ID Q0NP48_9POXV Unreviewed; 277 AA.
AC Q0NP48;
DT 19-SEP-2006, integrated into UniProtKB/TrEMBL.
DT 19-SEP-2006, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=Protein OPG166 {ECO:0000256|ARBA:ARBA00034880};
GN ORFNames=TATV_DAH68_163 {ECO:0000313|EMBL:ABD97729.1};
OS Taterapox virus.
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX NCBI_TaxID=28871 {ECO:0000313|EMBL:ABD97729.1, ECO:0000313|Proteomes:UP000139570};
RN [1] {ECO:0000313|EMBL:ABD97729.1, ECO:0000313|Proteomes:UP000139570}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Dahomey 1968 {ECO:0000313|EMBL:ABD97729.1};
RX PubMed=16873609; DOI=10.1126/science.1125134;
RA Esposito J.J., Sammons S.A., Frace A.M., Osborne J.D., Olsen-Rasmussen M.,
RA Zhang M., Govil D., Damon I.K., Kline R., Laker M., Li Y., Smith G.L.,
RA Meyer H., LeDuc J.W., Wohlhueter R.M.;
RT "Genome sequence diversity and clues to the evolution of variola (smallpox)
RT virus.";
RL Science 313:807-812(2006).
CC -!- FUNCTION: Promotes, when overexpressed, the influx of extracellular
CC Ca(2+), leading to membrane permeability and host cell necrosis.
CC {ECO:0000256|ARBA:ARBA00034660}.
CC -!- SUBCELLULAR LOCATION: Host membrane {ECO:0000256|ARBA:ARBA00004301};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004301}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the orthopoxvirus OPG166 protein family.
CC {ECO:0000256|ARBA:ARBA00034763}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQ437594; ABD97729.1; -; Genomic_DNA.
DR RefSeq; YP_717470.1; NC_008291.1.
DR GeneID; 4238706; -.
DR KEGG; vg:4238706; -.
DR Proteomes; UP000139570; Genome.
DR GO; GO:0033644; C:host cell membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0070053; F:thrombospondin receptor activity; IEA:InterPro.
DR GO; GO:0022409; P:positive regulation of cell-cell adhesion; IEA:InterPro.
DR GO; GO:0050729; P:positive regulation of inflammatory response; IEA:InterPro.
DR GO; GO:0050766; P:positive regulation of phagocytosis; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR006704; CD47.
DR InterPro; IPR013147; CD47-like_TM.
DR InterPro; IPR013270; CD47_Vset.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR10613; LEUKOCYTE SURFACE ANTIGEN CD47; 1.
DR PANTHER; PTHR10613:SF0; LEUKOCYTE SURFACE ANTIGEN CD47; 1.
DR Pfam; PF04549; CD47; 1.
DR Pfam; PF08204; V-set_CD47; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000139570};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 125..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 156..177
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 213..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 247..269
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 4..122
FT /note="CD47 immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF08204"
FT DOMAIN 126..269
FT /note="CD47-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF04549"
SQ SEQUENCE 277 AA; 31581 MW; FFD5E2FE4706E3DE CRC64;
MLRVRILLIY LCTFVVITST KTIEYTACND TIIIPCTIDN PTKYIRWKLD NHDILTYNKT
SKTTILSKWH TSAKLHSLSD NDVSLIIEYK DILPGTYTCE DNTGIKSTVK LVQRHTNWFN
DHHTMLMFIF TGITLFLLFL EIAYTSISVV FSTNLGILQV FGCIIAMIEL CGAFLFYPSM
FTLRHIIGLL MMTLPSIFLI ITKVFSFWLL CKLSCAVHII IYYQLAGYIL TVLGLGLSLK
ECVDGPLLLS GLGTIMVSEH FSLLFLVCFP STQRDYY
//
