CI-23kD;
DE   AltName: Full=NADH-ubiquinone oxidoreductase 23 kDa subunit;
DE   Flags: Precursor;
GN   Name=NDUFS8;
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=16828987; DOI=10.1016/j.gene.2006.03.015;
RA   Mishmar D., Ruiz-Pesini E., Mondragon-Palomino M., Procaccio V.,
RA   Gaut B., Wallace D.C.;
RT   "Adaptive selection of mitochondrial complex I subunits during primate
RT   radiation.";
RL   Gene 378:11-18(2006).
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory
CC       chain NADH dehydrogenase (Complex I) that is believed to belong to
CC       the minimal assembly required for catalysis. Complex I functions
CC       in the transfer of electrons from NADH to the respiratory chain.
CC       The immediate electron acceptor for the enzyme is believed to be
CC       ubiquinone (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4
CC         H(+)(out) + NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565,
CC         Rhea:RHEA-COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389,
CC         ChEBI:CHEBI:17976, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945;
CC         EC=7.1.1.2;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=A + H(+) + NADH = AH2 + NAD(+); Xref=Rhea:RHEA:11356,
CC         ChEBI:CHEBI:13193, ChEBI:CHEBI:15378, ChEBI:CHEBI:17499,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.6.99.3;
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000250};
CC       Note=Binds 2 [4Fe-4S] clusters per subunit. {ECO:0000250};
CC   -!- SUBUNIT: Complex I is composed of 45 different subunits This is a
CC       component of the iron-sulfur (IP) fragment of the enzyme.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complex I 23 kDa subunit family.
CC       {ECO:0000305}.
DR   EMBL; DQ885652; ABH12161.1; -; mRNA.
DR   RefSeq; NP_001266636.1; NM_001279707.1.
DR   RefSeq; XP_018891215.1; XM_019035670.1.
DR   RefSeq; XP_018891216.1; XM_019035671.1.
DR   RefSeq; XP_018891217.1; XM_019035672.1.
DR   ProteinModelPortal; Q0MQI2; -.
DR   SMR; Q0MQI2; -.
DR   STRING; 9593.ENSGGOP00000004900; -.
DR   PRIDE; Q0MQI2; -.
DR   Ensembl; ENSGGOT00000005026; ENSGGOP00000004900; ENSGGOG00000005001.
DR   GeneID; 101148614; -.
DR   KEGG; ggo:101148614; -.
DR   CTD; 4728; -.
DR   GeneTree; ENSGT00390000003049; -.
DR   HOVERGEN; HBG006547; -.
DR   InParanoid; Q0MQI2; -.
DR   KO; K03941; -.
DR   OMA; EIARGMY; -.
DR   OrthoDB; 1283957at2759; -.
DR   Proteomes; UP000001519; Chromosome 11.
DR   Bgee; ENSGGOG00000005001; Expressed in 7 organ(s), highest expression level in heart.
DR   GO; GO:0005747; C:mitochondrial respiratory chain complex I; ISS:UniProtKB.
DR   GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:Ensembl.
DR   GO; GO:0009060; P:aerobic respiration; IBA:GO_Central.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IBA:GO_Central.
DR   GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; ISS:UniProtKB.
DR   GO; GO:0006979; P:response to oxidative stress; ISS:UniProtKB.
DR   HAMAP; MF_01351; NDH1_NuoI; 1.
DR   InterPro; IPR017896; 4Fe4S_Fe-S-bd.
DR   InterPro; IPR017900; 4Fe4S_Fe_S_CS.
DR   InterPro; IPR010226; NADH_quinone_OxRdtase_chainI.
DR   PANTHER; PTHR10849; PTHR10849; 1.
DR   Pfam; PF12838; Fer4_7; 1.
DR   TIGRFAMs; TIGR01971; NuoI; 1.
DR   PROSITE; PS00198; 4FE4S_FER_1; 2.
DR   PROSITE; PS51379; 4FE4S_FER_2; 2.
PE   2: Evidence at transcript level;
KW   4Fe-4S; Complete proteome; Electron transport; Iron; Iron-sulfur;
KW   Metal-binding; Mitochondrion; NAD; Oxidoreductase; Reference proteome;
KW   Repeat; Respiratory chain; Transit peptide; Translocase; Transport;
KW   Ubiquinone.
FT   TRANSIT       1     34       Mitochondrion. {ECO:0000250}.
FT   CHAIN        35    210       NADH dehydrogenase [ubiquinone] iron-
FT                                sulfur protein 8, mitochondrial.
FT                                /FTId=PRO_0000251874.
FT   DOMAIN      102    131       4Fe-4S ferredoxin-type 1.
FT   DOMAIN      141    170       4Fe-4S ferredoxin-type 2.
FT   METAL       111    111       Iron-sulfur 1 (4Fe-4S). {ECO:0000250}.
FT   METAL       114    114       Iron-sulfur 1 (4Fe-4S). {ECO:0000250}.
FT   METAL       117    117       Iron-sulfur 1 (4Fe-4S). {ECO:0000250}.
FT   METAL       121    121       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   METAL       150    150       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   METAL       153    153       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   METAL       156    156       Iron-sulfur 2 (4Fe-4S). {ECO:0000250}.
FT   METAL       160    160       Iron-sulfur 1 (4Fe-4S). {ECO:0000250}.
SQ   SEQUENCE   210 AA;  23703 MW;  663FA09AF05D1CA9 CRC64;
     MRCLTTPVLL RALAQAARAG PPGGRSLHSS AVAATYKYVN MQDPEMDMKS VTDRAARTLL
     WTELFRGLGM TLSYLFREPA TINYPFEKGP LSPRFRGEHA LRRYPSGEER CIACKLCEAI
     CPAQAITIEA EPRADGSRRT TRYDIDMTKC IYCGFCQEAC PVDAIVEGPN FEFSTETHEE
     LLYNKEKLLN NGDKWEAEIT ANIQADYLYR
//
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