ID Q0RLF6_FRAAA Unreviewed; 407 AA.
AC Q0RLF6;
DT 05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2006, sequence version 1.
DT 27-MAR-2024, entry version 100.
DE SubName: Full=Heme biosynthesis protein {ECO:0000313|EMBL:CAJ61648.1};
GN OrderedLocusNames=FRAAL3004 {ECO:0000313|EMBL:CAJ61648.1};
OS Frankia alni (strain DSM 45986 / CECT 9034 / ACN14a).
OC Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae; Frankia.
OX NCBI_TaxID=326424 {ECO:0000313|EMBL:CAJ61648.1, ECO:0000313|Proteomes:UP000000657};
RN [1] {ECO:0000313|EMBL:CAJ61648.1, ECO:0000313|Proteomes:UP000000657}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ACN14a {ECO:0000313|Proteomes:UP000000657};
RX PubMed=17151343; DOI=10.1101/gr.5798407;
RA Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A.,
RA Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P.,
RA Goltsman E., Huang Y., Kopp O.R., Labarre L., Lapidus A., Lavire C.,
RA Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J.,
RA Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F.,
RA Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C.,
RA Benson D.R.;
RT "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT reflect host range and host plant biogeography.";
RL Genome Res. 17:7-15(2007).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CT573213; CAJ61648.1; -; Genomic_DNA.
DR AlphaFoldDB; Q0RLF6; -.
DR STRING; 326424.FRAAL3004; -.
DR KEGG; fal:FRAAL3004; -.
DR eggNOG; COG0535; Bacteria.
DR HOGENOM; CLU_009273_4_3_11; -.
DR OrthoDB; 9782387at2; -.
DR Proteomes; UP000000657; Chromosome.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR InterPro; IPR023885; 4Fe4S-binding_SPASM_dom.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR017200; PqqE-like.
DR InterPro; IPR007197; rSAM.
DR NCBIfam; TIGR04085; rSAM_more_4Fe4S; 1.
DR PANTHER; PTHR11228:SF7; PQQA PEPTIDE CYCLASE; 1.
DR PANTHER; PTHR11228; RADICAL SAM DOMAIN PROTEIN; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR PIRSF; PIRSF037420; PQQ_syn_pqqE; 1.
DR SFLD; SFLDG01386; main_SPASM_domain-containing; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000000657};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691}.
FT DOMAIN 3..219
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 407 AA; 44315 MW; 493132946E57A566 CRC64;
MRGRRRTYAV WELTLACNLA CGHCGSRAGA RRPAELSTGQ ALDVVAQLDA VGVDEVTLIG
GEAFLRRDWL TIAAEITRRG MGCTVTTGGY RLSAAMARGL RAAGVTQCSV SVDGMTATHD
RLRGRAGSWQ SCFLTMERLR SAGVEATCNT QLNRLTTPEL PELYRRLRSA GAVAWQWQLT
VPMGNAADHA DLLLQPVELL EVFPVLARIA RRARQDGVRI HAGNNVGYYG PYERLLRSPE
SAAFWTGCQA GLSTLGIESD GTIKGCPSLP TRDYAGGNIR DRSLTDLLRD APELGINLTA
GTPAATGKLW GFCRGCTFAE VCRGGCTWTA HTVFGRPGNN PYCHHRALAH QRAGRRERLV
QTAVPPGEPF DHGLFALVEE DLDAHWPATE RPRLTAADIR WPADWVD
//
