ID Q0RE97_FRAAA Unreviewed; 1097 AA.
AC Q0RE97;
DT 05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2006, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE RecName: Full=HD Cas3-type domain-containing protein {ECO:0000259|PROSITE:PS51643};
GN OrderedLocusNames=FRAAL5581 {ECO:0000313|EMBL:CAJ64214.1};
OS Frankia alni (strain DSM 45986 / CECT 9034 / ACN14a).
OC Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae; Frankia.
OX NCBI_TaxID=326424 {ECO:0000313|EMBL:CAJ64214.1, ECO:0000313|Proteomes:UP000000657};
RN [1] {ECO:0000313|EMBL:CAJ64214.1, ECO:0000313|Proteomes:UP000000657}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ACN14a {ECO:0000313|Proteomes:UP000000657};
RX PubMed=17151343; DOI=10.1101/gr.5798407;
RA Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A.,
RA Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P.,
RA Goltsman E., Huang Y., Kopp O.R., Labarre L., Lapidus A., Lavire C.,
RA Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J.,
RA Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F.,
RA Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C.,
RA Benson D.R.;
RT "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT reflect host range and host plant biogeography.";
RL Genome Res. 17:7-15(2007).
CC -!- SIMILARITY: In the N-terminal section; belongs to the CRISPR-associated
CC nuclease Cas3-HD family. {ECO:0000256|ARBA:ARBA00006847}.
CC -!- SIMILARITY: In the central section; belongs to the CRISPR-associated
CC helicase Cas3 family. {ECO:0000256|ARBA:ARBA00009046}.
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DR EMBL; CT573213; CAJ64214.1; -; Genomic_DNA.
DR AlphaFoldDB; Q0RE97; -.
DR STRING; 326424.FRAAL5581; -.
DR KEGG; fal:FRAAL5581; -.
DR eggNOG; COG1203; Bacteria.
DR eggNOG; COG1688; Bacteria.
DR HOGENOM; CLU_009347_1_0_11; -.
DR Proteomes; UP000000657; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR GO; GO:0043571; P:maintenance of CRISPR repeat elements; IEA:InterPro.
DR CDD; cd09641; Cas3''_I; 1.
DR CDD; cd09693; Cas5_I; 1.
DR Gene3D; 1.10.3210.30; -; 1.
DR Gene3D; 3.30.70.2660; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006483; CRISPR-assoc_Cas3_HD.
DR InterPro; IPR038257; CRISPR-assoc_Cas3_HD_sf.
DR InterPro; IPR021124; CRISPR-assoc_prot_Cas5.
DR InterPro; IPR013422; CRISPR-assoc_prot_Cas5_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR006474; Helicase_Cas3_CRISPR-ass_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01587; cas3_core; 1.
DR NCBIfam; TIGR01596; cas3_HD; 1.
DR NCBIfam; TIGR02593; CRISPR_cas5; 1.
DR PANTHER; PTHR47959; ATP-DEPENDENT RNA HELICASE RHLE-RELATED; 1.
DR PANTHER; PTHR47959:SF16; CRISPR-ASSOCIATED NUCLEASE_HELICASE CAS3-RELATED; 1.
DR Pfam; PF09704; Cas_Cas5d; 1.
DR SMART; SM00487; DEXDc; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51643; HD_CAS3; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000000657}.
FT DOMAIN 267..494
FT /note="HD Cas3-type"
FT /evidence="ECO:0000259|PROSITE:PS51643"
FT REGION 581..616
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..606
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1097 AA; 118698 MW; 3234C78403F9A331 CRC64;
MSAAAGWRQP SEAVEALRVE LAVPIASFRD PMFPGVSRCL PVPPPSTVRG MLAAATGRPS
ETVPLGLAAS ATANGVDLET YHPIAADGSN PASGGRVAPG KGGMTIRERP FLAGVRVTLW
IPGAAGRRIE AALRRPVWGL RLGRSQDLVH LVGAPRWTVL HPAERAMVGH AVAPPDGHAA
PQAVSLRLAV AVSADRLSTD YRSFLWCADA AGTHAVHGAY LDGLDGQAVW LLDGDADGDA
DGDAAAGSAA DASELDTILA KSADRSVDDE PERLTAHAQA VRDAARSIAA RIGPAGPIAD
EPRFWAWVEQ AALLHDAGKV AEGFQRQIHP GGRPWSERHE VLSLAYVDLF HPEPPAEAET
ATDAGAATDR LMTATGVLFH HRSLTTSGLG GKEPLVSRYF EDADWARYFW RGTPDDIRDG
KPRLQIPRRR HAELLAWFAD RLDLAPDPAE GRRLWERARA LFLATRDHWI DPVTDREGLL
AVLLQGAVTL ADHAGSAHVP LQTHMPLPRR YLDRIPAPYD HQRAAAAVEG HLILLAPTGS
GKTEAGLAWA SARLDGMPDQ PRLVWMLPYR ASIDAAADRF RDDLVPPPNH NLPPVHGEPP
PGPGEPDRPD TPDRPDIGIL HATAARTLLE RAVAEDCAPP AEAALKARAR VGAMRLFAQR
VRVATPHQLL RAAIAGPRYS SVLLEQANCL MVLDELHAYD PVTFGRICAA MRLWSQLGSQ
VAVLSATLSM PMIELVQDSL GGTVEVVHAA PGTAPDRHRL VLADAPITAP ASLDAVRRWL
AEGRSVLVVA NTVRTAQQLY ADLAPAARAA APDVDGRDAD ADAAILLHSR FRARDRAAIE
RRILARHPER QPGDPARRSG GLVVSTQALE VSLCLDFDRG ASELAPIEAV AQRAGRVNRR
GRHPDGPVEF RVHPVEKHLP YEEEALAAAW SALRSTADTD PTISEQTVTA WLDHVYATDW
GRRWAATARQ HRDAFSTSFL TFQRPFDDRS EFARGLAEQF DTVHVLHRDD LPEYRELADR
DRGGPLLAEG LLIPIGFHQY LRLAKAGRAE VHRGLRLATV DAPYSAETGL DLSVLDDENA
RFDDRSGHRP ADLDTIL
//
