ID JADE3_XENTR Reviewed; 817 AA.
AC Q0P4S5;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 1.
DT 27-MAR-2024, entry version 83.
DE RecName: Full=Protein Jade-3;
DE AltName: Full=Jade family PHD finger protein 3;
DE AltName: Full=PHD finger protein 16;
GN Name=jade3; Synonyms=phf16;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Scaffold subunit of some HBO1 complexes, which have a histone
CC H4 acetyltransferase activity. {ECO:0000250|UniProtKB:Q92613}.
CC -!- SUBUNIT: Component of the HBO1 complex. {ECO:0000250|UniProtKB:Q92613}.
CC -!- SIMILARITY: Belongs to the JADE family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC121924; AAI21925.1; -; mRNA.
DR RefSeq; NP_001072493.1; NM_001079025.1.
DR RefSeq; XP_017946833.1; XM_018091344.1.
DR AlphaFoldDB; Q0P4S5; -.
DR SMR; Q0P4S5; -.
DR STRING; 8364.ENSXETP00000004824; -.
DR PaxDb; 8364-ENSXETP00000022862; -.
DR GeneID; 779948; -.
DR KEGG; xtr:779948; -.
DR AGR; Xenbase:XB-GENE-978173; -.
DR CTD; 9767; -.
DR Xenbase; XB-GENE-978173; jade3.
DR eggNOG; KOG0954; Eukaryota.
DR HOGENOM; CLU_016215_1_0_1; -.
DR InParanoid; Q0P4S5; -.
DR OrthoDB; 163389at2759; -.
DR TreeFam; TF316118; -.
DR Reactome; R-XTR-3214847; HATs acetylate histones.
DR Proteomes; UP000008143; Chromosome 2.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15706; ePHD_JADE3; 1.
DR CDD; cd15681; PHD_JADE3; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 2.
DR InterPro; IPR019542; Enhancer_polycomb-like_N.
DR InterPro; IPR034732; EPHD.
DR InterPro; IPR039550; JADE3_PHD.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR13793; PHD FINGER PROTEINS; 1.
DR PANTHER; PTHR13793:SF27; PROTEIN JADE-3; 1.
DR Pfam; PF10513; EPL1; 1.
DR Pfam; PF13831; PHD_2; 1.
DR Pfam; PF13832; zf-HC5HC2H_2; 1.
DR SMART; SM00249; PHD; 2.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS51805; EPHD; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger.
FT CHAIN 1..817
FT /note="Protein Jade-3"
FT /id="PRO_0000253536"
FT ZN_FING 202..252
FT /note="PHD-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT ZN_FING 254..288
FT /note="C2HC pre-PHD-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01146"
FT ZN_FING 312..368
FT /note="PHD-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01146"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 375..396
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 665..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 719..817
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 667..689
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..742
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..759
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 775..800
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 817 AA; 92589 MW; C424B0AFC2E4A78D CRC64;
MKRLRNLSSS DSSDNESPST SFSSCFQHKG KGKCTADDGK KSAEVFRKDL ISAMKIPDSQ
HVNPEEYYQF ADTWKQEWEK GVQVPSNPEN IPQPSLRVIA EKAKEVLFTR PRKYIHCSSQ
EPAEPGYINI LELAESMCRY DLDDLDLYWL GECNLELADM GCAPVDESTM EKTLEVLERQ
CHENMNHAIE TEEGLGIEYD EDVICDVCRS PDSEEGNDMV FCDRCNICVH QACYGILKVP
EGSWLCRTCV LGLHPQCILC PKTGGAMKAT RTGTKWAHVS CALWIPEVSI ACPERMEPIT
KVSHIPPSRW ALVCSLCKLK TGACIQCSVK SCITAFHVTC AFEHSLEMKT ILDEGDEVKF
KSYCLKHSKN KHGLISEQEE PHKTHSDNRP TESERTSLRA QKLKELEEDF YTLVKVEDVA
AELGLPMLTV DFIYSFWKLK RKSNFNKPLL TPKEDEQNGL VQPKEDSIHT RMRMFMHLRQ
DLERVRNLCY MVNRREKLKL SHSKMHEEIF NLQVQLVNQE VAAGQPLSNA LENTLFYPPP
RITLKLKMPK PRTRDCRISS VKAGTMSSPD NQNSSATYHG MGGEVHRQSS EHTKLYSTYA
SEQRNNGLLG GITRFHKEFQ GTGCKPSSRF RSSGKPMSLQ AVIHGQSSNG SGKVQHEHVS
LARANGVLSS GDRTQRDSSS QTSPGQNSEI ICHIAGQSTF RKANMEHFSR SFKEATNNLV
RTTEDLRSSE KPQRRQSVKE RLWSKQPADT QTSGTPYQDN DGYCPDLELS DSEAESDENK
DHMLLRRNSR ESPNRDSCRN SRIRGKRKMT SHSSVQR
//
