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Database: UniProt
Entry: Q0SE34_RHOJR
LinkDB: Q0SE34_RHOJR
Original site: Q0SE34_RHOJR 
ID   Q0SE34_RHOJR            Unreviewed;      4903 AA.
AC   Q0SE34;
DT   05-SEP-2006, integrated into UniProtKB/TrEMBL.
DT   05-SEP-2006, sequence version 1.
DT   24-JAN-2024, entry version 122.
DE   SubName: Full=Non-ribosomal peptide synthetase {ECO:0000313|EMBL:ABG94202.1};
DE            EC=5.1.1.12 {ECO:0000313|EMBL:ABG94202.1};
DE            EC=6.2.1.26 {ECO:0000313|EMBL:ABG94202.1};
GN   OrderedLocusNames=RHA1_ro02397 {ECO:0000313|EMBL:ABG94202.1};
OS   Rhodococcus jostii (strain RHA1).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC   Rhodococcus.
OX   NCBI_TaxID=101510 {ECO:0000313|EMBL:ABG94202.1, ECO:0000313|Proteomes:UP000008710};
RN   [1] {ECO:0000313|Proteomes:UP000008710}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RHA1 {ECO:0000313|Proteomes:UP000008710};
RX   PubMed=17030794; DOI=10.1073/pnas.0607048103;
RA   McLeod M.P., Warren R.L., Hsiao W.W.L., Araki N., Myhre M., Fernandes C.,
RA   Miyazawa D., Wong W., Lillquist A.L., Wang D., Dosanjh M., Hara H.,
RA   Petrescu A., Morin R.D., Yang G., Stott J.M., Schein J.E., Shin H.,
RA   Smailus D., Siddiqui A.S., Marra M.A., Jones S.J.M., Holt R.,
RA   Brinkman F.S.L., Miyauchi K., Fukuda M., Davies J.E., Mohn W.W.,
RA   Eltis L.D.;
RT   "The complete genome of Rhodococcus sp. RHA1 provides insights into a
RT   catabolic powerhouse.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15582-15587(2006).
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
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DR   EMBL; CP000431; ABG94202.1; -; Genomic_DNA.
DR   RefSeq; WP_011595136.1; NC_008268.1.
DR   KEGG; rha:RHA1_ro02397; -.
DR   PATRIC; fig|101510.16.peg.2428; -.
DR   eggNOG; COG1020; Bacteria.
DR   HOGENOM; CLU_000022_0_8_11; -.
DR   OMA; CTGVQKS; -.
DR   OrthoDB; 5475787at2; -.
DR   UniPathway; UPA00011; -.
DR   Proteomes; UP000008710; Chromosome.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0043604; P:amide biosynthetic process; IEA:UniProt.
DR   GO; GO:0019752; P:carboxylic acid metabolic process; IEA:UniProt.
DR   GO; GO:0008610; P:lipid biosynthetic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR   CDD; cd05930; A_NRPS; 1.
DR   CDD; cd17646; A_NRPS_AB3403-like; 1.
DR   CDD; cd19540; LCL_NRPS-like; 2.
DR   Gene3D; 3.30.300.30; -; 4.
DR   Gene3D; 3.40.50.980; -; 8.
DR   Gene3D; 1.10.1200.10; ACP-like; 3.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 5.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 5.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR025110; AMP-bd_C.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR010060; NRPS_synth.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR020802; PKS_thioesterase.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR001031; Thioesterase.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 4.
DR   NCBIfam; TIGR01720; NRPS-para261; 1.
DR   PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR   Pfam; PF00501; AMP-binding; 4.
DR   Pfam; PF13193; AMP-binding_C; 4.
DR   Pfam; PF00668; Condensation; 5.
DR   Pfam; PF00550; PP-binding; 4.
DR   Pfam; PF00975; Thioesterase; 1.
DR   SMART; SM00823; PKS_PP; 4.
DR   SMART; SM00824; PKS_TE; 1.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 4.
DR   SUPFAM; SSF47336; ACP-like; 4.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 10.
DR   PROSITE; PS00455; AMP_BINDING; 4.
DR   PROSITE; PS50075; CARRIER; 4.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 4.
