ID   Q0P4U0_XENTR            Unreviewed;       238 AA.
AC   Q0P4U0; F7DZ02;
DT   19-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   19-SEP-2006, sequence version 1.
DT   27-MAR-2024, entry version 92.
DE   SubName: Full=DNA-binding death effector domain-containing protein 2 {ECO:0000313|RefSeq:NP_001072481.1};
GN   Name=dedd2 {ECO:0000313|RefSeq:NP_001072481.1,
GN   ECO:0000313|Xenbase:XB-GENE-1004127};
GN   Synonyms=MGC145883 {ECO:0000313|EMBL:AAI21907.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364 {ECO:0000313|EMBL:AAI21907.1};
RN   [1] {ECO:0000313|RefSeq:NP_001072481.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12454917; DOI=10.1002/dvdy.10174;
RA   Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA   Richardson P.;
RT   "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT   initiative.";
RL   Dev. Dyn. 225:384-391(2002).
RN   [2] {ECO:0000313|EMBL:AAI21907.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000313|EMBL:AAI21907.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|RefSeq:NP_001072481.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000256|ARBA:ARBA00004604}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC121906; AAI21907.1; -; mRNA.
DR   RefSeq; NP_001072481.1; NM_001079013.1.
DR   DNASU; 779936; -.
DR   GeneID; 779936; -.
DR   KEGG; xtr:779936; -.
DR   AGR; Xenbase:XB-GENE-1004127; -.
DR   CTD; 162989; -.
DR   Xenbase; XB-GENE-1004127; dedd2.
DR   HOGENOM; CLU_053869_2_0_1; -.
DR   OrthoDB; 3058503at2759; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006915; P:apoptotic process; IEA:InterPro.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR001875; DED_dom.
DR   InterPro; IPR038856; DEDD/DEDD2.
DR   PANTHER; PTHR15205; DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR15205:SF1; DNA-BINDING DEATH EFFECTOR DOMAIN-CONTAINING PROTEIN 2; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   PROSITE; PS50168; DED; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding {ECO:0000313|RefSeq:NP_001072481.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008143}.
FT   DOMAIN          26..148
FT                   /note="DED"
FT                   /evidence="ECO:0000259|PROSITE:PS50168"
FT   REGION          153..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        174..197
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        198..212
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        214..238
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   238 AA;  27011 MW;  78885CC07CC8CC4D CRC64;
     MPGRKRPVLC QPWEEDECLD YYGMLSLHRM FDIVGSQLTQ SDIDALSFLL HETHPFTHPL
     DPQLWTAEDE SGEAMPNSAL LSAWQRLNRD SRTLNENKLD SPDLQPKDGT ELLLKLERMG
     KCDESNFTHL LQLLRVLTRH DLLPYVSMKR PRTVSPERYT HGPSILDSDK QMDKCLNPTP
     SGTSEENWET GSNASKRKRS GTQKRGRCPK PKRNKASNTP SQNPINQSKV TCGVLSKG
//