ID Q0RU01_FRAAA Unreviewed; 725 AA.
AC Q0RU01;
DT 05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT 05-SEP-2006, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN OrderedLocusNames=FRAAL0267 {ECO:0000313|EMBL:CAJ58944.1};
OS Frankia alni (strain DSM 45986 / CECT 9034 / ACN14a).
OC Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae; Frankia.
OX NCBI_TaxID=326424 {ECO:0000313|EMBL:CAJ58944.1, ECO:0000313|Proteomes:UP000000657};
RN [1] {ECO:0000313|EMBL:CAJ58944.1, ECO:0000313|Proteomes:UP000000657}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ACN14a {ECO:0000313|Proteomes:UP000000657};
RX PubMed=17151343; DOI=10.1101/gr.5798407;
RA Normand P., Lapierre P., Tisa L.S., Gogarten J.P., Alloisio N.,
RA Bagnarol E., Bassi C.A., Berry A.M., Bickhart D.M., Choisne N., Couloux A.,
RA Cournoyer B., Cruveiller S., Daubin V., Demange N., Francino M.P.,
RA Goltsman E., Huang Y., Kopp O.R., Labarre L., Lapidus A., Lavire C.,
RA Marechal J., Martinez M., Mastronunzio J.E., Mullin B.C., Niemann J.,
RA Pujic P., Rawnsley T., Rouy Z., Schenowitz C., Sellstedt A., Tavares F.,
RA Tomkins J.P., Vallenet D., Valverde C., Wall L.G., Wang Y., Medigue C.,
RA Benson D.R.;
RT "Genome characteristics of facultatively symbiotic Frankia sp. strains
RT reflect host range and host plant biogeography.";
RL Genome Res. 17:7-15(2007).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR EMBL; CT573213; CAJ58944.1; -; Genomic_DNA.
DR AlphaFoldDB; Q0RU01; -.
DR STRING; 326424.FRAAL0267; -.
DR KEGG; fal:FRAAL0267; -.
DR eggNOG; COG0210; Bacteria.
DR HOGENOM; CLU_023846_0_0_11; -.
DR Proteomes; UP000000657; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF68; DNA HELICASE; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000000657}.
FT DOMAIN 253..522
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT BINDING 274..281
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 725 AA; 80859 MW; DCB0110F9C5C1D76 CRC64;
MGFEQWTRGG DVARLGIDKE FLLGFAALEK QVQNRVLDVF AKFEAATHAG LHLEKIGNVR
DDRFRTIRID RFWRGVVLAP DSGDTYTLLR VLPHDDAYAW AQRRRVSVNA ATGRNEIRDV
VAIDATLPEL TRRAEQAPSR LFADVADKDL RRLGIDEQTL AFARVLTDVR QLEMARGFLP
PNQWDALFGL AAGMTPEEVW AEIGAASEAD RASFDADDVV AAVERSADRV VLVDGPEELL
EVFRHPFALW RVYLHPTQRR IAQARFRGPA RVTGGPGTGK TVVALHRARD LASQGVGRVL
LTTFTSTMCD SLAADLDLLV HDPLERERIT VATVNKIAYD VFRAWQPQPT ILTDAEERAV
WRTATRGLGL PFSESFLSEE WRQVILAQEI LTEAGYQKAR RAGRGRPLGP RQRAQVWAAW
RQFDRELRAS GRWTHEMICV EAARLLERAP HRPYRHVVID EAQDLSPVQW RFLRTAVKPG
ADDFFLAGDA HQRIYHNRVS LRELGIQVVG RSARLTVNYR TTAEILAWSL GMLRGEPIDD
LDGGLDSVAG YRSELHGPVP RLQGFATWND EIREAAEQVR AWIRAGVAPD EIGVAVRSNK
FAESLLPALH RLGVPARLLA RLPEQQPAPI ERAGGPAVAV GTMHRMKGLE FRCLTVLGVG
ERQVPAPGAV TPAGEDEIAH AQDVQRERCL LFVACTRARE ELYISWHGAQ SPFLAQLGPA
AVRST
//