PE   4: Predicted;
KW   Isomerase {ECO:0000313|EMBL:ABG94202.1};
KW   Ligase {ECO:0000313|EMBL:ABG94202.1};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008710}.
FT   DOMAIN          953..1027
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2466..2541
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          3508..3583
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          4566..4641
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          935..957
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          4883..4903
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        939..957
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   4903 AA;  526512 MW;  C94F5AE59491CD48 CRC64;
     MSSPTSVGPG DSSARAFPLS PAQTGMWLAQ HVDPTVPVSV AQYVDIHGDL DRGVLTDACV
     RAAAEFESFF LKVSDIDGQP LQWVDPSLDA SVGYLDFRDK PDPEASAHAW MRTETADPID
     IQRDRLTVSF LLHVGHDHYF WYSRAHHLAM DGFGSVTMLY RIAALYTAAV HGLPPPASSP
     VGLRRIHELE TDYRTSARRE SDRDYWTETM RGVTHASTLA RGSAPATAGS RNVGGTLTTE
     AVDQLEKCAA AHGVNPATLT VCAVAGYLAR MTGADDVTLS LPVSARTTAA LRRSGGMVSN
     VVPLRITSAG TGTVGDLVSR TRLVMSGALR HQRYRHEDIR ADLGSAVSGS RLFGPAVNIM
     LFPEELDLGS LRSQLHVLSS GPIEDLLVNL YRYGPRGRVH LDFKANPRLY SQDELEGHHT
     RFLRYFRHFL DADAAHPIGE LPVLTENETA ALVPFPGPPD SVPVTLADVF RAAATQHPDA
     TAVVTAGSEI TYRELDGRSD RIAATLARLG VGSGDVVAVA LPRSSGHVCA VWAVAKTGAA
     FLPVDPTYPV SRVRHMLGDS HAAVGLTSAE YTNTLPDSTE WLLLDESGGS NVHDFPTPTI
     RLDDAAYLVY TSGSTGVPKG VVVTHRGIAN LVSAQRTRLD LDSAARVLHV ASPSFDASVF
     EMLMAFGSGA ALVIAPPAVF GGSPLARLMT TERVTHAVIT PSVLASMDPG EVGGLRTLVV
     AGEKCPPELV SRWASRCRMI DAYGPAETTV MATVSEPLAE PGPVTVGRPI RGARAVVLDH
     RLRPVPVGVV GELYVAGTAL ARGYHRNARQ TSERFVADPY GPPGTRMYRT GDTVRWTYDH
     ELEYLGRSDE QVNLRGLRVE PGEIDATLLR YPAVRFAVTV IRSRGAGDQL VSYVVGADTV
     TEQDLLSFLS TELPPHLVPA AVVVLPDIPL TPSGKLDRTA LPEHSRRSRS RTAPRNERER
     TLHALYADIL GTSAFGVDES FFALGGDSIM AIQLASRARS AGISFTPRDV FENRTISRLG
     QVAGGACDRP VLAELPGGGV GDLPLTPAAR FLLDRAGVID RYAQAVVVEL PRAIDPDTLD
     SVIGAVVERH DALRARLVCG ADGTAFLTVR PAGAPLPVGT ILRVPLPAHA DPAQRTRDEH
     EAAVCRLNPA AGVMVQCVWL DPGPDDTTRR GRLLLVAHHL VIDGVSWRIL IGDLAAAWTQ
     VKAGVPPTLA SIGTSLRRWS HGLVEEAQRP GRRSELSFWR EMTAYEDSPL GSRPLDAGRD
