ID Q0P5N3_BOVIN Unreviewed; 746 AA.
AC Q0P5N3; F6Q615;
DT 19-SEP-2006, integrated into UniProtKB/TrEMBL.
DT 19-SEP-2006, sequence version 1.
DT 27-MAR-2024, entry version 113.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN Name=OSBPL9 {ECO:0000313|EMBL:AAI19825.1,
GN ECO:0000313|Ensembl:ENSBTAP00000028214.6,
GN ECO:0000313|VGNC:VGNC:32467};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913 {ECO:0000313|EMBL:AAI19825.1};
RN [1] {ECO:0000313|EMBL:AAI19825.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Hereford {ECO:0000313|EMBL:AAI19825.1};
RC TISSUE=Hypothalamus {ECO:0000313|EMBL:AAI19825.1};
RA Moore S., Alexander L., Brownstein M., Guan L., Lobo S., Meng Y.,
RA Tanaguchi M., Wang Z., Yu J., Prange C., Schreiber K., Shenmen C.,
RA Wagner L., Bala M., Barbazuk S., Barber S., Babakaiff R., Beland J.,
RA Chun E., Del Rio L., Gibson S., Hanson R., Kirkpatrick R., Liu J.,
RA Matsuo C., Mayo M., Santos R.R., Stott J., Tsai M., Wong D., Siddiqui A.,
RA Holt R., Jones S.J., Marra M.A.;
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSBTAP00000028214.6, ECO:0000313|Proteomes:UP000009136}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000028214.6,
RC ECO:0000313|Proteomes:UP000009136};
RA Rosen B.D., Bickhart D.M., Koren S., Schnabel R.D., Hall R., Zimin A.,
RA Dreischer C., Schultheiss S., Schroeder S.G., Elsik C.G., Couldrey C.,
RA Liu G.E., Van Tassell C.P., Phillippy A.M., Smith T.P.L., Medrano J.F.;
RT "ARS-UCD1.2.";
RL Submitted (MAR-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSBTAP00000028214.6}
RP IDENTIFICATION.
RC STRAIN=Hereford {ECO:0000313|Ensembl:ENSBTAP00000028214.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
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DR EMBL; BC119824; AAI19825.1; -; mRNA.
DR RefSeq; NP_001068973.1; NM_001075505.2.
DR STRING; 9913.ENSBTAP00000028214; -.
DR PaxDb; 9913-ENSBTAP00000028214; -.
DR Ensembl; ENSBTAT00000028214.6; ENSBTAP00000028214.6; ENSBTAG00000021170.6.
DR GeneID; 511255; -.
DR KEGG; bta:511255; -.
DR CTD; 114883; -.
DR VEuPathDB; HostDB:ENSBTAG00000021170; -.
DR VGNC; VGNC:32467; OSBPL9.
DR eggNOG; KOG2210; Eukaryota.
DR GeneTree; ENSGT00940000154690; -.
DR HOGENOM; CLU_012334_3_0_1; -.
DR OMA; WPGSDEK; -.
DR TreeFam; TF312807; -.
DR Reactome; R-BTA-192105; Synthesis of bile acids and bile salts.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000021170; Expressed in oocyte and 111 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0032934; F:sterol binding; IBA:GO_Central.
DR GO; GO:0015248; F:sterol transporter activity; IBA:GO_Central.
DR CDD; cd13290; PH_ORP9; 1.
DR Gene3D; 1.10.287.2720; -; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF102; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 9; 1.
DR Pfam; PF01237; Oxysterol_BP; 2.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000009136};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT DOMAIN 2..99
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 225..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 691..718
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 225..245
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..299
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..360
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 361..379
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 746 AA; 84292 MW; A611DB62383B2CFC CRC64;
MASIMEGPLS KWTNVMKGWQ YRWFVLDYNA GLLSYYTSKD KMMRGSRRGC VRLRGAVIGI
DDEDDSTFTI TVDQKTFHFQ ARDADEREKW IHALEETILR HTLQLQISTT LAFFQSSGIS
PVLEFSKIIG LDSGFVPSVQ DFDKKLTEAD AYLQILIEQL KLFDDKLQNC KDDEQRKKIE
TLKETTNSMV ESIKHCIVLL QIAKSTINPV DAIYQPSPLE PVVNTMPSQT VLPPEPTQLC
KSEQRPSSLP VGPVLATLGH HQTPTPNSTG SGHSPPSSSL TSPSHVNLSP NTVPEFSYSS
SEDEFYDADE FHQSGSSPKR LIDSSGSASV LTHSSSGNSL KRPDTTESLN SSMSNGTSDA
DLFDSHDDRD DEGEAGSVEE HKSVIMHLLS QVRLGMDLTK VVLPTFILER RSLLEMYADF
FAHPDLFVSI SDQKDARDRM VQVVKWYLSA FHAGRKGSVA KKPYNPILGE IFQCHWTLPN
DTEENVELVS EGPVPWVSKN SVTFVAEQVS HHPPISAFYA ECFNKKIQFN AHIWTKSKFL
GMSIGVHNIG QGCVSCLEHD EHYILTFPNG YGRSILTVPW VELGGECNIN CSKTGYSANI
VFHTKPFYGG KKHRITAEIF SPNDKKSFCS IEGEWNGVMY AKYSTGENVV FIDTKKLPII
KKKVRKLEDQ NEYESRCLWK DVTFNLKIRD IDAATEAKHR LEERQRAEAR ERKEKEIQWE
TRLFHEDGEC WVYDEPLLKR LGAAKH
//