     VNSTVDRVHT EVSADVTHSL LTDLPAAFRC EVNDALLTAL TLALAQWQRR RGRPATAPVI
     RLEGHGREEA VLPGADLSRT VGWFTSIFPI RLDLGDVDLD DAFAGGHAAS TAIKLVKEQL
     RAVPDKGIGY GLLRYPGGDP GQVAFNYLGR LDTAETEHDW RPVRDDAAVF SSAEPSMPVT
     ALIDITAFTA RGVLDATFAY PTGAIASEDV RALTDLWEQA LTALAAVPRS PHAGGLTPSD
     LPLVAVDRND IDEWERDRPG LLDVWPVTPL QSGLLFHAAL TGTDADPYAM QVILSLSGHL
     DQDRLRRACS AVLAGHANLR TAFVRDSRGV PVQLVLDDVP LRWRQIDLTD VTEDPEDILR
     DDRTTRFDMS APPLVRFTLL SRGPTRADLA ITAHHIVLDG WSMPLLVREL FTAYPRDDVR
     TESPDSSPYR DYLEWLTAKD TEASARAWVA ALDGITEPAV AAEPTPTTSE AVLELSEEGT
     RKLTARATEV GVTLSTIVQA AWGIVLGQAT ARDDVVIGAT VSGRPADVAG VESAVGLFVN
     TVPVRIPLDP DIDTATLVTR LQADHVRLLE HHHLGLADIQ HAVGVAPLFD TLVAFESYPV
     DRTALPEPVD GLTLDGVRAH DASHYAVTLA VTVSRTVRLT AKCRSHRYDE KALLARVGRV
     LECIGRDPHV VLGGLDLLGD QERERVLRTW NATDAPVPSQ TLVDLFDAQV ERSPEAVAVI
     FGPDRLTYAE FDARVNRLAR YLVAKGIVPE TVVGVAVSRS IQLLVALHAV LKAGGAYLPM
     DPEHPLGRTA LVIDSAAPAL VLTSGSHNRA VPHGVAVVDL DLLDLTGYDA RSITNSERRA
     PLHPANAAYV IYTSGSTGRP KGVTVTHEMM VNQFRWAQTL TPLDGSDAVL HKTPLTFDIS
     AWELLWPLHT GARVVIAAPD GHRDPRYLAR MVAQESITTL HVVPSMLDAF LEQCGPRELA
     PLRRVYSAGE PLSAATASRF EERSAAALYN WYGPCEAAAA TSESLDGNEF GTSVAIGRPI
     HNIRTYVLDS RLRPVPVGTR GELYLAGAYL ARGYAGRPDL TAERFVADPF GETGGRMYRT
     GDVVRWNESG RLEYLGRTDF QIKLRGQRVE PGEIESALTS DPAVTHAAVT VHRDAEAGDR
     LIAYVVAADG VPPDERRIVD RLAGLLPAYM IPSAVVPLPA LPLTTSGKLD RAALPEPAPV
     ASAFDPPATP TEDVVAFVFA EVTGTGRVGR HDNFFAAGGN SLTAAQAVAR VGAALGTSVD
     IRALFDHPTV AELSEYLANG SHRTGRAPLV PRAPTAHVPL SLAQQRLWFL NRLDGRSATD
     SIPVALRLTG TLDESALCAA VGDVIERHEP LRTVYPEHDG IPCQQVLPAS AVPPCTVRTT
     TDPVGRVRDL LSTGFDLATE PPFRTELLAV SADEWVLALV VHHISADGFS LGPLARDVMA
     AYRARAQGNS PVWTPLPVRY ADYALWQREL QDGQRGLAYW TQTLSGLPEL LPLPFVRGRP
     SVATHRGANV EFILDAEIHR RIRALARAHD ATPFMVVHTA LAVLAARLGD TSDIVVGTPI
     AGRGPRALDD LVGMFVNTLV LRTDVPLHTT FADTLGRVRD VDLAAYAHAD VSFEEVVEAV
     APARSRGRNP LFQLALAYHN TAPVVIDLPE VSATIVEIET HTAKFDLQLT VTESVDDADA
     PAPLSCVFTY ATDLFDDATV SGFADRFQRI LRAALAQPSV VIGDIDVRDL AEQQARHHGP
     PSVPQRTLPD LMSAAARQNP GGPALTADGR SMAYRELDAE SNRLARALMR RGVGPEAFVA
     LGVPRSVLSV VSVWAVAKTG AAFVPVDPHY PAARVRYLMD DSGAVLGLTT AADREALPDG
     TDWLLLDDPD FRTECRGYSS APVTDADRAR PLDARHPAYV IYTSGSTGNP KGVVVTHTGL
     ADFTAEQRER YSVTASSRTL HASSPSFDGS VLEILLALGA GACMVLAPPA VQADDQLTDL
     LARERVSHVF TTPTVLATVD PRGLHDLRVV VAGGEPCPPE LVAVWAAQEQ MYNGYGPTET
     TVMTSISDPM AAGGPVTIGR PIRGAAVLLL DSRLHPVPTG VAGELYISGP GVARGYHRRP
     ALTAARFVAS PFGASGERMY RTGDVGRWRR DGSIEYLHRN DSQIELRGVR IELGEIDATL
     LAHPTVRFAA TDVRELRDGV DALVSYVVPA RNETVDPDQL IRFAATRLPM PLVPAIVVVV
     DAVPLTVNGK LDRSALPDPV PAATEFEAPH TPAERVVATV FAEVLGLDLV GREANFFALG
     GSSLSATRAA SRIGAALETT VPVRAVFDTP TVSALAASVT EQTDGATHVA LTVRPRPARV
     PLSPAQQRLW FLARLAPGSP EYNIPMALRL TGALDVAALT AAVADVISRH EPLRTVYPDK
     DGVAYQQLIP VSRAAPILRP IPVSRGDVAA RVATFASKGF ALGAEPPFRA RLFAPAPDEW
     VLAIMVHHIS TDGFSVPVLV RDVMTAYEAR VSGEAPRWAD LPVQYTDYTL WQHELLGDRD
     DPQSVAAQQL SYWKDTLSGA PEQLSLPADR PHPAIASHRG GTVEFAIDDA LYRAVEHTAT
     ALAVTPFMIV HAAFAVLLAR LSGSTDIVIG TPVAGRGDQA LDDLVGMFVN NLVLRTEVIP
     AESFAELLGR VREVDLDAFA HSTVPFETVV EVLDPARSRA RNPLFQVALA FQNLDHTPLT
     LPGLRVSAMT PPTRSARFDL QLTVTADPDP STERTRHAAV FTYATDLFDH HTVADIGERF
     IRMLSEAVAQ PDTAVGDLAL LDPDPDVPTA TPSSGETLVD LFERQVAAAP DAIAVVSGDR
     TLTYRELDEQ VNRLARHLIG AGVGPESMVG LAIRRSVDLL VGMYAVATAG GAYVPIDPDQ
     PGQRNAQVIR SSATRVVLTT ERDRFDLSDV LPAETRLVVI DRVDLSGVDP SPISDLDRIA
     PLLAQHPAYV IHTSGSTGTP KGVVVTHAAV VSFLSWRQDT DPLGADDTVM LKLQYTFDAS
     VREFWWPLIA GARMVIARPD GHRDPRHLAE LIGRHRVTAG YFLPLMLAEI LAIPEADLTS
     LRQVSCGGEV LPPGTAHSVH ARCPDAVLYN EYGPTETAVA VTRTVVGTEA ATVPIGVPQN
     GVGVLVLDSR LHPVPIGVPG ELYLAGAQLA RGYLGQPGAT AARFPANPWG PPGQRMYRTG
     DVVSRRRDGT IDYLGRRDLQ VKIRGQRVEL EEIETALRRH AAVAQSAAAV YESAGTGARL
     VGYVVPHPDM VVDTRAVSAE LAQRLPRYMV PNQIVVLGAL PSTPHGKLDR RALPDPGVPR
     AQRFRPPTTR TEKLVTAVFA DVLGTGLVGL DDNFFELGGN SLSATRAASR LHTSTRVEVR
     LDWFFADATA ESIAARISSS FAAASAASAG LGVLLPLHPD GGREPLFCIH PAIGLAWCYA
     GLGAHLGPDR PVWGVQSPAV TVPGERFASI TQRAHRYVEE IRRVQPRGPY HLLGYSVGGV
     IAHAMAVELR SRGEEVGVLA MIDSYAAAER DTPAPTLPEL LTEFGGGASE HLGPEQLTRL
     YEDYVDVVDA AADFVPGHFD GDLVFFGAAG NGSQPAPASE TWRPWIDGDV IAHTVDRPHT
     RMTDPEALAV IGPILAEYLA GASATDGTEN PPPTQRETAQ RHE
//
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